Dr Natalie Prescott PhD Academics Supervisors Senior Lecturer Research subject areas Biomedical and life sciences Contact details natalie.prescott@kcl.ac.uk +44 (0) 20 7848 8513 @natter5
Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine Conserved gd T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility A Crohn’s Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling Reply Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population Genetic and Inflammatory Biomarkers Classify Small Intestine Inflammation in Asymptomatic First-degree Relatives of Patients With Crohn's Disease IBD BioResource: An Open-Access Platform of 25 000 Patients to Accelerate Research in Crohn's and Colitis Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn's Disease? Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer Exome Sequencing and Genotyping Identify a Rare Variant in NLRP7 Gene Associated With Ulcerative Colitis Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn's disease Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations Defective macrophage handling of Escherichia coli in Crohn's disease Lamina propria macrophage phenotypes in relation to Escherichia coli in Crohn's disease Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes The unusual suspects-innate lymphoid cells as novel therapeutic targets in IBD Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population Effect of communicating DNA based risk assessments for Crohn's disease on smoking cessation: randomised controlled trial Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease MICROBIAL, PHENOTYPIC AND GENETIC MARKERS OF RISK: ASPECTS OF CROHN'S DISEASE THAT ARE SHARED BY UNAFFECTED SIBLINGS Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry Seven newly identified loci for autoimmune thyroid disease Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota TOWARDS INDIVIDUALISED RISK PREDICTION FOR CROHN'S DISEASE Accuracy and differential bias in copy number measurement of CCL3L1 in association studies with three auto-immune disorders Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study AUTOPHAGY GENE POLYMORPHISMS INFLUENCE THE INTERACTION OF E COLI AND MACROPHAGES IN CROHN'S DISEASE Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa Screening for rare pathogenic sequence variants in inflammatory bowel disease An evaluation of the genetic relationship between Orofacial Granulomatosis and Crohn's Disease DEMOGRAPHIC, CLINICAL AND GENETIC FACTORS ASSOCIATED WITH DYSBIOSIS IN PATIENTS WITH ACTIVE CROHN'S DISEASE Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease A FUNCTIONAL STUDY OF THE EFFECT OF THE 14 BP INSERTION DELETION POLYMORPHISM OF THE HLA-G GENE ON RESPONSE TO IMMUNOMODULATORY THERAPY IN INFLAMMATORY BOWEL DISEASE Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship IN VITRO RESPONSES OF MACROPHAGES TO E COLI CHALLENGE IN CROHN'S DISEASE View all publications
Description Natalie is a course leader for the following courses: Molecular Basis of Gene Expression (5BBG0205) Molecular Biology Research Skills (5BBG0206) Natalie is a teacher on the following courses: Complex Disease Genetics (6BBYG306) Extended Research Project in Genetics (6BBG0303) Human and Molecular Genetics (5BBG0204)