Our Group is led by Professor Patricia Barral. We are interested in understanding the cellular mechanisms that initiate and shape immunity in the tissues, particularly focussing on the biology and function of unconventional T cells (NKT cells, MAIT cells) in the context of infection, inflammation and cancer.
People
PhD Student
Professor of Immunobiology
PhD Student
Postdoctoral Research Associate
Projects
Immunity in the intestine
We are investigating the mechanisms that regulate unconventional T cell functions in intestinal immunity. Through this work we have identified the cellular crosstalk controlling the activation of lipid-reactive NKT cells and explored the mechanisms by which NKT cells modulate intestinal epithelial cell fate and contribute to the establishment of intestinal homeostasis. We are currently investigating novel mechanisms by which NKT cells regulate epithelial regeneration in the context of intestinal inflammation.
Metabolic regulation of Immunity in cancer
While lipids have been traditionally regarded as quiescent components of cell membranes, in recent years it has become clear that lipid metabolism and the cellular lipid status play central roles in the regulation of immune cell activation and function. Our lab has recently identified a novel mechanistic link between innate immunity and cellular lipid metabolism. We are now exploring the mechanisms by which tissue derived signals control the immune lipidome, and how this in turn regulates immune cell activation and the outcome of immune responses particularly in the context of cancer.
Immunity in the skin
The skin is a complex immunological niche containing high numbers of immune cells that regulate skin homeostasis and protect from external insults. Unconventional T cells are present in the skin where they play a central role in the pathogenesis of skin diseases including psoriasis and atopic dermatitis. We aim to address how the interplay between unconventional T cell and the skin microbiome regulates skin health.
Publications
The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses
He, C., Wang, S., Moreews, M., Pei, S., Chen, G., Li, Q.-Z., Del Monte Monge, A., Ramiro, A., Cai, C., Gaya, M., Barral, P., Buggert, M., Batista, F. & Karlsson, M., 27 May 2025, In: Cell Reports. 44, 5, 115602.Research output: Contribution to journal › Article › peer-review
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
Acha-Sagredo, A., Andrei, P., Clayton, K., Taggart, E., Antoniotti, C., Woodman, C. A., Afrache, H., Fourny, C., Armero, M., Moinudeen, H. K., Green, M., Bhardwaj, N., Mikolajczak, A., Rodriguez-Lopez, M., Crawford, M., Connick, E., Lim, S., Hobson, P., Linares, J. & Ignatova, E. & 17 others, Pelka, D., Smyth, E. C., Diamantis, N., Sosnowska, D., Carullo, M., Ciraci, P., Bergamo, F., Intini, R., Nye, E., Barral, P., Mishto, M., Arnold, J. N., Lonardi, S., Cremolini, C., Fontana, E., Rodriguez-Justo, M. & Ciccarelli, F. D., 10 Feb 2025, In: CANCER CELL. 43, 2, p. 292-307.e7Research output: Contribution to journal › Article › peer-review
Mucosal associated invariant T cells: Powerhouses of the lung
Lopez Rodriguez, J. & Barral, P., Oct 2024, In: Immunology Letters. 269, 106910.Research output: Contribution to journal › Review article › peer-review
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
Lebrusant-Fernandez, M., Ap Rees, T., Jimeno, R., Angelis, N., Ng, J. C., Fraternali, F., Li, V. S. W. & Barral, P., Dec 2024, In: Cell Reports. 43, 12, p. 114948 114948.Research output: Contribution to journal › Article › peer-review
CD1 MOLECULES: BEYOND ANTIGEN PRESENTATION
Evans, L. & Barral, P., 2024, In: Molecular Immunology.Research output: Contribution to journal › Review article › peer-review
Type I interferons drive MAIT cell functions against bacterial pneumonia
Lopez Rodriguez, J., Hancock, S., Li, K., Crotta, S., Barrington, C., Suarez-Bonnet, A., Priestnall, S., Aube, J., Wack, A., Klenerman, P., Bengoechea, J. & Barral, P., 2 Oct 2023, In: The Journal of experimental medicine. 220, 10, e20230037.Research output: Contribution to journal › Article › peer-review
CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses
Brailey, P. M., Evans, L., Lopez-Rodriguez, J. C., Sinadinos, A., Tyrrel, V., Kelly, G., O’Donnell, V., Ghazal, P., John, S. & Barral, P., 7 Nov 2022, In: Nature Communications. 13, 1, 6723.Research output: Contribution to journal › Article › peer-review
NKT cells and the regulation of intestinal immunity: A two-way street.
