Professor Valeria Mondelli Academics Clinical Professor of Psychoneuroimmunology Research subject areas Mental Health Contact details @MondelliValeria 02078480353 valeria.mondelli@kcl.ac.uk
A Pilot Study of the Real-World Impact of Digital Cognitive Behavioral Therapy for Inflammatory Bowel Disease (COMPASS-IBD) on Inflammation, Disease Activity, and Healthcare Use Transcriptomic activation of immune cell trafficking predicts antidepressant response to minocycline Protocol to develop and pilot a primary mental healthcare intervention model to address the medium- to long-term Ebola associated psychological distress and psychosocial problems in Mubende District in Central Uganda (the Ebola+D project) Peripheral blood transcriptomic differences predict depression status in individuals undergoing bariatric surgery First-person pronouns as linguistic markers of depression among Brazilian youths A novel blood-free analytical framework for the quantification of neuroinflammatory load from TSPO PET Imaging Autism, ADHD, and Their Traits in Adults with Obesity: A Scoping Review Autism, ADHD, and Their Traits in Adults With Bulimia Nervosa and Binge Eating Disorder: A Scoping Review The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage. Advancing precision psychiatry and targeted treatments: Insights from immunopsychiatry Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis Barriers and facilitators to identifying depression in adolescents: a cross-cultural qualitative study in Brazil, Nepal, and Nigeria Methylomic signature of current cannabis use in two first-episode psychosis cohorts Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation Sex-Specific Alterations of the Kynurenine Pathway in Association with Risk for and Remission of Depression in Adolescence No prediction without prevention: A global qualitative study of attitudes toward using a prediction tool for risk of developing depression during adolescence Extra-axial inflammatory signal and its relation to peripheral and central immunity in depression Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging Exploring the research needs, barriers and facilitators to the collection of biological data in adolescence for mental health research: a scoping review protocol paper Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression Biomarkers Associated with Treatment Outcome in Young People with Depression: A Systematic Review Disturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation Autism and ADHD in adult patients with Bulimia Nervosa, Binge Eating Disorder, and/or Obesity: a scoping review protocol MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume Inflammation and immune system pathways as biological signatures of adolescent depression – the IDEA-RiSCo study Childhood trauma associated with increased post-awakening cortisol in major depressive disorder Do interventions for mood improve inflammatory biomarkers in inflammatory bowel disease? a systematic review and meta-analysis The bio-exposome: intracellular processes, stress physiology and the environment Prospective Follow-up of Adolescents with and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo) Longitudinal Assessments The stress axis: neuroendocrine-immune-metabolic regulation and its role in the development of metabolic syndrome and depression A collaborative realist review of remote measurement technologies for depression in young people Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study Heart Rate Variability (HRV) as a way to Understand Associations between theAutonomic Nervous System (ANS) and Affective States: A Critical Review of the Literature Peripheral inflammation associated with depression and reduced weight loss: a longitudinal study of bariatric patients Sex-specific inflammatory markers of risk and presence of depression in adolescents The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression The association between peripheral inflammation, brain glutamate and antipsychotic response in Schizophrenia: Data from the STRATA collaboration The interaction between kynurenine pathway, suicidal ideation, and augmentation therapy with minocycline in patients with treatment-resistant depression The Identifying Depression Early in Adolescence Chatbot (IDEABot): Protocol for development and implementation of a frugal innovation tool for mood assessment Sickness Behaviour and Depression: An Updated Model of Peripheral-Central Immunity Interactions Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response A magnetic resonance imaging-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample Serum Immune Markers and Transition to Psychosis in Individuals at Clinical High Risk Gone Too Soon: priorities for action to prevent premature mortality associated with mental illness and mental distress Efficacy of low carbohydrate and ketogenic diets in treating mood and anxiety disorders: systematic review and implications for clinical practice Childhood trauma associated with increased post-awakening cortisol in major depressive disorder Self-Reported Social Media Use by Adolescents in Brazil: A School-Based Survey Identifying adolescents at risk for depression: assessment of a global prediction model in the Great Smoky Mountains Study View all publications
25 March 2025 Biological pathway in the brain could help explain why teenage girls are more depressed than boys New research from the IoPPN has shown that a biological brain mechanism called the ‘kynurenine…