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King’s People

Dr Jose M. Jimenez-Guardeño

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Research Fellow

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Biography

Jose gained his PhD in the laboratory of Professor Luis Enjuanes at the Spanish National Biotechnology Centre (CNB-CSIC) in 2015. His PhD work focused on the study of the virus-host interactions contributing to SARS-CoV virulence. He joined the Malim lab in September 2015 and was awarded an EMBO Long-Term Fellowship in 2016. His current research focused on understanding the mechanisms leading to the interferon-induced block to HIV-1 infection.

Latest publications

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O'Byrne, A., Kouphou, N., Galao, R. P., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Huettner, I., Jimenez-Guardeño, J. M., Lista, M. J., Temperton, N., Snell, L. B. & 22 others, Bisnauthsing, K., Moore, A., Green, A., Martinez, L., Stokes, B., Honey, J., Izquierdo-Barras, A., Arbane, G., Patel, A., Tan, M. K. I., O'Connell, L., O'Hara, G., MacMahon, E., Douthwaite, S., Nebbia, G., Batra, R., Martinez-Nunez, R., Shankar-Hari, M., Edgeworth, J. D., Neil, S. J. D., Malim, M. H. & Doores, K. J., Dec 2020, In : Nature Microbiology. 5, 12, p. 1598-1607 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41564-020-00813-8
The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction
Betancor, G., Dicks, M. D. J., Jimenez Guardeno, J. M., Ali, N. H., Apolonia, L. & Malim, M. H., 12 Nov 2019, In : Cell Reports. 29, 7, p. 1923-1933.e3 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.celrep.2019.10.009
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice
Skelton, J. K., Ortega-Prieto, A. M., Kaye, S., Jimenez-Guardeño, J. M., Turner, J., Malim, M. H., Towers, G. J., Dorner, M. & Kirchhoff, F., 1 Jun 2019, In : Journal of Virology. 93, 11, e0212318. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1128/JVI.02123-18
Immunoproteasome activation enables human TRIM5ï¡ restriction of HIV-1
Jimenez Guardeno, J. M., Apolonia, L. F. S., Betancor Quintana, G. J. & Malim, M. H., 1 Jun 2019, In : Nature Microbiology. 4, 6, p. 933-940 8 p. Research output: Contribution to journal - Letter. DOIs: https://doi.org/10.1038/s41564-019-0402-0
Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction
Dicks, M. D. J., Betancor, G., Jimenez-Guardeno, J. M., Pessel-Vivares, L., Apolonia, L., Goujon, C. & Malim, M. H., 15 Oct 2018, (Accepted/In press) In : PLoS Pathogens. 14, 11, e1007408. Research output: Contribution to journal - Article

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