I am a Postdoctoral Research Associate in Dr. Ciro Chiappini Lab at King’s College London, UK. I did my PhD from UNESCO-Regional Centre for Biotechnology, India and worked on investigating the role of PTM’s like SUMOylation in intestinal mucosal biology. My work was particularly focused on understanding the involvement of SUMO enzymes in controlling intestinal infections and inflammation associated disorders. I have gained extensive research experience in molecular biology, cellular biology, immunology and gene therapy. Our group identified the involvement of SUMO enzyme Ubc9 and PIAS1 in IBD pathogenesis and Salmonella induced gut infection. In line with this we developed nanogel based gene delivery method for colitis treatment in-vivo. I have published peer-reviewed research articles in Nanoscale, Royal Society of Open Biology and Molecular and Cellular Biology. Post PhD, I have worked as a Postdoctoral Research Associate at Yale University, School of Medicine for 1 year. My work was focused on investigating the role of autophagy in mucosal biology.
At King’s College London, my work involves in-vitro characterisation and optimisation of nanoneedle mediated delivery of COL7A1 gene in skin fibroblasts, keratinocytes and organoids for treating recessive dystrophic epidermolysis bullosa (RDEB). Main aim of this project is to develop a rapid, minimally invasive and novel method for treating rare and non-curable disease like RDEB.