
Professor Oliver Howes
Professor of Molecular Psychiatry
- Head of Department, Psychosis Studies
Research interests
- Mental Health
- Psychiatry
Contact details
Biography
Oliver Howes is Head of Department, Psychosis Studies and Professor of Molecular Psychiatry at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London.
His clinical work is as a Consultant Psychiatrist at the Maudsley Hospital, London, where he runs a team for people with difficult to treat psychotic disorders. This includes helping people where treatment hasn't worked, or with side-effects.
He heads the Psychiatric Imaging Group. The group investigates the neurobiology of major mental illnesses and the development of novel treatments. It focuses on the translation of basic science findings into first in human and early phase clinical studies. The group also investigates how to improve treatment, including implementing novel service approaches, and physical health comorbidities.
He has been named as one the world's leading scientists in both psychiatry and neuroscience by ISI Thompson on the basis of high impact publications over the last decade. His work has been recognised by a number of awards, including the Schizophrenia International Research Society Translational Research Award 2024 and the Robert Sommer Translational Science Award 2025. Faculty 1000 has identified 10 papers as outstanding & Science Watch identified two papers as amongst the top six in psychiatry by citations for the year.
The group’s preclinical work involves the development of novel radiotracers and pharmacological probes to take into human studies and the development of preclinical models of the neurobiology of major mental illnesses.
These include developmental, genetic, and pharmacological rat and mouse models, including sub-chronic ketamine, cocaine and chemogenetic (DREADD) challenges. The group uses a variety of in vivo and ex vivo techniques including behavioural testing, PET imaging in mice and rats with and without blocking agents, autoradiography, confocal microscopy, and immuno-histochemistry.
The group’s human work focuses on experimental medicine studies in patient cohorts and healthy volunteers. Approaches include in vivo imaging with PET, fMRI, and MRS coupled with pharmacological or behavioural challenges. The group uses a number of functional and pharmacological challenge procedures, for example to target the immune, serotinergic, dopaminergic and cannabinoid systems.
In addition the group conducts first in human and first in disorder studies with new drugs and radiotracers, including in vivo validation using blocking agents and pharmacokinetic modelling. This has involved developing novel modelling approaches and methodological developments. The group also conducts studies on imaging and blood based biomarkers for stratification of disorders.
Deciphering Histamine Pathway Networks in the Human Brain: A Multimodal Approach to Cognition and Psychiatric Disorders
Martins, D., Veronese, M., van Wamelen, D., Shan, L., Howes, O., Hampshire, A., Turkheimer, F. & Williams, S., 7 Apr 2025, (Submitted).Research output: Working paper/Preprint › Preprint
Glucagon-like peptide 1 receptor agonists and mental health: A systematic review and meta-analysis
Pierret, A., Mizuno, Y., Saunders, P., Lim, E., De Giorgi, R., Howes, O., McCutcheon, R., McGowan, B., Sen Gupta, P., Smith, D., Ismail, K. & Pillinger, T., 25 Feb 2025, (Accepted/In press) In: JAMA Psychiatry.Research output: Contribution to journal › Article › peer-review
Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging
the FDOPA PET imaging working group, 28 Feb 2025, (E-pub ahead of print) In: Molecular Psychiatry. e72904.Research output: Contribution to journal › Article › peer-review
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour
Osugo, M., Wall, M. B., Selvaggi, P., Zahid, U., Finelli, V., Chapman, G. E., Whitehurst, T., Onwordi, E. C., Statton, B., McCutcheon, R. A., Murray, R. M., Marques, T. R., Mehta, M. A. & Howes, O. D., 21 Feb 2025, In: Nature Communications. 16, 1, 1852.Research output: Contribution to journal › Article › peer-review
Synaptic density marker, SV2A, is reduced in autistic adults: BPNA 2025 Annual Conference, Abstracts of the Annual Meeting, 8-10 January 2025, Oxford, UK
Mehra, C., Onwordi, E. C., Shatalina, E., Kowalewska, B., Whitehurst, T., Griffioen-Jarfalk, G., Martins, R., Petrinovic, M.-M., Mouga, S., Abrunhosa, A., Pina Rodrigues, A., Castello-Branco, M., Borg, J., Natesan, S., O'Muircheartaigh, J., Howes, O. & Murphy, D., Jan 2025, Developmental Medicine & Child Neurology. Mac Keith Press, Vol. 67. p. 23-136 114 p. (Developmental medicine and child neurology).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
Transcriptional and Neurochemical Signatures of Cerebral Blood Flow Alterations in Individuals With Schizophrenia or at Clinical High Risk for Psychosis
Knight, S. R., Abbasova, L., Zeighami, Y., Hansen, J. Y., Martins, D., Zelaya, F., Dipasquale, O., Liu, T., Shin, D., Bossong, M., Azis, M., Antoniades, M., Howes, O. D., Bonoldi, I., Egerton, A., Allen, P., O'Daly, O., McGuire, P. & Modinos, G., 7 Feb 2025, (E-pub ahead of print) In: Biological psychiatry. 12 p.Research output: Contribution to journal › Article › peer-review
Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and individuals at clinical high-risk for psychosis
Knight, S., Abbasova, L., Zeighami, Y., Hansen, J., Martins, D., Zelaya, F., Dipasquale, O., Liu, T., Shin, D., Bossong, M., Azis, M., Antoniades, M., Howes, O., Bonoldi, I., Egerton, A., Allen, P., O'Daly, O., McGuire, P. & Modinos, G., 3 Feb 2025, (Accepted/In press) In: Biological psychiatry.Research output: Contribution to journal › Article › peer-review
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis
Rogdaki, M., McCutcheon, R. A., D'Ambrosio, E., Mancini, V., Watson, C. J., Fanshawe, J. B., Carr, R., Telesia, L., Martini, M. G., Philip, A., Gilbert, B. J., Salazar-de-Pablo, G., Kyriakopoulos, M., Siskind, D., Correll, C. U., Cipriani, A., Efthimiou, O., Howes, O. D. & Pillinger, T., Jul 2024, In: The Lancet Child & Adolescent Health. 8, 7, p. 510-521 12 p.Research output: Contribution to journal › Article › peer-review
Generative-Model-Based Fully 3D PET Image Reconstruction by Conditional Diffusion Sampling
Webber, G., Mizuno, Y., Howes, O., Hammers, A., King, A. & Reader, A., 25 Sept 2024, In: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD).Research output: Contribution to journal › Conference paper › peer-review
Histamine-3 Receptor Availability and Glutamate Levels in the Brain: A PET-1H-MRS Study of Patients With Schizophrenia and Healthy Controls
Arumuham, A., Nour, M. M., Veronese, M., Beck, K., Onwordi, E. C., Lythgoe, D. J., Jauhar, S., Rabiner, E. A. & Howes, O. D., 1 Mar 2024, In: International Journal of Neuropsychopharmacology. 27, 3, pyae011.Research output: Contribution to journal › Article › peer-review
Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study
Shatalina, E., Whitehurst, T. S., Onwordi, E. C., Gilbert, B. J., Rizzo, G., Whittington, A., Mansur, A., Tsukada, H., Marques, T. R., Natesan, S., Rabiner, E. A., Wall, M. B. & Howes, O. D., Dec 2024, In: EJNMMI Research. 14, 1, 41.Research output: Contribution to journal › Article › peer-review
