Professor Karl Peter Giese PhD

Biography

I am investigating memory mechanisms in health and disease and currently my research addresses:

1. The molecular and cellular basis of memory storage in young and old age.
2. Mechanisms of synaptic dysregulation in the early stages of Alzheimer's disease.
3. Modelling intellectual disability in mice.

I have published over 100 publications, edited two books on memory mechanisms, and organised several international symposia on molecular and cellular memory processes. My most widely recognised work is on the role of calcium/calmodulin-dependent kinase II in learning and memory.

Please see my Research Staff Profile for more detail.

Key Publications:

• Ghosh et al (2020). Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Transl. Psychiatry 
• Aziz et al. (2019). Multi-input synapses, but not LTP-strengthened synapses, correlate with hippocampal memory storage in aged mice. Curr. Biol. 
• Tiwari et al., 2016. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain.
• Radwanska et al., 2011. Mechanism of long-term memory formation when synaptic strengthening is impaired. Proceedings of the National Academy of Sciences.
• Engmann et al (2011). Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain 

View all publications

Key Collaborators:

• Prof. Albert Basson, King's College London
• Prof. Deepak Srivastava, King's College London
• Dr Wendy Noble, King's College London
• Professor Ted Abel, University of Iowa