Mechanisms of kinesin management by kinesin binding protein
Kinesin-binding protein (KBP) associates with a subset of kinesin family motor domains, inhibiting microtubule attachment. KBP is important in a number of cellular processes including mitosis, spermatogenesis and neuronal differentiation and cargo distribution. The KBP gene causes a developmental condition known as Goldberg-Shprintzen syndrome and certain genotypes drive neuroblastoma survival outcomes. We study the structural mechanisms of KBP’s kinesin member selection and inhibition, as well the regulation and function of KBP in cellular processes, using cryo-electron microscopy and supporting techniques.