Mortality associated with clozapine: What is the evidence?
Fernandez-Egea, E., Flanagan, R. J., Taylor, D., Gaughran, F., Lawrie, S. M., Jenkins, C., Smith, S., Howes, O. D. & MacCabe, J. H., 1 Sept 2024, In: British Journal of Psychiatry. 225, 3, p. 357-359 3 p.Research output: Contribution to journal › Editorial › peer-review
Multi-Subject Image Synthesis as a Generative Prior for Single-Subject PET Image Reconstruction
Webber, G., Mizuno, Y., Howes, O., Hammers, A., King, A. & Reader, A., 25 Sept 2024, In: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD).Research output: Contribution to journal › Conference paper › peer-review
Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis
Siafis, S., Nomura, N., Schneider-Thoma, J., Bighelli, I., Bannach-Brown, A., Ramage, F. J., Tinsdeall, F., Mantas, I., Jauhar, S., Natesan, S., Vernon, A. C., de Bartolomeis, A., Hölter, S. M., Drude, N. I., Tölch, U., Hansen, W.-P., Chiocchia, V., Howes, O. D., Priller, J. & Macleod, M. R. & 2 others, Salanti, G. & Leucht, S., 15 Jan 2024, In: F1000Research. 13, p. 1017Research output: Contribution to journal › Article › peer-review
New Drug Treatments for Schizophrenia: A Review of Approaches to Target Circuit Dysfunction
Howes, O. D., Dawkins, E., Lobo, M. C., Kaar, S. J. & Beck, K., 1 Oct 2024, In: Biological psychiatry. 96, 8, p. 638-650Research output: Contribution to journal › Article › peer-review
Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow
Sun, J., Zelaya, F., Sendt, K. V., McQueen, G., Gillespie, A. L., Lally, J., Howes, O. D., Barker, G. J., McGuire, P., MacCabe, J. H. & Egerton, A., 23 Dec 2024, In: NPJ SCHIZOPHRENIA. 10, 1, 122.Research output: Contribution to journal › Article › peer-review
Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A
Onwordi, E. C., Whitehurst, T., Shatalina, E., Mansur, A., Arumuham, A., Osugo, M., Marques, T. R., Jauhar, S., Gupta, S., Mehrotra, R., Rabiner, E. A., Gunn, R. N., Natesan, S. & Howes, O. D., 1 Apr 2024, In: Biological psychiatry. 95, 7, p. 639-646 8 p.Research output: Contribution to journal › Article › peer-review
Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis
Knight, S., Abbasova, L., Zeighami, Y., Hansen, J. Y., Martins, D., Zelaya, F., Dipasquale, O., Liu, T., Shin, D., Bossong, M., Azis, M., Antoniades, M., Howes, O., Bonoldi, I., Egerton, A., Allen, P., O'Daly, O., McGuire, P. & Modinos, G., 14 Mar 2024.Research output: Working paper/Preprint › Preprint
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Jauhar, S., Arnone, D., Baldwin, D. S., Bloomfield, M., Browning, M., Cleare, A. J., Corlett, P., Deakin, J. F. W., Erritzoe, D., Fu, C., Fusar-Poli, P., Goodwin, G. M., Hayes, J., Howard, R., Howes, O. D., Juruena, M. F., Lam, R. W., Lawrie, S. M., McAllister-Williams, H. & Marwaha, S. & 15 others, Matuskey, D., McCutcheon, R. A., Nutt, D. J., Pariante, C., Pillinger, T., Radhakrishnan, R., Rucker, J., Selvaraj, S., Stokes, P., Upthegrove, R., Yalin, N., Yatham, L., Young, A. H., Zahn, R. & Cowen, P. J., Aug 2023, In: Molecular Psychiatry. 28, 8, p. 3149-3152 4 p.Research output: Contribution to journal › Comment/debate › peer-review
Antidepressant and antipsychotic side-effects and personalised prescribing: a systematic review and digital tool development
Pillinger, T., Howes, O. D., Correll, C. U., Leucht, S., Huhn, M., Schneider-Thoma, J., Gaughran, F., Jauhar, S., McGuire, P. K., Taylor, D. M., Young, A. H. & McCutcheon, R. A., 1 Nov 2023, In: The lancet. Psychiatry. 10, 11, p. 860-876 17 p.Research output: Contribution to journal › Article › peer-review
Dopamine in major depressive disorder: A systematic review and meta-analysis of in vivo imaging studies
Mizuno, Y., Ashok, A., Bhaskar Bhat, B., Jauhar, S. & Howes, O., 23 Aug 2023, (Accepted/In press) In: Journal of Psychopharmacology.Research output: Contribution to journal › Article › peer-review
Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study
Pillinger, T., Osimo, E. F., de Marvao, A., Shah, M., Francis, C., Huang, J., D'Ambrosio, E., Firth, J., Nour, M. M., McCutcheon, R. A., Pardiñas, A. F., Matthews, P. M., O'Regan, D. P. & Howes, O. D., Feb 2023, In: The Lancet Psychiatry. 10, 2, p. 98-107 10 p.Research output: Contribution to journal › Article › peer-review
Low-frequency monitoring for community clozapine initiations: a comparative study relative to standard frequency assessments
Mizuno, Y., Butler, E., Bonoldi, I., Taylor, D. & Howes, O., 1 Apr 2023, (Accepted/In press) In: Journal of Psychopharmacology.Research output: Contribution to journal › Letter › peer-review
Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
Howes, O. D., Cummings, C., Chapman, G. E. & Shatalina, E., Jan 2023, In: Neuropsychopharmacology. 48, 1, p. 151-167 17 p.Research output: Contribution to journal › Review article › peer-review
Parsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study
Oliver, D., Davies, C., Zelaya, F., Selvaggi, P., De Micheli, A., Catalan, A., Baldwin, H., Arribas, M., Modinos, G., Crossley, N. A., Allen, P., Egerton, A., Jauhar, S., Howes, O. D., McGuire, P. & Fusar-Poli, P., 2023, In: Frontiers in Psychiatry. 14, 1092213.Research output: Contribution to journal › Article › peer-review
Schizophrenia: from neurochemistry to circuits, symptoms and treatments
Howes, O., Bukala, B. & Beck, K., 18 Dec 2023, In: Nature Reviews Neurology. 20, p. 22-35Research output: Contribution to journal › Review article › peer-review
Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A)
Onwordi, E. C., Whitehurst, T., Shatalina, E., Mansur, A., Arumuham, A., Osugo, M., Reis Marques, T., Jauhar, S., Gupta, S., Mehrotra, R., Rabiner, E. A., Gunn, R. N., Natesan, S. & Howes, O., 23 May 2023, (Accepted/In press) In: Biological psychiatry.Research output: Contribution to journal › Article › peer-review
The association between peripheral inflammation, brain glutamate and antipsychotic response in Schizophrenia: Data from the STRATA collaboration
Fenn-Moltu, S., Deakin, B., Drake, R., Howes, O. D., Lawrie, S. M., Lewis, S., Nikkheslat, N., Walters, J. T. R., MacCabe, J. H., Mondelli, V. & Egerton, A., Jul 2023, In: Brain Behavior and Immunity. 111, p. 343-351 9 p.Research output: Contribution to journal › Article › peer-review
The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia
Arumuham, A., Nour, M. M., Veronese, M., Onwordi, E. C., Rabiner, E. A. & Howes, O. D., Oct 2023, In: Journal of Psychopharmacology. 37, 10, p. 1011-1022 12 p.Research output: Contribution to journal › Article › peer-review
The Synaptic Hypothesis of Schizophrenia Version III: A Master Mechanism
Howes, O. & Onwordi, E. C., 20 Mar 2023, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Review article › peer-review
Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