Brailey, P. M., Lebrusant Fernandez, M. & Barral, P., 1 May 2020, In: FEBS Journal. 287, 9, p. 1686-1699 14 p.Research output: Contribution to journal › Review article › peer-review
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
Jimeno , R., Lebrusant-Fernandez, M., Margreitter, C., Lucas, B., Veerapen, N., Besra, G., Fraternali, F., Spencer, J., Anderson, G. & Barral, P., 24 Dec 2019, In: eLife. 8, e51663.Research output: Contribution to journal › Article › peer-review
Quantitative polymerase chain reaction-based analyses of murine intestinal microbiota after oral antibiotic treatment
Jimeno, R., Brailey, P. M. & Barral, P., 17 Nov 2018, In: Journal of Visualized Experiments. 2018, 141, e58481.Research output: Contribution to journal › Article › peer-review
qPCR-BASED ANALYSES OF INTESTINAL MICROBIOTA AFTER ORAL ANTIBIOTIC TREATMENT OF MICE
Jimeno , R., Brailey, P. M. & Barral , P., 2018, In: Journal of Visualized Experiments.Research output: Contribution to journal › Article › peer-review
CD1d-mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis
Sáez de Guinoa, J., Jimeno, R., Gaya, M., Kipling, D., Garzón, M. J., Dunn-Walters, D., Ubeda, C. & Barral, P., 1 Mar 2018, In: EMBO Journal. 37, 5, 17 p., e97537.Research output: Contribution to journal › Article › peer-review
NMR solution structure of Ole e 6, a major allergen from olive tree pollen
Treviño, M. A., García-Mayoral, M. F., Barral, P., Villalba, M., Santoro, J., Rico, M., Rodríguez, R. & Bruix, M., 10 Sept 2004, In: Journal of Biological Chemistry. 279, 37, p. 39035-41 7 p.Research output: Contribution to journal › Article › peer-review
Recombinant expression of Ole e 6, a Cys-enriched pollen allergen, in Pichia pastoris yeast: detection of partial oxidation of methionine by NMR
Barral, P., Tejera, M. L., Treviño, M. A., Batanero, E., Villalba, M., Bruix, M. & Rodríguez, R., Oct 2004, In: Protein expression and purification. 37, 2, p. 336-43 8 p.Research output: Contribution to journal › Article › peer-review
A major allergen from pollen defines a novel family of plant proteins and shows intra- and interspecies [correction of interspecie] cross-reactivity
Barral, P., Batanero, E., Palomares, O., Quiralte, J., Villalba, M. & Rodríguez, R., 15 Mar 2004, In: Journal of Immunology. 172, 6, p. 3644-51 8 p.Research output: Contribution to journal › Article › peer-review
An olive pollen protein with allergenic activity, Ole e 10, defines a novel family of carbohydrate-binding modules and is potentially implicated in pollen germination
Barral, P., Suárez, C., Batanero, E., Alfonso, C., Alché, J. D. D., Rodríguez-García, M. I., Villalba, M., Rivas, G. & Rodríguez, R., 15 Aug 2005, In: Biochemical Journal. 390, Pt 1, p. 77-84 8 p.Research output: Contribution to journal › Article › peer-review
Encapsulation of Ole e 1 in biodegradable microparticles induces Th1 response in mice: a potential vaccine for allergy
Batanero, E., Barral, P., Villalba, M. & Rodríguez, R., 30 Oct 2003, In: JOURNAL OF CONTROLLED RELEASE. 92, 3, p. 395-8 4 p.Research output: Contribution to journal › Article › peer-review
Expression of the major olive pollen allergen Ole e 10 in the yeast Pichia pastoris: evidence of post-translational modifications
Barral, P., Batanero, E., Villalba, M. & Rodríguez, R., Dec 2005, In: Protein Expression and Purification. 44, 2, p. 147-54 8 p.Research output: Contribution to journal › Article › peer-review
