Dr Tibor Hortobagyi Academics Supervisors Reader in Old Age Psychiatry Research subject areas Ageing Psychiatry Contact details tibor.hortobagyi@kcl.ac.uk
Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis Neuropathological links between T2DM and LOAD: systematic review and meta-analysis Comparison of semi-quantitative scoring and artificial intelligence aided digital image analysis of chromogenic immunohistochemistry Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging Structural synaptic signatures of Alzheimer's disease and dementia with Lewy bodies in the male brain The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro Extracellular matrix changes in corneal opacification vary depending on etiology Karyopherin abnormalities in neurodegenerative proteinopathies Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study Salivary osteopontin as a potential biomarker for oral mucositis Small vessels in the brain and heart: How similar are they? An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders Pathological and clinical comparison of Parkinson's disease dementia and dementia with Lewy bodies Dementia with Lewy bodies – a clinicopathological update Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-Tau in neuropathological stages of alzheimer’s disease Microglia monitor and protect neuronal function through specialized somatic purinergic junctions Neuropsychiatric symptoms, quality of life and caregivers' burden in dementia N-glycosylation alteration of serum and salivary immunoglobulin a is a possible biomarker in oral mucositis Advanced cerebral amyloid angiopathy and small vessel disease are associated with psychosis in Alzheimer's disease Behavioural and psychological symptoms in neurocognitive disorders: Specific patterns in dementia subtypes Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2) is a component of TDP-43 aggregates specifically in the A and C pathological subtypes of frontotemporal lobar degeneration. Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration Molecular mechanisms of neurodegeneration related to C9orf72 hexanucleotide repeat expansion Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer’s disease and neocortical Lewy body disease Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease Serum Potassium Is Associated with Cognitive Decline in Patients with Lewy Body Dementia Tyrosine Kinase Inhibitor Imatinib Mesylate Alters DMBA-Induced Early Onco/Suppressor Gene Expression with Tissue-Specificity in Mice A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration Biological function of Lemur tyrosine kinase 2 (LMTK2): Implications in neurodegeneration Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach The melanin-concentrating hormone system in human, rodent and avian brain Accuracy of Clinical Diagnosis of Dementia with Lewy Bodies versus Neuropathology A novel point mutation affecting asn76 of dystrophin protein leads to dystrophinopathy CLINICO-PATHOLOGIC ASSOCIATIONS IN DLB: RELEVANCE FOR DIAGNOSIS AND TREATMENT: 2017 Abstract Supplement Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia RELATIONSHIP BETWEEN PATHOLOGY SCORES, CLINICAL DATA AND EXPRESSION LEVELS OF PROTEASOME SUB-UNITS IN ALZHEIMER’S DISEASE AND LEWY BODY DEMENTIAS: 2017 Abstract Supplement Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss Cognitive decline in dementia with Lewy bodies: a 5-year prospective cohort study Lack of association between TDP-43 pathology and tau mis-splicing in Alzheimer's disease Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease Gamma-synuclein pathology in amyotrophic lateral sclerosis Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium Regional Multiple Pathology Scores are Associated with Cognitive Decline in Lewy Body Dementias Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS View all publications