Merritt, K., McCutcheon, R. A., Aleman, A., Ashley, S., Beck, K., Block, W., Bloemen, O. J. N., Borgan, F., Boules, C., Bustillo, J. R., Capizzano, A. A., Coughlin, J. M., David, A., de la Fuente-Sandoval, C., Demjaha, A., Dempster, K., Do, K. Q., Du, F., Falkai, P. & Galińska-Skok, B. & 30 others, Gallinat, J., Gasparovic, C., Ginestet, C. E., Goto, N., Graff-Guerrero, A., Ho, B.-C., Howes, O., Jauhar, S., Jeon, P., Kato, T., Kaufmann, C. A., Kegeles, L. S., Keshavan, M. S., Kim, S.-Y., King, B., Kunugi, H., Lauriello, J., León-Ortiz, P., Liemburg, E., Mcilwain, M. E., Modinos, G., Mouchlianitis, E., Nakamura, J., Nenadic, I., Öngür, D., Ota, M., Palaniyappan, L., Stone, J., McGuire, P. & Egerton, A., May 2023, In: Molecular Psychiatry. 28, 5, p. 2039-2048 10 p.Research output: Contribution to journal › Article › peer-review
What is the duration of untreated psychosis worldwide? - A meta-analysis of pooled mean and median time and regional trends and other correlates across 369 studies.
Salazar de Pablo, G., Aymerich, C., Guinart, D., Catalan, A., Alameda, L., Trotta, G., Armendariz, A., Baringo, E. M., Soler-Vidal, J., Rubio, J. M., Garrido-Torres, N., Gomez Vallejo, S., Kane, J. M., Howes, O., Fusar-Poli, P. & Correll, C. U., 18 Nov 2023, (Accepted/In press) In: Psychological medicine.Research output: Contribution to journal › Review article › peer-review
A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia
Osimo, E. F., Brugger, S. P., Thomas, E. L. & Howes, O. D., 18 Mar 2022, In: NPJ SCHIZOPHRENIA. 8, 1, 24.Research output: Contribution to journal › Article › peer-review
A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia
Correll, C. U., Agid, O., Crespo-Facorro, B., de Bartolomeis, A., Fagiolini, A., Seppälä, N. & Howes, O. D., Jul 2022, In: CNS Drugs. 36, 7, p. 659-679 21 p.Research output: Contribution to journal › Article › peer-review
A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function
D'Ambrosio, E., Pergola, G., Pardiñas, A. F., Dahoun, T., Veronese, M., Sportelli, L., Taurisano, P., Griffiths, K., Jauhar, S., Rogdaki, M., Bloomfield, M. A., Froudist-Walsh, S., Walters, J. T., Blasi, G., Bertolino, A. & Howes, O., 23 Jul 2022, In: Scientific Reports. 12, 1, 12610.Research output: Contribution to journal › Article › peer-review
Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies
Ribeiro, D., Hallett, W., Howes, O., McCutcheon, R., Nour, M. M. & Tavares, A. A. S., 20 Feb 2022, In: EJNMMI Research. 12, 1, 11.Research output: Contribution to journal › Article › peer-review
Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity
Reid, M., Rogdaki, M., Dutan Polit, L., Hanger, B., Sabad, K., Nagy, R., Adhya, D., Baron-Cohen, S., McAlonan, G., Price, J., Vernon, A., Howes, O. & Srivastava, D., 14 May 2022, (Accepted/In press) In: Schizophrenia Research.Research output: Contribution to journal › Article › peer-review
Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art
Harvey, P. D., Bosia, M., Cavallaro, R., Howes, O. D., Kahn, R. S., Leucht, S., Müller, D. R., Penadés, R. & Vita, A., Sept 2022, In: Schizophrenia Research: Cognition. 29, 100249.Research output: Contribution to journal › Article › peer-review
Cognitive function and treatment response trajectories in first-episode schizophrenia: evidence from a prospective cohort study
Millgate, E., Griffiths, K., Egerton, A., Kravariti, E., Casetta, C., Deakin, B., Drake, R., Howes, O. D., Kassoumeri, L., Khan, S., Lankshear, S., Lees, J., Lewis, S., Mikulskaya, E., Oloyede, E., Owens, R., Pollard, R., Rich, N., Smart, S. & Segev, A. & 2 others, Verena Sendt, K. & MacCabe, J., 21 Nov 2022, In: BMJ Open. 12, 11, e062570.Research output: Contribution to journal › Article › peer-review
Dopamine partial agonists and prodopaminergic drugs for schizophrenia: Systematic review and meta-analysis of randomized controlled trials
Osugo, M., Whitehurst, T., Shatalina, E., Townsend, L., O'Brien, O., Mak, T. L. A., McCutcheon, R. & Howes, O., 30 Apr 2022, In: Neuroscience and Biobehavioral Reviews. 135, 104568.Research output: Contribution to journal › Review article › peer-review
Efficacy and safety of Lu AF35700 in treatment-resistant schizophrenia: A randomized, active-controlled trial with open-label extension
the DayBreak and Debut study investigators, 1 Oct 2022, In: Schizophrenia Research. 248, p. 271-278 8 p.Research output: Contribution to journal › Article › peer-review
Emerging Treatments in Schizophrenia
Correll, C. U., Abi-Dargham, A. & Howes, O., Jan 2022, In: Journal of Clinical Psychiatry. 83, 1, SU21024IP1.Research output: Contribution to journal › Article › peer-review
Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
Halff, E. F., Natesan, S., Bonsall, D. R., Veronese, M., Garcia-Hidalgo, A., Kokkinou, M., Tang, S. P., Riggall, L. J., Gunn, R. N., Irvine, E. E., Withers, D. J., Wells, L. A. & Howes, O. D., 2022, In: Molecular Imaging. 2022, 4419221.Research output: Contribution to journal › Article › peer-review
Evaluation of intraperitoneal [18F]-FDOPA administration for micro-PET imaging in mice and assessment of the effect of sub-chronic ketamine dosing on dopamine synthesis capacity
Halff, E., Natesan, S., Bonsall, D. R., Veronese, M., Garcia-Hidalgo, A., Kokkinou, M., Tang, S.-P., Riggall , L., Gunn, R., Irvine, E., Withers, D., Wells, L. & Howes, O., 8 Oct 2022, (Accepted/In press) In: Molecular Imaging. 4419221.Research output: Contribution to journal › Article › peer-review
Impaired verbal memory function is related to anterior cingulate glutamate levels in schizophrenia: findings from the STRATA study
Griffiths, K., Egerton, A., Millgate, E., Anton, A., Barker, G. J., Deakin, B., Drake, R., Eliasson, E., Gregory, C. J., Howes, O. D., Kravariti, E., Lawrie, S. M., Lewis, S., Lythgoe, D. J., Murphy, A., McGuire, P., Semple, S., Stockton-Powdrell, C., Walters, J. T. R. & Williams, S. R. & 1 others, MacCabe, J. H., 12 Jul 2022, In: Schizophrenia. 8, 1, p. 60 60.Research output: Contribution to journal › Article › peer-review
Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance
Howes, O. D. & Shatalina, E., 15 Sept 2022, In: Biological psychiatry. 92, 6, p. 501-513 13 p.Research output: Contribution to journal › Review article › peer-review
Low COVID-19 vaccination rates in people with severe mental illness and reasons for this: An out-patient study
Arumuham, A., O’Brien, O., Ahmad, Z., Nikbin, K. & Howes, O. D., Apr 2022, In: Acta Psychiatrica Scandinavica. 145, 4, p. 416-418 3 p.Research output: Contribution to journal › Article › peer-review
New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics
Lobo, M. C., Whitehurst, T. S., Kaar, S. J. & Howes, O. D., Jan 2022, In: Neuroscience and Biobehavioral Reviews. 132, p. 324-361 38 p.Research output: Contribution to journal › Review article › peer-review
Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis
PRONIA Consortium, Howes, O. & Koutsouleris, N., 9 Mar 2022, In: Schizophrenia. 8, 1, p. 19Research output: Contribution to journal › Article › peer-review
Real-world clinical and cost-effectiveness of community clozapine initiation: mirror cohort study
Butler, E., Pillinger, T., Brown, K., Borgan, F., Bowen, A., Beck, K., D'Ambrosio, E., Jauhar, S., Kaar, S., McCutcheon, R., Rogdaki, M., Gaughran, F., Maccabe, J., Ramsay, R., McCrone, P., Egerton, A. & Howes, O., 11 Dec 2022, In: British Journal of Psychiatry. 221, 6, p. 740-747 8 p.Research output: Contribution to journal › Article › peer-review
Research

STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances
People with schizophrenia suffer from a range of symptoms including hallucinations (such as hearing voices), delusions (false beliefs) and thought disorder (thoughts not flowing in a logical way).

UNIQUE Research Group
UNIQUE Research group carries out a range of sudies involving people who experience persistent, full-blown psychotic experiences but are not in need of care

ATLANTIS - AnTiconvuLsant AugmeNtation Trial In Schizophrenia
NIHR funded multi-centre clinical trial evaluating valproate augmentation of antipsychotic medication in the management of psychosis
News
Obesity drugs found to improve emotional wellbeing as well as physical health
A major new meta-analysis from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that glucagon-like peptide 1...

Professors Oliver Howes and Marta Di Forti presented with Schizophrenia Research Society Outstanding Translational Research Awards
Professor Howes and Professor Di Forti were presented their awards on 29 March 2025 at the 2025 Congress of the Schizophrenia International Research Society...

Researchers receive £4.1million to research new modelling and treatment approaches for auditory hallucinations in people with psychosis
The Wellcome Trust Mental Health Award will fund testing of a computational model of the role of cortical circuits in understanding auditory hallucinations...

New tool to streamline prescribing of antidepressants
A new web tool has been designed by researchers at King's College London and the University of Oxfordto simplify the prescription of antidepressant and...

'When the drugs don't work: the challenge of treatment resistant psychosis'
Professor James MacCabe delivered the ninth inaugural lecture of the 2022/23 IoPPN Inaugural Lecture Series, entitled 'When the drugs don’t work: the...

Oliver Howes receives the ACNP Joel Elkes Research Award
The American College of Neuropsychopharmacology (ACNP) has named Professor Oliver Howes as the recipient of the 2022 Joel Elkes Research Award.