A recombinant functional variant of the olive pollen allergen Ole e 10 expressed in baculovirus system
Barral, P., Serrano, A. G., Batanero, E., Pérez-Gil, J., Villalba, M. & Rodríguez, R., 10 Feb 2006, In: JOURNAL OF BIOTECHNOLOGY. 121, 3, p. 402-9 8 p.Research output: Contribution to journal › Article › peer-review
Sensitization of mice with olive pollen allergen Ole e 1 induces a Th2 response
Batanero, E., Barral, P., Villalba, M. & Rodríguez, R., Apr 2002, In: International Archives of Allergy and Immunology. 127, 4, p. 269-75 7 p.Research output: Contribution to journal › Article › peer-review
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
Gaya, M., Barral, P., Burbage, M., Aggarwal, S., Montaner, B., Warren Navia, A., Aid, M., Tsui, C., Maldonado, P., Nair, U., Ghneim, K., Fallon, P. G., Sekaly, R.-P., Barouch, D. H., Shalek, A. K., Bruckbauer, A., Strid, J. & Batista, F. D., 25 Jan 2018, In: Cell. 172, 3, p. 517-533.E20Research output: Contribution to journal › Article › peer-review
CD1d-mediated activation of group 3 innate lymphoid cells drives IL-22 production
Saez De Guinoa, J., Jimeno, R., Farhadi, N., jervis, P., Cox, L., Besra, G. S. & Barral, P., 1 Jan 2017, In: EMBO Reports. 18, 1, p. 39-47Research output: Contribution to journal › Article › peer-review
Biodegradable poly (DL-lactide glycolide) microparticles as a vehicle for allergen-specific vaccines: a study performed with Ole e 1, the main allergen of olive pollen
Batanero, E., Barral, P., Villalba, M. & Rodríguez, R., 1 Jan 2002, In: Journal of Immunological Methods. 259, 1-2, p. 87-94 8 p.Research output: Contribution to journal › Article › peer-review
The role of major olive pollen allergens Ole e 1, Ole e 9, and Ole e 10 on mice sensitization
Barral, P., Villalba, M., Rodriguez, R. & Batanero, E., Mar 2006, In: Annals of Allergy Asthma and Immunology. 96, 3, p. 466-71 6 p.Research output: Contribution to journal › Article › peer-review
Synthetic iNKT cell-agonists as vaccine adjuvants--finding the balance
Cerundolo, V., Barral, P. & Batista, F. D., Jun 2010, In: Current Opinion in Immunology. 22, 3, p. 417-424 8 p.Research output: Contribution to journal › Article › peer-review
The role of integrins and coreceptors in refining thresholds for B-cell responses
Batista, F. D., Arana, E., Barral, P., Carrasco, Y. R., Depoil, D., Eckl-Dorna, J., Fleire, S., Howe, K., Vehlow, A., Weber, M. & Treanor, B., Aug 2007, In: Immunological Reviews. 218, p. 197-213 17 p.Research output: Contribution to journal › Article › peer-review
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor
Treanor, B., Depoil, D., Gonzalez-Granja, A., Barral, P., Weber, M., Dushek, O., Bruckbauer, A. & Batista, F. D., 26 Feb 2010, In: Immunity. 32, 2, p. 187-199 13 p.Research output: Contribution to journal › Article › peer-review
Neutrophils--the unexpected helpers of B-cell activation
Harwood, N. E., Barral, P. & Batista, F. D., Feb 2012, In: EMBO Reports. 13, 2, p. 93-94 2 p.Research output: Contribution to journal › Article › peer-review
Ash pollen immunoproteomics: Identification, immunologic characterization, and sequencing of 6 new allergens
Mas, S., Torres, M., Garrido-Arandia, M., Salamanca, G., Castro, L., Barral, P., Purohit, A., Pauli, G., Rodriguez, R., Batanero, E., Barderas, R. & Villalba, M., Mar 2014, In: Journal of Allergy and Clinical Immunology. 133, 3, p. 923-926.e3 5 p.Research output: Contribution to journal › Letter › peer-review
Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity.
