Matt’s PhD and postdoctoral research used transmission electron microscopy and tomography to examine how disruption of ESCRTs impairs endosome biogenesis in yeast and animal cells. 

This background in intracellular membrane biology helped Matt to address a range of biological questions at the subcellular level in his role at The Francis Crick Institute, Electron Microscopy Science Technology Platform. This often involved infectious agents like mycobacteria and apicomplexan parasites. Matt enjoys using correlative approaches to help understand features from multiple points of view, combining electron microscopy data (often in 3D) with data from light microscopes, microanalysis, and other types of electron microscope. Matt is also interested in how features from volume EM images can be modelled, and those models analysed to extract meaningful data.

Matt joined CUI in 2021 to continue applying and developing these approaches.