Two IoPPN Professors elected as new Fellows of the Academy of Medical Sciences
Professor Oscar Marín and Professor Oliver Howes from the Institute of Psychiatry, Psychology & Neuroscience at King’s have been elected to the prestigious...

Events

Dr Paul Janssen Lecture: Neuroinflammation and psychosis: a new dawn or bleak midwinter?
A Dr Paul Janssen lecture with Rachel Upthegrove MBE, Professor of Psychiatry in the Department of Psychiatry, University of Oxford.
Please note: this event has passed.

Unveil Psychosis Heterogeneity: Stratification via Circuit-Based Biomarkers
A Paul Janssen lecture with Professor Kim Q. Do, Professor of Translational Psychiatry at Lausanne University, Switzerland.
Please note: this event has passed.

Professor James MacCabe - Inaugural Lecture
Join us in celebrating Professor James MacCabe's inaugural lecture on 'When the drugs don't work: the challenge of treatment resistant psychosis'
Please note: this event has passed.
Features
IoPPN Inaugural Lectures: 2017-2019
Inaugural lectures are given by newly arrived or promoted professors, who use the opportunity to introduce themselves, to present an overview of their own...

Deciphering Histamine Pathway Networks in the Human Brain: A Multimodal Approach to Cognition and Psychiatric Disorders
Martins, D., Veronese, M., van Wamelen, D., Shan, L., Howes, O., Hampshire, A., Turkheimer, F. & Williams, S., 7 Apr 2025, (Submitted).Research output: Working paper/Preprint › Preprint
Glucagon-like peptide 1 receptor agonists and mental health: A systematic review and meta-analysis
Pierret, A., Mizuno, Y., Saunders, P., Lim, E., De Giorgi, R., Howes, O., McCutcheon, R., McGowan, B., Sen Gupta, P., Smith, D., Ismail, K. & Pillinger, T., 25 Feb 2025, (Accepted/In press) In: JAMA Psychiatry.Research output: Contribution to journal › Article › peer-review
Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging
the FDOPA PET imaging working group, 28 Feb 2025, (E-pub ahead of print) In: Molecular Psychiatry. e72904.Research output: Contribution to journal › Article › peer-review
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour
Osugo, M., Wall, M. B., Selvaggi, P., Zahid, U., Finelli, V., Chapman, G. E., Whitehurst, T., Onwordi, E. C., Statton, B., McCutcheon, R. A., Murray, R. M., Marques, T. R., Mehta, M. A. & Howes, O. D., 21 Feb 2025, In: Nature Communications. 16, 1, 1852.Research output: Contribution to journal › Article › peer-review
Synaptic density marker, SV2A, is reduced in autistic adults: BPNA 2025 Annual Conference, Abstracts of the Annual Meeting, 8-10 January 2025, Oxford, UK
Mehra, C., Onwordi, E. C., Shatalina, E., Kowalewska, B., Whitehurst, T., Griffioen-Jarfalk, G., Martins, R., Petrinovic, M.-M., Mouga, S., Abrunhosa, A., Pina Rodrigues, A., Castello-Branco, M., Borg, J., Natesan, S., O'Muircheartaigh, J., Howes, O. & Murphy, D., Jan 2025, Developmental Medicine & Child Neurology. Mac Keith Press, Vol. 67. p. 23-136 114 p. (Developmental medicine and child neurology).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
Transcriptional and Neurochemical Signatures of Cerebral Blood Flow Alterations in Individuals With Schizophrenia or at Clinical High Risk for Psychosis
Knight, S. R., Abbasova, L., Zeighami, Y., Hansen, J. Y., Martins, D., Zelaya, F., Dipasquale, O., Liu, T., Shin, D., Bossong, M., Azis, M., Antoniades, M., Howes, O. D., Bonoldi, I., Egerton, A., Allen, P., O'Daly, O., McGuire, P. & Modinos, G., 7 Feb 2025, (E-pub ahead of print) In: Biological psychiatry. 12 p.Research output: Contribution to journal › Article › peer-review
Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and individuals at clinical high-risk for psychosis
Knight, S., Abbasova, L., Zeighami, Y., Hansen, J., Martins, D., Zelaya, F., Dipasquale, O., Liu, T., Shin, D., Bossong, M., Azis, M., Antoniades, M., Howes, O., Bonoldi, I., Egerton, A., Allen, P., O'Daly, O., McGuire, P. & Modinos, G., 3 Feb 2025, (Accepted/In press) In: Biological psychiatry.Research output: Contribution to journal › Article › peer-review
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis
Rogdaki, M., McCutcheon, R. A., D'Ambrosio, E., Mancini, V., Watson, C. J., Fanshawe, J. B., Carr, R., Telesia, L., Martini, M. G., Philip, A., Gilbert, B. J., Salazar-de-Pablo, G., Kyriakopoulos, M., Siskind, D., Correll, C. U., Cipriani, A., Efthimiou, O., Howes, O. D. & Pillinger, T., Jul 2024, In: The Lancet Child & Adolescent Health. 8, 7, p. 510-521 12 p.Research output: Contribution to journal › Article › peer-review
Generative-Model-Based Fully 3D PET Image Reconstruction by Conditional Diffusion Sampling
Webber, G., Mizuno, Y., Howes, O., Hammers, A., King, A. & Reader, A., 25 Sept 2024, In: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD).Research output: Contribution to journal › Conference paper › peer-review
Histamine-3 Receptor Availability and Glutamate Levels in the Brain: A PET-1H-MRS Study of Patients With Schizophrenia and Healthy Controls
Arumuham, A., Nour, M. M., Veronese, M., Beck, K., Onwordi, E. C., Lythgoe, D. J., Jauhar, S., Rabiner, E. A. & Howes, O. D., 1 Mar 2024, In: International Journal of Neuropsychopharmacology. 27, 3, pyae011.Research output: Contribution to journal › Article › peer-review
Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study
Shatalina, E., Whitehurst, T. S., Onwordi, E. C., Gilbert, B. J., Rizzo, G., Whittington, A., Mansur, A., Tsukada, H., Marques, T. R., Natesan, S., Rabiner, E. A., Wall, M. B. & Howes, O. D., Dec 2024, In: EJNMMI Research. 14, 1, 41.Research output: Contribution to journal › Article › peer-review
Mortality associated with clozapine: What is the evidence?
Fernandez-Egea, E., Flanagan, R. J., Taylor, D., Gaughran, F., Lawrie, S. M., Jenkins, C., Smith, S., Howes, O. D. & MacCabe, J. H., 1 Sept 2024, In: British Journal of Psychiatry. 225, 3, p. 357-359 3 p.Research output: Contribution to journal › Editorial › peer-review
Multi-Subject Image Synthesis as a Generative Prior for Single-Subject PET Image Reconstruction
Webber, G., Mizuno, Y., Howes, O., Hammers, A., King, A. & Reader, A., 25 Sept 2024, In: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD).Research output: Contribution to journal › Conference paper › peer-review
Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis
Siafis, S., Nomura, N., Schneider-Thoma, J., Bighelli, I., Bannach-Brown, A., Ramage, F. J., Tinsdeall, F., Mantas, I., Jauhar, S., Natesan, S., Vernon, A. C., de Bartolomeis, A., Hölter, S. M., Drude, N. I., Tölch, U., Hansen, W.-P., Chiocchia, V., Howes, O. D., Priller, J. & Macleod, M. R. & 2 others, Salanti, G. & Leucht, S., 15 Jan 2024, In: F1000Research. 13, p. 1017Research output: Contribution to journal › Article › peer-review
