The Bieling Group investigates how cells organize themselves and change shape by studying the interactions between signalling molecules at membranes and the actin cytoskeleton - a dynamic network of protein filaments that provides structural support and mechanical force. We are particularly interested in how actin regulators, such as Rho GTPases, generate spatial activity patterns at membranes and how these signals guide the assembly of different actin structures that push or pull the cell.

Rather than studying these processes in their full cellular complexity, we take a bottom-up approach by reconstituting them from purified components. Our work combines protein and lipid biochemistry, advanced imaging and biophysics and we closely collaborate with experts in cell and structural biology. By recreating molecular systems in a controlled environment outside the cell, we can uncover the fundamental mechanisms that drive cell shape changes and movement.