Thaunat, O., Granja, A., Barral, P., Filby, A., Montaner, B., Collinson, L., Martinez-Martin, N., Harwood, N., Bruckbauer, A. & Batista, F., 27 Jan 2012, In: Science. 335, 6067, p. 475-479 5 p., N/A.Research output: Contribution to journal › Article › peer-review
Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
Chang, P.-P., Barral, P., Fitch, J., Patrama, A., Ma, C. S., Kallies, A., Hogan, J. J., Cerundolo, V., Tangye, S. G., Bittman, R., Nutt, S. L., Brink, R., Godfrey, D. I., Batista, F. D. & Vinuesa, C. G., Jan 2012, In: Nature Immunology. 13, 1, p. 35-43 9 p., N/A.Research output: Contribution to journal › Article › peer-review
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo
Barral, P., Eckl-Dorna, J., Harwood, N., De Santo, C., Salio, M., Illarionov, P., Besra, G., Cerundolo, V. & Batista, F., 17 Jun 2008, In: Proceedings of the National Academy of Science (USA). 105, 24, p. 8345-8350 6 p., N/A.Research output: Contribution to journal › Article › peer-review
The location of splenic NKT cells favours their rapid activation by blood-borne antigen
Barral, P., Sanchez-Nino, M., van Rooijen, N., Cerundolo, V. & Batista, F., 16 May 2012, In: EMBO J. 31, 10, p. 2378-2390 13 p., N/A.Research output: Contribution to journal › Article › peer-review
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
Chapman, J. R., Barral, P., Vannier, J.-B., Borel, V., Steger, M., Tomas-Loba, A., Sartori, A. A., Adams, I. R., Batista, F. D. & Boulton, S. J., 17 Jan 2013, In: Molecular Cell. 49, 5, p. 858-871 14 p., N/A.Research output: Contribution to journal › Article › peer-review
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes
Barral Catoira, P. B., Polzella, P., Bruckbauer, A., van Rooijen, N., Besra, G. S., Cerundolo, V. & Batista, F. D., Apr 2010, In: Nature Immunology. 11, 4, p. 303-12 10 p.Research output: Contribution to journal › Article › peer-review
News
King's researchers explain how lipids can control the immune response
The new paper from Dr Phillip Brailey, Dr Lauren Evans & Dr Patricia Barral highlights how lipids change the behaviour of macrophages which influences the...
People
PhD Student
Professor of Immunobiology
PhD Student
Postdoctoral Research Associate
Projects
Immunity in the intestine
We are investigating the mechanisms that regulate unconventional T cell functions in intestinal immunity. Through this work we have identified the cellular crosstalk controlling the activation of lipid-reactive NKT cells and explored the mechanisms by which NKT cells modulate intestinal epithelial cell fate and contribute to the establishment of intestinal homeostasis. We are currently investigating novel mechanisms by which NKT cells regulate epithelial regeneration in the context of intestinal inflammation.
Metabolic regulation of Immunity in cancer
While lipids have been traditionally regarded as quiescent components of cell membranes, in recent years it has become clear that lipid metabolism and the cellular lipid status play central roles in the regulation of immune cell activation and function. Our lab has recently identified a novel mechanistic link between innate immunity and cellular lipid metabolism. We are now exploring the mechanisms by which tissue derived signals control the immune lipidome, and how this in turn regulates immune cell activation and the outcome of immune responses particularly in the context of cancer.
Immunity in the skin
The skin is a complex immunological niche containing high numbers of immune cells that regulate skin homeostasis and protect from external insults. Unconventional T cells are present in the skin where they play a central role in the pathogenesis of skin diseases including psoriasis and atopic dermatitis. We aim to address how the interplay between unconventional T cell and the skin microbiome regulates skin health.