New Drug Treatments for Schizophrenia: A Review of Approaches to Target Circuit Dysfunction
Howes, O. D., Dawkins, E., Lobo, M. C., Kaar, S. J. & Beck, K., 1 Oct 2024, In: Biological psychiatry. 96, 8, p. 638-650Research output: Contribution to journal › Article › peer-review
Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow
Sun, J., Zelaya, F., Sendt, K. V., McQueen, G., Gillespie, A. L., Lally, J., Howes, O. D., Barker, G. J., McGuire, P., MacCabe, J. H. & Egerton, A., 23 Dec 2024, In: NPJ SCHIZOPHRENIA. 10, 1, 122.Research output: Contribution to journal › Article › peer-review
Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A
Onwordi, E. C., Whitehurst, T., Shatalina, E., Mansur, A., Arumuham, A., Osugo, M., Marques, T. R., Jauhar, S., Gupta, S., Mehrotra, R., Rabiner, E. A., Gunn, R. N., Natesan, S. & Howes, O. D., 1 Apr 2024, In: Biological psychiatry. 95, 7, p. 639-646 8 p.Research output: Contribution to journal › Article › peer-review
Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis
Knight, S., Abbasova, L., Zeighami, Y., Hansen, J. Y., Martins, D., Zelaya, F., Dipasquale, O., Liu, T., Shin, D., Bossong, M., Azis, M., Antoniades, M., Howes, O., Bonoldi, I., Egerton, A., Allen, P., O'Daly, O., McGuire, P. & Modinos, G., 14 Mar 2024.Research output: Working paper/Preprint › Preprint
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Jauhar, S., Arnone, D., Baldwin, D. S., Bloomfield, M., Browning, M., Cleare, A. J., Corlett, P., Deakin, J. F. W., Erritzoe, D., Fu, C., Fusar-Poli, P., Goodwin, G. M., Hayes, J., Howard, R., Howes, O. D., Juruena, M. F., Lam, R. W., Lawrie, S. M., McAllister-Williams, H. & Marwaha, S. & 15 others, Matuskey, D., McCutcheon, R. A., Nutt, D. J., Pariante, C., Pillinger, T., Radhakrishnan, R., Rucker, J., Selvaraj, S., Stokes, P., Upthegrove, R., Yalin, N., Yatham, L., Young, A. H., Zahn, R. & Cowen, P. J., Aug 2023, In: Molecular Psychiatry. 28, 8, p. 3149-3152 4 p.Research output: Contribution to journal › Comment/debate › peer-review
Antidepressant and antipsychotic side-effects and personalised prescribing: a systematic review and digital tool development
Pillinger, T., Howes, O. D., Correll, C. U., Leucht, S., Huhn, M., Schneider-Thoma, J., Gaughran, F., Jauhar, S., McGuire, P. K., Taylor, D. M., Young, A. H. & McCutcheon, R. A., 1 Nov 2023, In: The lancet. Psychiatry. 10, 11, p. 860-876 17 p.Research output: Contribution to journal › Article › peer-review
Dopamine in major depressive disorder: A systematic review and meta-analysis of in vivo imaging studies
Mizuno, Y., Ashok, A., Bhaskar Bhat, B., Jauhar, S. & Howes, O., 23 Aug 2023, (Accepted/In press) In: Journal of Psychopharmacology.Research output: Contribution to journal › Article › peer-review
Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study
Pillinger, T., Osimo, E. F., de Marvao, A., Shah, M., Francis, C., Huang, J., D'Ambrosio, E., Firth, J., Nour, M. M., McCutcheon, R. A., Pardiñas, A. F., Matthews, P. M., O'Regan, D. P. & Howes, O. D., Feb 2023, In: The Lancet Psychiatry. 10, 2, p. 98-107 10 p.Research output: Contribution to journal › Article › peer-review
Low-frequency monitoring for community clozapine initiations: a comparative study relative to standard frequency assessments
Mizuno, Y., Butler, E., Bonoldi, I., Taylor, D. & Howes, O., 1 Apr 2023, (Accepted/In press) In: Journal of Psychopharmacology.Research output: Contribution to journal › Letter › peer-review
Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
Howes, O. D., Cummings, C., Chapman, G. E. & Shatalina, E., Jan 2023, In: Neuropsychopharmacology. 48, 1, p. 151-167 17 p.Research output: Contribution to journal › Review article › peer-review
Parsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study
Oliver, D., Davies, C., Zelaya, F., Selvaggi, P., De Micheli, A., Catalan, A., Baldwin, H., Arribas, M., Modinos, G., Crossley, N. A., Allen, P., Egerton, A., Jauhar, S., Howes, O. D., McGuire, P. & Fusar-Poli, P., 2023, In: Frontiers in Psychiatry. 14, 1092213.Research output: Contribution to journal › Article › peer-review
Schizophrenia: from neurochemistry to circuits, symptoms and treatments
Howes, O., Bukala, B. & Beck, K., 18 Dec 2023, In: Nature Reviews Neurology. 20, p. 22-35Research output: Contribution to journal › Review article › peer-review
Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A)
Onwordi, E. C., Whitehurst, T., Shatalina, E., Mansur, A., Arumuham, A., Osugo, M., Reis Marques, T., Jauhar, S., Gupta, S., Mehrotra, R., Rabiner, E. A., Gunn, R. N., Natesan, S. & Howes, O., 23 May 2023, (Accepted/In press) In: Biological psychiatry.Research output: Contribution to journal › Article › peer-review
The association between peripheral inflammation, brain glutamate and antipsychotic response in Schizophrenia: Data from the STRATA collaboration
Fenn-Moltu, S., Deakin, B., Drake, R., Howes, O. D., Lawrie, S. M., Lewis, S., Nikkheslat, N., Walters, J. T. R., MacCabe, J. H., Mondelli, V. & Egerton, A., Jul 2023, In: Brain Behavior and Immunity. 111, p. 343-351 9 p.Research output: Contribution to journal › Article › peer-review
The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia
Arumuham, A., Nour, M. M., Veronese, M., Onwordi, E. C., Rabiner, E. A. & Howes, O. D., Oct 2023, In: Journal of Psychopharmacology. 37, 10, p. 1011-1022 12 p.Research output: Contribution to journal › Article › peer-review
The Synaptic Hypothesis of Schizophrenia Version III: A Master Mechanism
Howes, O. & Onwordi, E. C., 20 Mar 2023, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Review article › peer-review
Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
Merritt, K., McCutcheon, R. A., Aleman, A., Ashley, S., Beck, K., Block, W., Bloemen, O. J. N., Borgan, F., Boules, C., Bustillo, J. R., Capizzano, A. A., Coughlin, J. M., David, A., de la Fuente-Sandoval, C., Demjaha, A., Dempster, K., Do, K. Q., Du, F., Falkai, P. & Galińska-Skok, B. & 30 others, Gallinat, J., Gasparovic, C., Ginestet, C. E., Goto, N., Graff-Guerrero, A., Ho, B.-C., Howes, O., Jauhar, S., Jeon, P., Kato, T., Kaufmann, C. A., Kegeles, L. S., Keshavan, M. S., Kim, S.-Y., King, B., Kunugi, H., Lauriello, J., León-Ortiz, P., Liemburg, E., Mcilwain, M. E., Modinos, G., Mouchlianitis, E., Nakamura, J., Nenadic, I., Öngür, D., Ota, M., Palaniyappan, L., Stone, J., McGuire, P. & Egerton, A., May 2023, In: Molecular Psychiatry. 28, 5, p. 2039-2048 10 p.Research output: Contribution to journal › Article › peer-review
