My lab is interested in the enzymes that synthesis 2-AG, the major endocannabinoid in the body. We have provided genetic evidence for 2-AG regulating adult neurogenesis in the hippocampus and subventricular zone, and demonstrated that drugs that promote eCB signalling can prevent the normal age-related dramatic decline in neurogenesis. The current recent focus of the lab is on the development of neurotrophin receptor agonist antibodies that can cross the blood brain barrier to promote neuronal survival in neurodegenerative disease states.
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