Publications
The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses
He, C., Wang, S., Moreews, M., Pei, S., Chen, G., Li, Q.-Z., Del Monte Monge, A., Ramiro, A., Cai, C., Gaya, M., Barral, P., Buggert, M., Batista, F. & Karlsson, M., 27 May 2025, In: Cell Reports. 44, 5, 115602.Research output: Contribution to journal › Article › peer-review
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
Acha-Sagredo, A., Andrei, P., Clayton, K., Taggart, E., Antoniotti, C., Woodman, C. A., Afrache, H., Fourny, C., Armero, M., Moinudeen, H. K., Green, M., Bhardwaj, N., Mikolajczak, A., Rodriguez-Lopez, M., Crawford, M., Connick, E., Lim, S., Hobson, P., Linares, J. & Ignatova, E. & 17 others, Pelka, D., Smyth, E. C., Diamantis, N., Sosnowska, D., Carullo, M., Ciraci, P., Bergamo, F., Intini, R., Nye, E., Barral, P., Mishto, M., Arnold, J. N., Lonardi, S., Cremolini, C., Fontana, E., Rodriguez-Justo, M. & Ciccarelli, F. D., 10 Feb 2025, In: CANCER CELL. 43, 2, p. 292-307.e7Research output: Contribution to journal › Article › peer-review
Mucosal associated invariant T cells: Powerhouses of the lung
Lopez Rodriguez, J. & Barral, P., Oct 2024, In: Immunology Letters. 269, 106910.Research output: Contribution to journal › Review article › peer-review
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
Lebrusant-Fernandez, M., Ap Rees, T., Jimeno, R., Angelis, N., Ng, J. C., Fraternali, F., Li, V. S. W. & Barral, P., Dec 2024, In: Cell Reports. 43, 12, p. 114948 114948.Research output: Contribution to journal › Article › peer-review
CD1 MOLECULES: BEYOND ANTIGEN PRESENTATION
Evans, L. & Barral, P., 2024, In: Molecular Immunology.Research output: Contribution to journal › Review article › peer-review
Type I interferons drive MAIT cell functions against bacterial pneumonia
Lopez Rodriguez, J., Hancock, S., Li, K., Crotta, S., Barrington, C., Suarez-Bonnet, A., Priestnall, S., Aube, J., Wack, A., Klenerman, P., Bengoechea, J. & Barral, P., 2 Oct 2023, In: The Journal of experimental medicine. 220, 10, e20230037.Research output: Contribution to journal › Article › peer-review
CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses
Brailey, P. M., Evans, L., Lopez-Rodriguez, J. C., Sinadinos, A., Tyrrel, V., Kelly, G., O’Donnell, V., Ghazal, P., John, S. & Barral, P., 7 Nov 2022, In: Nature Communications. 13, 1, 6723.Research output: Contribution to journal › Article › peer-review
NKT cells and the regulation of intestinal immunity: A two-way street.
Brailey, P. M., Lebrusant Fernandez, M. & Barral, P., 1 May 2020, In: FEBS Journal. 287, 9, p. 1686-1699 14 p.Research output: Contribution to journal › Review article › peer-review
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
Jimeno , R., Lebrusant-Fernandez, M., Margreitter, C., Lucas, B., Veerapen, N., Besra, G., Fraternali, F., Spencer, J., Anderson, G. & Barral, P., 24 Dec 2019, In: eLife. 8, e51663.Research output: Contribution to journal › Article › peer-review
Quantitative polymerase chain reaction-based analyses of murine intestinal microbiota after oral antibiotic treatment
Jimeno, R., Brailey, P. M. & Barral, P., 17 Nov 2018, In: Journal of Visualized Experiments. 2018, 141, e58481.Research output: Contribution to journal › Article › peer-review
qPCR-BASED ANALYSES OF INTESTINAL MICROBIOTA AFTER ORAL ANTIBIOTIC TREATMENT OF MICE
Jimeno , R., Brailey, P. M. & Barral , P., 2018, In: Journal of Visualized Experiments.Research output: Contribution to journal › Article › peer-review
CD1d-mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis
Sáez de Guinoa, J., Jimeno, R., Gaya, M., Kipling, D., Garzón, M. J., Dunn-Walters, D., Ubeda, C. & Barral, P., 1 Mar 2018, In: EMBO Journal. 37, 5, 17 p., e97537.Research output: Contribution to journal › Article › peer-review
NMR solution structure of Ole e 6, a major allergen from olive tree pollen
