Matt is an Electron Microscopy Applications Specialist at the King’s Centre for Electron Microscopy (KCEM). His expertise includes transmission and scanning electron microscopy, correlative light and electron microscopy (CLEM), volume and thin-section EM, serial block-face scanning electron microscopy, transmission electron tomography, image analysis, and image modelling.

He began his journey in electron microscopy in 2001, studying cell membrane transport. Since then, he has applied advanced imaging approaches to a broad range of biological questions and has worked in dedicated EM core facilities since 2013, supporting researchers across a wide range of disciplines including cancer biology, neuroscience, infectious diseases, host–pathogen interactions, and parasitology.

Matt develops and applies advanced imaging workflows that enable researchers to visualise biological systems across multiple spatial scales. His interests include correlative imaging approaches, three-dimensional ultrastructural analysis, automated data acquisition, and quantitative image analysis.

He enjoys using automation to facilitate batch imaging and montaging, batch TEM tomography, correlative navigation, and other volume EM techniques.

His publication record includes journal covers and publications in Science and other high impact journals. He has been lead author as a PhD student, a postdoc, and as a facility staff member, on cell membrane transport and on methods for correlative volume electron microscopy workflows. Matt has also published work with facility users involving a range of approaches, including quantitation of HMCV capsids to assess the bioactivity of bisbenzimide compounds, quantitation of ER-mitochondria contact sites to investigate the function of a protein involved in Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia, and correlative EM, LM, and mass spectrometry imaging (NanoSIMS) of an antibiotic in bacteria and associated organelles in Mycobacterium tuberculosis-infected cells.