Dr Jose M. Jimenez-Guardeño Research fellows Research Fellow Contact details jose.jimenez@kcl.ac.uk +44 (0) 20 7188 5398
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2: Quantum-inspired identification of SARS-CoV-2 antivirals Jimenez Guardeno, J., Ortega Prieto, A., Menendez Moreno, B., Maguire, T., Richardson, A., Diaz-Hernandez, J. I., Diez Perez, J., Zuckerman, M., Mercadal Playa, A., Cordero Deline, C., Malim, M. & Martinez Nunez, R., 18 Jul 2022, In: PLoS Computational Biology. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pcbi.1010330 TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction Khan, H., Winstone, H., Jimenez Guardeno, J., Graham, C., Doores, K., Goujon, C., Matthews, D., Davidson, A., Rihn, S., Palmarini, M., Neil, S. & Malim, M., 9 Nov 2021, (Accepted/In press) In: Plos pathogens. Research output: Contribution to journal › Article › peer-review Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation Lista, M. J., Matos, P. M., Maguire, T. J. A., Poulton, K., Ortiz-Zapater, E., Page, R., Sertkaya, H., Ortega-Prieto, A. M., Scourfield, E., O'Byrne, A. M., Bouton, C., Dickenson, R. E., Ficarelli, M., Jimenez-Guardeño, J. M., Howard, M., Betancor, G., Galao, R. P., Pickering, S., Signell, A. W., Wilson, H. & 17 others, Cliff, P., Kia Ik, M. T., Patel, A., MacMahon, E., Cunningham, E., Doores, K., Agromayor, M., Martin-Serrano, J., Perucha, E., Mischo, H. E., Shankar-Hari, M., Batra, R., Edgeworth, J., Zuckerman, M., Malim, M. H., Neil, S. & Martinez-Nunez, R. T., 15 Sep 2021, In: PLoS ONE. 16, 9 September, e0256813. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0256813 An overview of vaccines against sars-cov-2 in the covid-19 pandemic era Pascual-Iglesias, A., Canton, J., Ortega-Prieto, A. M., Jimenez-Guardeño, J. M. & Regla-Nava, J. A., Aug 2021, In: Pathogens. 10, 8, 1030. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/pathogens10081030 MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation Betancor Quintana, G. J., Jimenez Guardeno, J., Lynham, S., Antrobus, R., Khan, H., Sobala, A., Dicks, M. & Malim, M., Aug 2021, In: Nature Microbiology. 6, p. 1031–1042 Research output: Contribution to journal › Article › peer-review Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia Braga, L., Ali, H., Secco, I., Chiavacci, E., Neves, G., Goldhill, D., Penn, R., Jimenez-Guardeño, J. M., Ortega-Prieto, A. M., Bussani, R., Cannatà, A., Rizzari, G., Collesi, C., Schneider, E., Arosio, D., Shah, A. M., Barclay, W. S., Malim, M. H., Burrone, J. & Giacca, M., 3 Jun 2021, In: Nature. 594, 7861, p. 88-93 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41586-021-03491-6 Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Graham, C., Seow, J., Huettner, I., Khan, H., Kouphou, N., Acors, S., Winstone, H., Pickering, S., Ribeiro Galao, R. P., Dupont, L., Lista Brotos, M., Jimenez Guardeno, J., Laing, A., Wu, Y., Joseph, M., Muir, L., van Gils, M. J., Ng, W., Duyvesteyn, H., Zhao, Y. & 9 others, Bowden, T. A., Shankar-Hari, M., Rosa, A., Cherepanov, P., McCoy, L. E., Hayday, A., Neil, S., Malim, M. & Doores, K., 29 Mar 2021, (Accepted/In press) In: Immunity. Research output: Contribution to journal › Article › peer-review Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O’Byrne, A., Kouphou, N., Galao, R. P., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Huettner, I., Jimenez-Guardeño, J. M., Lista, M. J., Temperton, N., Snell, L. B. & 22 others, Bisnauthsing, K., Moore, A., Green, A., Martinez, L., Stokes, B., Honey, J., Izquierdo-Barras, A., Arbane, G., Patel, A., Tan, M. K. I., O’Connell, L., O’Hara, G., MacMahon, E., Douthwaite, S., Nebbia, G., Batra, R., Martinez-Nunez, R., Shankar-Hari, M., Edgeworth, J. D., Neil, S. J. D., Malim, M. H. & Doores, K. J., 1 Dec 2020, In: Nature Microbiology. 5, 12, p. 1598-1607 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41564-020-00813-8 The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction Betancor, G., Dicks, M. D. J., Jimenez Guardeno, J. M., Ali, N. H., Apolonia, L. & Malim, M. H., 12 Nov 2019, In: Cell Reports. 29, 7, p. 1923-1933.e3 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.celrep.2019.10.009 Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice Skelton, J. K., Ortega-Prieto, A. M., Kaye, S., Jimenez-Guardeño, J. M., Turner, J., Malim, M. H., Towers, G. J., Dorner, M. & Kirchhoff, F., 1 Jun 2019, In: Journal of Virology. 93, 11, e0212318. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1128/JVI.02123-18 View all publications