Treviño, M. A., García-Mayoral, M. F., Barral, P., Villalba, M., Santoro, J., Rico, M., Rodríguez, R. & Bruix, M., 10 Sept 2004, In: Journal of Biological Chemistry. 279, 37, p. 39035-41 7 p.Research output: Contribution to journal › Article › peer-review
Recombinant expression of Ole e 6, a Cys-enriched pollen allergen, in Pichia pastoris yeast: detection of partial oxidation of methionine by NMR
Barral, P., Tejera, M. L., Treviño, M. A., Batanero, E., Villalba, M., Bruix, M. & Rodríguez, R., Oct 2004, In: Protein expression and purification. 37, 2, p. 336-43 8 p.Research output: Contribution to journal › Article › peer-review
A major allergen from pollen defines a novel family of plant proteins and shows intra- and interspecies [correction of interspecie] cross-reactivity
Barral, P., Batanero, E., Palomares, O., Quiralte, J., Villalba, M. & Rodríguez, R., 15 Mar 2004, In: Journal of Immunology. 172, 6, p. 3644-51 8 p.Research output: Contribution to journal › Article › peer-review
An olive pollen protein with allergenic activity, Ole e 10, defines a novel family of carbohydrate-binding modules and is potentially implicated in pollen germination
Barral, P., Suárez, C., Batanero, E., Alfonso, C., Alché, J. D. D., Rodríguez-García, M. I., Villalba, M., Rivas, G. & Rodríguez, R., 15 Aug 2005, In: Biochemical Journal. 390, Pt 1, p. 77-84 8 p.Research output: Contribution to journal › Article › peer-review
Encapsulation of Ole e 1 in biodegradable microparticles induces Th1 response in mice: a potential vaccine for allergy
Batanero, E., Barral, P., Villalba, M. & Rodríguez, R., 30 Oct 2003, In: JOURNAL OF CONTROLLED RELEASE. 92, 3, p. 395-8 4 p.Research output: Contribution to journal › Article › peer-review
Expression of the major olive pollen allergen Ole e 10 in the yeast Pichia pastoris: evidence of post-translational modifications
Barral, P., Batanero, E., Villalba, M. & Rodríguez, R., Dec 2005, In: Protein Expression and Purification. 44, 2, p. 147-54 8 p.Research output: Contribution to journal › Article › peer-review
A recombinant functional variant of the olive pollen allergen Ole e 10 expressed in baculovirus system
Barral, P., Serrano, A. G., Batanero, E., Pérez-Gil, J., Villalba, M. & Rodríguez, R., 10 Feb 2006, In: JOURNAL OF BIOTECHNOLOGY. 121, 3, p. 402-9 8 p.Research output: Contribution to journal › Article › peer-review
Sensitization of mice with olive pollen allergen Ole e 1 induces a Th2 response
Batanero, E., Barral, P., Villalba, M. & Rodríguez, R., Apr 2002, In: International Archives of Allergy and Immunology. 127, 4, p. 269-75 7 p.Research output: Contribution to journal › Article › peer-review
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
Gaya, M., Barral, P., Burbage, M., Aggarwal, S., Montaner, B., Warren Navia, A., Aid, M., Tsui, C., Maldonado, P., Nair, U., Ghneim, K., Fallon, P. G., Sekaly, R.-P., Barouch, D. H., Shalek, A. K., Bruckbauer, A., Strid, J. & Batista, F. D., 25 Jan 2018, In: Cell. 172, 3, p. 517-533.E20Research output: Contribution to journal › Article › peer-review
CD1d-mediated activation of group 3 innate lymphoid cells drives IL-22 production
Saez De Guinoa, J., Jimeno, R., Farhadi, N., jervis, P., Cox, L., Besra, G. S. & Barral, P., 1 Jan 2017, In: EMBO Reports. 18, 1, p. 39-47Research output: Contribution to journal › Article › peer-review
Biodegradable poly (DL-lactide glycolide) microparticles as a vehicle for allergen-specific vaccines: a study performed with Ole e 1, the main allergen of olive pollen
Batanero, E., Barral, P., Villalba, M. & Rodríguez, R., 1 Jan 2002, In: Journal of Immunological Methods. 259, 1-2, p. 87-94 8 p.Research output: Contribution to journal › Article › peer-review
The role of major olive pollen allergens Ole e 1, Ole e 9, and Ole e 10 on mice sensitization
