Mark Mcphail Dr Mark McPhail Academics Supervisors Reader in Experimental Medicine Research subject areas Biomedical and life sciences Contact details mark.mcphail@kcl.ac.uk @drmarkmcphail 07932798003
Adrenomedullin as an immunomodulator of CD14+MerTK+ circulating monocytes in liver failure syndromes Cell cycle arrest biomarkers for early diagnosis of acute kidney injury after liver transplantation: A prospective cohort study Circulating monocytes upregulate CD52 and sustain innate immune function in cirrhosis unless acute decompensation emerges Is it time to open the doors of the intensive care unit further for patients with alcohol-related liver disease? Lipidomics-based plasma signature of alcohol-related hepatitis linked to short-term mortality Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center Rapid response teams and recommended ward-based management of acute deterioration: a single-centre retrospective cohort study in an inner-city London (UK) teaching hospital Rising rates of sepsis in England: an ecological study Survival with and without liver transplantation in critically ill patients with cirrhosis: A 20-Year Experience Autotaxin upregulation in liver failure and the effect on monocyte phenotype and function is a pan-aetiology phenomenon Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial Cis-interaction between CD52 and T cell receptor complex interferes with CD4+ T cell activation in acute decompensation of cirrhosis Cis-interaction between CD52 and T cell receptor complex interferes with CD4 + T cell activation in acute decompensation of cirrhosis. Immunopathogenesis of acute on chronic liver failure Liver Elastography in Acute Liver Failure: A Pilot Study Liver transplantation for acute-on-chronic liver failure Macrophage activation markers are associated with infection and mortality in patients with acute liver failure microRNA associated with hepatocyte injury and systemic inflammation may predict adverse outcomes in cirrhotic patients Oral-gut microbiome interactions in advanced cirrhosis: characterisation of pathogenic enterotypes and salivatypes, virulence factors and antimicrobial resistance A second update on mapping the human genetic architecture of COVID-19 Carvedilol in patients with compensated cirrhosis: The ongoing benefits of definitive randomised trials over meta-analysis in patients with small varices Erratum to: Mapping the human genetic architecture of COVID-19 (Nature, (2021), 600, 7889, (472-477), 10.1038/s41586-021-03767-x) Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure Potential therapies for acute-on-chronic liver failure Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity Diagnostic accuracy of procalcitonin and interleukin-6 for postoperative infection in major gastrointestinal surgery: a systematic review and meta-analysis General practitioner perspectives on factors that influence implementation of secondary care-initiated treatment in primary care: Exploring implementation beyond the context of a clinical trial General Practitioner perspectives on factors that influence implementation of secondary care-initiated treatment in primary care: exploring implementation beyond the context of a clinical trial High plasma level of osteopontin, a potential biomarker in hepatocellular carcinoma, is associated with weakened anti-tumour immunity Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes Lipids in Liver Failure Syndromes: A Focus on Eicosanoids, Specialized Pro-Resolving Lipid Mediators and Lysophospholipids Low Baseline but Not Delta Cortisol Relates to 28-Day Transplant-Free Survival in Acute and Acute-on-Chronic Liver Failure Rifaximin reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial Systematic review and meta-analysis of the diagnostic accuracy of procalcitonin for post-operative sepsis/infection in liver transplantation Using a theory-informed approach to explore patient and staff perspectives on factors that influence clinical trial recruitment for patients with cirrhosis and small oesophageal varices Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure Association of cardiometabolic microRNAs with COVID-19 severity and mortality Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute-on-Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid–Dependent Monocyte Activation Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry Low baseline cortisol but not delta cortisol relates to 28-day transplant-free survival in acute liver failure syndromes Mapping the human genetic architecture of COVID-19 Margin ACcentuation for resectable Pancreatic cancer using Irreversible Electroporation-Results from the MACPIE-I study Microcirculatory, Endothelial, and Inflammatory Responses in Critically Ill Patients With COVID-19 Are Distinct From Those Seen in Septic Shock: A Case Control Study Mitochondrial dysfunction as a mechanistic biomarker in patients with non-alcoholic fatty liver disease (NAFLD) Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19 OSTEOPONTIN, MACROPHAGE MANNOSE RECEPTOR AND SOLUBLE PD-L1 ARE UPREGULATED MACROPHAGE ACTIVATION MARKERS IN PATIENTS WITH ACUTE LIVER FAILURE PARTIAL SPLENIC ARTERY EMBOLISATION FOR PORTAL HYPERTENSION - A SINGLE CENTRE EXPERIENCE Patterns and prediction of liver injury with persistent cholestasis in survivors of severe SARS-CoV-2 infection PD-L1 expression of monocytes relates to severity, infection and mortality in acute-on-chronic liver failure View all publications
6 July 2020 Quest for biomarkers in blood samples of COVID-19 patients to better understand host response Researchers from the School of Cardiovascular Medicine & Sciences have been analysing blood samples…