Agromayor Group

The Agromayor laboratory uses a multidisciplinary approach involving the latest imaging, biochemical and genetic techniques to study how cells reorganise their cytoskeleton and plasma membrane during infection and cell division.

During the last few years, our research has focused on how viruses manipulate and exploit the endosomal sorting complex required for transport (ESCRT) machinery to promote their replication. Our work in this area has revealed a mechanism to functionally tailor the ESCRTs for different cellular processes by binding differentially to components of the machinery depending on the required activity. This way, the same cellular machinery can catalyse the scission of thin membranous stalks present in the final stages of topologically equivalent membrane remodelling processes such as enveloped virus budding, endosomal sorting of ubiquitinated membrane cargo and cytokinesis.

Current PhD students
Samuel Wallis
Evita Otigbah

Members

Monica Agromayor

Lecturer

Our research

Currently, our research is focused on investigating the mechanisms by which mammalian cells orchestrate the cytoskeletal and membrane remodelling processes occurring during cytokinesis and viral infection.

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair
Wallis, S. S., Ventimiglia, L. N., Otigbah, E., Infante, E., Cuesta-Geijo, M. A., Kidiyoor, G. R., Carbajal, M. A., Fleck, R. A., Foiani, M., Garcia-Manyes, S., Martin-Serrano, J. & Agromayor, M., 6 Dec 2021, In: Developmental Cell. 56, 23, p. 3192-3202.e8 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.devcel.2021.10.022
Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
Lista, M. J., Matos, P. M., Maguire, T. J. A., Poulton, K., Ortiz-Zapater, E., Page, R., Sertkaya, H., Ortega-Prieto, A. M., Scourfield, E., O'Byrne, A. M., Bouton, C., Dickenson, R. E., Ficarelli, M., Jimenez-Guardeño, J. M., Howard, M., Betancor, G., Galao, R. P., Pickering, S., Signell, A. W., Wilson, H. & 17 others, Cliff, P., Kia Ik, M. T., Patel, A., MacMahon, E., Cunningham, E., Doores, K., Agromayor, M., Martin-Serrano, J., Perucha, E., Mischo, H. E., Shankar-Hari, M., Batra, R., Edgeworth, J., Zuckerman, M., Malim, M. H., Neil, S. & Martinez-Nunez, R. T., 15 Sep 2021, In: PLoS ONE. 16, 9 September, e0256813. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0256813
Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
Lista, M. J., Matos, P. M., Maguire, T. J. A., Poulton, K., Ortiz-Zapater, E., Page, R., Sertkaya, H., Ortega-Prieto, A. M., O'Byrne, A. M., Bouton, C., Dickenson, R. E., Ficarelli, M., Jimenez-Guardeño, J. M., Howard, M., Betancor, G., Galao, R. P., Pickering, S., Signell, A. W., Wilson, H., Cliff, P. & 16 others, Ik, M. T. K., Patel, A., MacMahon, E., Cunningham, E., Doores, K., Agromayor, M., Martin-Serrano, J., Perucha, E., Mischo, H. E., Shankar-Hari, M., Batra, R., Edgeworth, J., Zuckerman, M., Malim, M. H., Neil, S. & Martinez-Nunez, R. T., 10 Apr 2021, (MedRxiv). Research output: Working paper/Preprint › Preprint. DOIs: https://doi.org/10.1101/2020.04.22.20074351
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
Caballe, A., Wenzel, D. M., Agromayor, M., Alam, S. L., Skalicky, J. J., Kloc, M., Carlton, J. G., Labrador, L., Sundquist, W. I. & Martin-Serrano, J., 26 May 2015, In: eLife. 4, 0, 36 p., e06547. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.7554/eLife.06547
An ESCRT module is required for neuron pruning
Loncle, N., Agromayor, M., Martin-Serrano, J. & Williams, D. W., 13 Feb 2015, In: Scientific Reports. 5, 1, 11 p., 8461. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/srep08461
Knowing when to cut and run: mechanisms that control cytokinetic abscission
Agromayor, M. & Martin-Serrano, J., Sep 2013, In: Trends in cell biology. 23, 9, p. 433-441 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.tcb.2013.04.006
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes
Hadders, M. A., Agromayor, M., Obita, T., Perisic, O., Caballe, A., Kloc, M., Lamers, M. H., Williams, R. L. & Martin Serrano, J., 23 Oct 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17424-17429 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1073/pnas.1206839109
ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C
Carlton, J. G., Caballe, A., Agromayor, M., Kloc, M. & Martin-Serrano, J., 13 Apr 2012, In: Science. 336, 6078, p. 220 - 225 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/science.1217180
The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain
Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S. M., Allen, M. D., Bycroft, M., Perisic, O., Ye, Y., McDonald, B., Scheel, H., Hofmann, K., Neil, S. J. D., Martin-Serrano, J. & Williams, R. L., 7 Mar 2012, In: Structure. 20, 3, p. 414 - 428 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.str.2011.12.013
Essential Role of hIST1 in Cytokinesis
Agromayor, M., Carlton, J. G., Phelan, J. P., Matthews, D. R., Carlin, L. M., Ameer-Beg, S., Bowers, K. & Martin-Serrano, J., 1 Mar 2009, In: Molecular Biology of the Cell. 20, 5, p. 1374 - 1387 14 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1091/mbc.E08-05-0474

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Outreach

Dr Agromayor is an In2scienceUK ambassador and runs the School of Immunology & Microbial Sciences Summer School

In2science UK

Carmen Bugarin Diz (MRes student 2015-2016,research assistant 2016-2017)

Nawal Maïssa (post-doc 2016-2019)

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Biotechnology & Biological Sciences Research Council

Agromayor Group

Members

Monica Agromayor

Our research

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation

Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation

ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

An ESCRT module is required for neuron pruning

Knowing when to cut and run: mechanisms that control cytokinetic abscission

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain

Essential Role of hIST1 in Cytokinesis

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