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The Agromayor laboratory uses a multidisciplinary approach involving the latest imaging, biochemical and genetic techniques to study how cells reorganise their cytoskeleton and plasma membrane during infection and cell division.

During the last few years, our research has focused on how viruses manipulate and exploit the endosomal sorting complex required for transport (ESCRT) machinery to promote their replication. Our work in this area has revealed a mechanism to functionally tailor the ESCRTs for different cellular processes by binding differentially to components of the machinery depending on the required activity. This way, the same cellular machinery can catalyse the scission of thin membranous stalks present in the final stages of topologically equivalent membrane remodelling processes such as enveloped virus budding, endosomal sorting of ubiquitinated membrane cargo and cytokinesis.

Themes

reaseach
Our research

Currently, our research is focused on investigating the mechanisms by which mammalian cells orchestrate the cytoskeletal and membrane remodelling processes occurring during cytokinesis and viral infection.

    Publications

      Activities

      outreach
      Outreach

      Dr Agromayor is an In2scienceUK ambassador and runs the School of Immunology & Microbial Sciences Summer School

      Previous lab members

      • Carmen Bugarin Diz (MRes student 2015-2016, research assistant 2016-2017)
      • Nawal Maïssa (post-doc 2016-2019)
      • Samuel Wallis (PhD student 2016-2021)
      • Evita Otigbah (PhD student 2017-2022)

      Themes

      reaseach
      Our research

      Currently, our research is focused on investigating the mechanisms by which mammalian cells orchestrate the cytoskeletal and membrane remodelling processes occurring during cytokinesis and viral infection.

        Publications

          Activities

          outreach
          Outreach

          Dr Agromayor is an In2scienceUK ambassador and runs the School of Immunology & Microbial Sciences Summer School

          Previous lab members

          • Carmen Bugarin Diz (MRes student 2015-2016, research assistant 2016-2017)
          • Nawal Maïssa (post-doc 2016-2019)
          • Samuel Wallis (PhD student 2016-2021)
          • Evita Otigbah (PhD student 2017-2022)

          Our Partners

          BBSRC

          Biotechnology & Biological Sciences Research Council