Barral, P., Villalba, M., Rodriguez, R. & Batanero, E., Mar 2006, In: Annals of Allergy Asthma and Immunology. 96, 3, p. 466-71 6 p.Research output: Contribution to journal › Article › peer-review
Synthetic iNKT cell-agonists as vaccine adjuvants--finding the balance
Cerundolo, V., Barral, P. & Batista, F. D., Jun 2010, In: Current Opinion in Immunology. 22, 3, p. 417-424 8 p.Research output: Contribution to journal › Article › peer-review
The role of integrins and coreceptors in refining thresholds for B-cell responses
Batista, F. D., Arana, E., Barral, P., Carrasco, Y. R., Depoil, D., Eckl-Dorna, J., Fleire, S., Howe, K., Vehlow, A., Weber, M. & Treanor, B., Aug 2007, In: Immunological Reviews. 218, p. 197-213 17 p.Research output: Contribution to journal › Article › peer-review
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor
Treanor, B., Depoil, D., Gonzalez-Granja, A., Barral, P., Weber, M., Dushek, O., Bruckbauer, A. & Batista, F. D., 26 Feb 2010, In: Immunity. 32, 2, p. 187-199 13 p.Research output: Contribution to journal › Article › peer-review
Neutrophils--the unexpected helpers of B-cell activation
Harwood, N. E., Barral, P. & Batista, F. D., Feb 2012, In: EMBO Reports. 13, 2, p. 93-94 2 p.Research output: Contribution to journal › Article › peer-review
Ash pollen immunoproteomics: Identification, immunologic characterization, and sequencing of 6 new allergens
Mas, S., Torres, M., Garrido-Arandia, M., Salamanca, G., Castro, L., Barral, P., Purohit, A., Pauli, G., Rodriguez, R., Batanero, E., Barderas, R. & Villalba, M., Mar 2014, In: Journal of Allergy and Clinical Immunology. 133, 3, p. 923-926.e3 5 p.Research output: Contribution to journal › Letter › peer-review
Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity.
Thaunat, O., Granja, A., Barral, P., Filby, A., Montaner, B., Collinson, L., Martinez-Martin, N., Harwood, N., Bruckbauer, A. & Batista, F., 27 Jan 2012, In: Science. 335, 6067, p. 475-479 5 p., N/A.Research output: Contribution to journal › Article › peer-review
Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
Chang, P.-P., Barral, P., Fitch, J., Patrama, A., Ma, C. S., Kallies, A., Hogan, J. J., Cerundolo, V., Tangye, S. G., Bittman, R., Nutt, S. L., Brink, R., Godfrey, D. I., Batista, F. D. & Vinuesa, C. G., Jan 2012, In: Nature Immunology. 13, 1, p. 35-43 9 p., N/A.Research output: Contribution to journal › Article › peer-review
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo
Barral, P., Eckl-Dorna, J., Harwood, N., De Santo, C., Salio, M., Illarionov, P., Besra, G., Cerundolo, V. & Batista, F., 17 Jun 2008, In: Proceedings of the National Academy of Science (USA). 105, 24, p. 8345-8350 6 p., N/A.Research output: Contribution to journal › Article › peer-review
The location of splenic NKT cells favours their rapid activation by blood-borne antigen
Barral, P., Sanchez-Nino, M., van Rooijen, N., Cerundolo, V. & Batista, F., 16 May 2012, In: EMBO J. 31, 10, p. 2378-2390 13 p., N/A.Research output: Contribution to journal › Article › peer-review
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
Chapman, J. R., Barral, P., Vannier, J.-B., Borel, V., Steger, M., Tomas-Loba, A., Sartori, A. A., Adams, I. R., Batista, F. D. & Boulton, S. J., 17 Jan 2013, In: Molecular Cell. 49, 5, p. 858-871 14 p., N/A.Research output: Contribution to journal › Article › peer-review
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes
Barral Catoira, P. B., Polzella, P., Bruckbauer, A., van Rooijen, N., Besra, G. S., Cerundolo, V. & Batista, F. D., Apr 2010, In: Nature Immunology. 11, 4, p. 303-12 10 p.Research output: Contribution to journal › Article › peer-review
News
King's researchers explain how lipids can control the immune response
The new paper from Dr Phillip Brailey, Dr Lauren Evans & Dr Patricia Barral highlights how lipids change the behaviour of macrophages which influences the...
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