Professor Phillip Gordon-Weeks PhD

Biography

I am interested in how neurons in the embryonic brain connect with each other to form neuronal circuits. A fundamental molecular mechanism is the action of homing signals that guide neuronal migration and axon and dendrite growth. These signals influence the behaviour of the cytoskeleton within neurons. How this is achieved is a central area of research and has relevance to other examples of cellular migration such as cancer cell metastasis.

Please see my Research Staff Profile for more detail.

Key Publications:

• Trivedi et al., 2017. Drebrin mediated microtubule-actomyosin coupling steers two-stroke nucleokinesis and migration pathway selection in cerebellar granule neurons. Nature Communications.
• Dart, et al., 2017. The drebrin/EB3 pathway drives invasive activity in prostate cancer. Oncogene.
• Geraldo, et al., 2008. Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis. Nature Cell Biology.