Dr Joseph Bateman BSc, PhD, PGCAP

Biography

My lab aims to understand basic processes in neuronal function and development by identifying the key pathways and genes involved to provide novel insight into neurological disease.Our work will contribute in the long term to improved quality of life by providing new knowledge about nervous system function and development that can be used to combat neuropathological disease. Our two main areas of interest are:

• Mitochondrial dysfunction in the nervous system and its role in neurodegenerative disease
• Regulation of neurogenesis by mTOR signalling and its role in epilepsy

Please see my Research Staff Profile for more detail.

Key Publications:

• Hunt et al., 2019. Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate. Journal of Cell Biology.
• Duncan et al., 2018. Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. PLOS Genetics.
• Gatt et al., 2016. Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency. Movement Disorders.
• Cagin et al., 2015. Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci USA
• Avet-Rochex et al., 2014. Unkempt is Negatively Regulated by mTOR and Uncouples Neuronal Differentiation from Growth Control. PLoS Genetics.

View all publications

Key Collaborators:

• Professor Navdeep Chandel, Northwestern University
• Professor Jernej Murn, University of California Riverside
• Dr Sean Sweeney, University of York
• Dr Cathy Fernandes, King's College London