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Josephine Eum

Research Assistant


In her current position, she’s working on a project investigating the functional outcomes of engaging human ab T cells using humanised antibodies specific for individual Vb regions. This work has led to the identification of a unique T-cell activation phenotype in vitro and in vivo which has significant translational value relating to cancer immunotherapy. In the course of this work, she has utilised several omics-based approaches (primarily scRNA-seq and high dimensional flow cytometry), which have highlighted a novel T-cell functional phenotype induced using these candidate therapeutic agents alongside very clear signatures linking immunometabolism and immune function in this setting. She is very keen to explore this further and understand how it relates to other areas of disease pathology and translational immunology.