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Rob Jefferson

Robert Jefferson

Lecturer in Chemistry


Dr Robert Jefferson is a Lecturer in the Department of Chemistry, King’s College London. He received his BA in Biochemistry, Biophysics, & Molecular Biology from Whitman College and his PhD in Biochemistry & Molecular Biology from UCLA in the laboratory of James Bowie developing techniques for studying membrane protein folding under native conditions with funding from an NIH Training Fellowship in Cellular & Molecular Biology. He then applied his knowledge of physical biochemistry to the computational design of GPCRs for cellular engineering in the laboratory of Patrick Barth at EPFL under a Marie Skłodowska-Curie Postdoctoral Fellowship. In 2023, Robert moved to the Department of Chemistry, King’s College London, to establish his group as a Lecturer in Chemistry. His research applies both computational and experimental techniques to modelling and design of dynamic membrane protein complexes for cellular engineering. The work seeks to understand the underlying molecular mechanisms of protein stability and function, as well as developing new protein-based therapeutic and synthetic biology tools.

Research Interests

  • Engineering membrane protein quaternary stability
  • Molecular determinants of peptide-activated GPCRs
  • Computational design of intracellular signaling scaffold complexes

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