What is the duration of untreated psychosis worldwide? - A meta-analysis of pooled mean and median time and regional trends and other correlates across 369 studies.
Salazar de Pablo, G., Aymerich, C., Guinart, D., Catalan, A., Alameda, L., Trotta, G., Armendariz, A., Baringo, E. M., Soler-Vidal, J., Rubio, J. M., Garrido-Torres, N., Gomez Vallejo, S., Kane, J. M., Howes, O., Fusar-Poli, P. & Correll, C. U., 18 Nov 2023, (Accepted/In press) In: Psychological medicine.Research output: Contribution to journal › Review article › peer-review
A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia
Osimo, E. F., Brugger, S. P., Thomas, E. L. & Howes, O. D., 18 Mar 2022, In: NPJ SCHIZOPHRENIA. 8, 1, 24.Research output: Contribution to journal › Article › peer-review
A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia
Correll, C. U., Agid, O., Crespo-Facorro, B., de Bartolomeis, A., Fagiolini, A., Seppälä, N. & Howes, O. D., Jul 2022, In: CNS Drugs. 36, 7, p. 659-679 21 p.Research output: Contribution to journal › Article › peer-review
A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function
D'Ambrosio, E., Pergola, G., Pardiñas, A. F., Dahoun, T., Veronese, M., Sportelli, L., Taurisano, P., Griffiths, K., Jauhar, S., Rogdaki, M., Bloomfield, M. A., Froudist-Walsh, S., Walters, J. T., Blasi, G., Bertolino, A. & Howes, O., 23 Jul 2022, In: Scientific Reports. 12, 1, 12610.Research output: Contribution to journal › Article › peer-review
Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies
Ribeiro, D., Hallett, W., Howes, O., McCutcheon, R., Nour, M. M. & Tavares, A. A. S., 20 Feb 2022, In: EJNMMI Research. 12, 1, 11.Research output: Contribution to journal › Article › peer-review
Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity
Reid, M., Rogdaki, M., Dutan Polit, L., Hanger, B., Sabad, K., Nagy, R., Adhya, D., Baron-Cohen, S., McAlonan, G., Price, J., Vernon, A., Howes, O. & Srivastava, D., 14 May 2022, (Accepted/In press) In: Schizophrenia Research.Research output: Contribution to journal › Article › peer-review
Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art
Harvey, P. D., Bosia, M., Cavallaro, R., Howes, O. D., Kahn, R. S., Leucht, S., Müller, D. R., Penadés, R. & Vita, A., Sept 2022, In: Schizophrenia Research: Cognition. 29, 100249.Research output: Contribution to journal › Article › peer-review
Cognitive function and treatment response trajectories in first-episode schizophrenia: evidence from a prospective cohort study
Millgate, E., Griffiths, K., Egerton, A., Kravariti, E., Casetta, C., Deakin, B., Drake, R., Howes, O. D., Kassoumeri, L., Khan, S., Lankshear, S., Lees, J., Lewis, S., Mikulskaya, E., Oloyede, E., Owens, R., Pollard, R., Rich, N., Smart, S. & Segev, A. & 2 others, Verena Sendt, K. & MacCabe, J., 21 Nov 2022, In: BMJ Open. 12, 11, e062570.Research output: Contribution to journal › Article › peer-review
Dopamine partial agonists and prodopaminergic drugs for schizophrenia: Systematic review and meta-analysis of randomized controlled trials
Osugo, M., Whitehurst, T., Shatalina, E., Townsend, L., O'Brien, O., Mak, T. L. A., McCutcheon, R. & Howes, O., 30 Apr 2022, In: Neuroscience and Biobehavioral Reviews. 135, 104568.Research output: Contribution to journal › Review article › peer-review
Efficacy and safety of Lu AF35700 in treatment-resistant schizophrenia: A randomized, active-controlled trial with open-label extension
the DayBreak and Debut study investigators, 1 Oct 2022, In: Schizophrenia Research. 248, p. 271-278 8 p.Research output: Contribution to journal › Article › peer-review
Emerging Treatments in Schizophrenia
Correll, C. U., Abi-Dargham, A. & Howes, O., Jan 2022, In: Journal of Clinical Psychiatry. 83, 1, SU21024IP1.Research output: Contribution to journal › Article › peer-review
Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
Halff, E. F., Natesan, S., Bonsall, D. R., Veronese, M., Garcia-Hidalgo, A., Kokkinou, M., Tang, S. P., Riggall, L. J., Gunn, R. N., Irvine, E. E., Withers, D. J., Wells, L. A. & Howes, O. D., 2022, In: Molecular Imaging. 2022, 4419221.Research output: Contribution to journal › Article › peer-review
Evaluation of intraperitoneal [18F]-FDOPA administration for micro-PET imaging in mice and assessment of the effect of sub-chronic ketamine dosing on dopamine synthesis capacity
Halff, E., Natesan, S., Bonsall, D. R., Veronese, M., Garcia-Hidalgo, A., Kokkinou, M., Tang, S.-P., Riggall , L., Gunn, R., Irvine, E., Withers, D., Wells, L. & Howes, O., 8 Oct 2022, (Accepted/In press) In: Molecular Imaging. 4419221.Research output: Contribution to journal › Article › peer-review
Impaired verbal memory function is related to anterior cingulate glutamate levels in schizophrenia: findings from the STRATA study
Griffiths, K., Egerton, A., Millgate, E., Anton, A., Barker, G. J., Deakin, B., Drake, R., Eliasson, E., Gregory, C. J., Howes, O. D., Kravariti, E., Lawrie, S. M., Lewis, S., Lythgoe, D. J., Murphy, A., McGuire, P., Semple, S., Stockton-Powdrell, C., Walters, J. T. R. & Williams, S. R. & 1 others, MacCabe, J. H., 12 Jul 2022, In: Schizophrenia. 8, 1, p. 60 60.Research output: Contribution to journal › Article › peer-review
Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance
Howes, O. D. & Shatalina, E., 15 Sept 2022, In: Biological psychiatry. 92, 6, p. 501-513 13 p.Research output: Contribution to journal › Review article › peer-review
Low COVID-19 vaccination rates in people with severe mental illness and reasons for this: An out-patient study
Arumuham, A., O’Brien, O., Ahmad, Z., Nikbin, K. & Howes, O. D., Apr 2022, In: Acta Psychiatrica Scandinavica. 145, 4, p. 416-418 3 p.Research output: Contribution to journal › Article › peer-review
New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics
Lobo, M. C., Whitehurst, T. S., Kaar, S. J. & Howes, O. D., Jan 2022, In: Neuroscience and Biobehavioral Reviews. 132, p. 324-361 38 p.Research output: Contribution to journal › Review article › peer-review
Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis
PRONIA Consortium, Howes, O. & Koutsouleris, N., 9 Mar 2022, In: Schizophrenia. 8, 1, p. 19Research output: Contribution to journal › Article › peer-review
Real-world clinical and cost-effectiveness of community clozapine initiation: mirror cohort study
Butler, E., Pillinger, T., Brown, K., Borgan, F., Bowen, A., Beck, K., D'Ambrosio, E., Jauhar, S., Kaar, S., McCutcheon, R., Rogdaki, M., Gaughran, F., Maccabe, J., Ramsay, R., McCrone, P., Egerton, A. & Howes, O., 11 Dec 2022, In: British Journal of Psychiatry. 221, 6, p. 740-747 8 p.Research output: Contribution to journal › Article › peer-review
Research

STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances
People with schizophrenia suffer from a range of symptoms including hallucinations (such as hearing voices), delusions (false beliefs) and thought disorder (thoughts not flowing in a logical way).

UNIQUE Research Group
UNIQUE Research group carries out a range of sudies involving people who experience persistent, full-blown psychotic experiences but are not in need of care

ATLANTIS - AnTiconvuLsant AugmeNtation Trial In Schizophrenia
NIHR funded multi-centre clinical trial evaluating valproate augmentation of antipsychotic medication in the management of psychosis
News
Obesity drugs found to improve emotional wellbeing as well as physical health
A major new meta-analysis from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that glucagon-like peptide 1...

Professors Oliver Howes and Marta Di Forti presented with Schizophrenia Research Society Outstanding Translational Research Awards
Professor Howes and Professor Di Forti were presented their awards on 29 March 2025 at the 2025 Congress of the Schizophrenia International Research Society...

Researchers receive £4.1million to research new modelling and treatment approaches for auditory hallucinations in people with psychosis
The Wellcome Trust Mental Health Award will fund testing of a computational model of the role of cortical circuits in understanding auditory hallucinations...

New tool to streamline prescribing of antidepressants
A new web tool has been designed by researchers at King's College London and the University of Oxfordto simplify the prescription of antidepressant and...

'When the drugs don't work: the challenge of treatment resistant psychosis'
Professor James MacCabe delivered the ninth inaugural lecture of the 2022/23 IoPPN Inaugural Lecture Series, entitled 'When the drugs don’t work: the...

Oliver Howes receives the ACNP Joel Elkes Research Award
The American College of Neuropsychopharmacology (ACNP) has named Professor Oliver Howes as the recipient of the 2022 Joel Elkes Research Award.

Two IoPPN Professors elected as new Fellows of the Academy of Medical Sciences
Professor Oscar Marín and Professor Oliver Howes from the Institute of Psychiatry, Psychology & Neuroscience at King’s have been elected to the prestigious...

Events

Dr Paul Janssen Lecture: Neuroinflammation and psychosis: a new dawn or bleak midwinter?
A Dr Paul Janssen lecture with Rachel Upthegrove MBE, Professor of Psychiatry in the Department of Psychiatry, University of Oxford.
Please note: this event has passed.

Unveil Psychosis Heterogeneity: Stratification via Circuit-Based Biomarkers
A Paul Janssen lecture with Professor Kim Q. Do, Professor of Translational Psychiatry at Lausanne University, Switzerland.
Please note: this event has passed.

Professor James MacCabe - Inaugural Lecture
Join us in celebrating Professor James MacCabe's inaugural lecture on 'When the drugs don't work: the challenge of treatment resistant psychosis'
Please note: this event has passed.
Features
IoPPN Inaugural Lectures: 2017-2019
Inaugural lectures are given by newly arrived or promoted professors, who use the opportunity to introduce themselves, to present an overview of their own...
