Agromayor Group

The Agromayor laboratory uses a multidisciplinary approach involving the latest imaging, biochemical and genetic techniques to study how cells reorganise their cytoskeleton and plasma membrane during infection and cell division.

During the last few years, our research has focused on how viruses manipulate and exploit the endosomal sorting complex required for transport (ESCRT) machinery to promote their replication. Our work in this area has revealed a mechanism to functionally tailor the ESCRTs for different cellular processes by binding differentially to components of the machinery depending on the required activity. This way, the same cellular machinery can catalyse the scission of thin membranous stalks present in the final stages of topologically equivalent membrane remodelling processes such as enveloped virus budding, endosomal sorting of ubiquitinated membrane cargo and cytokinesis.

Current PhD students
Samuel Wallis
Evita Otigbah

Members

Monica Agromayor

Lecturer

Our research

Currently, our research is focused on investigating the mechanisms by which mammalian cells orchestrate the cytoskeletal and membrane remodelling processes occurring during cytokinesis and viral infection.

ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins 26 May 2015

An ESCRT module is required for neuron pruning 13 February 2015

Knowing when to cut and run: mechanisms that control cytokinetic abscission 01 September 2013

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes 23 October 2012

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C 13 April 2012

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain 07 March 2012

Essential Role of hIST1 in Cytokinesis 01 March 2009

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release 29 July 2008

Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo 11 August 2006

Molecular epidemiology of molluscum contagiosum virus and analysis of the host-serum antibody response in Spanish HIV-negative patients 01 February 2002

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