Simon Cleary PhD Academics Lecturer in Pharmacology Contact details simon.cleary@kcl.ac.uk Simon Cleary
Collecting lymphatics unzip to drain injured lungs Decoding functional hematopoietic progenitor cells in the adult human lung Imaging lung lymphatics in action in metastatic cancer Impact of chronic hyperglycaemia on the coronary microcirculation - benefits of targeting IL-36 and diet reversal Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer Spleen tyrosine kinase inhibition mitigates hemin-induced thromboinflammation in an organ-specific manner in sickle cell mice CD94 + natural killer cells potentiate pulmonary ischaemia-reperfusion injury Decoding functional hematopoietic progenitor cells in the adult human lung IgG hexamers initiate acute lung injury IgG hexamers initiate complement-dependent acute lung injury Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens In Vivo Using Positron Emission Tomography Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury Reply: The importance of disrupting complement activation in acute lung injury Tnik: A redox sensor in endothelial cell permeability CCR5 drives NK cell–associated airway damage in pulmonary ischemia-reperfusion injury Imaging inflammation Investigating and imaging platelets in inflammation Optimizing anesthesia and delivery approaches for dosing into lungs of mice Optimizing anesthesia and delivery approaches for dosing into lungs of mice ADAM8 signaling drives neutrophil migration and ARDS severity Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression Chewing the fat on TRALI Global absence and targeting of protective immune states in severe COVID-19 In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET Lung megakaryocytes are immune modulatory cells Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3 Red Blood Cells Elicit Platelet-Dependent Neutrophil Recruitment Into Lung Airspaces The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection β2m signals monocytes through non-canonical tgfβ receptor signal transduction Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology Complement activation on endothelium initiates antibody-mediated acute lung injury Global Absence and Targeting of Protective Immune States in Severe COVID-19 Mitochondrial DNA stimulates TLR9-dependent neutrophil extracellular trap formation in primary graft dysfunction Radiolabelling and immunohistochemistry reveal platelet recruitment into lungs and platelet migration into airspaces following LPS inhalation in mice Update on animal models for COVID-19 research LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin Pharmacological strategies for targeting platelet activation in asthma Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis Gustav Born: pioneer in imaging platelet and leukocyte biology Platelet depletion impairs host defence to pulmonary infection with Pseudomonas aeruginosa in mice Platelets Play a Central Role in Sensitization to Allergen Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice The application of local hypobaric pressure - A novel means to enhance macromolecule entry into the skin Exploring dual PDE3/4 inhibition in the treatment of airway diseases P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation View all publications