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King's College London
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Biomarkers of substance use and abuse

A study is ongoing to explore Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for the management of inflammatory pain in Bayelsa State Nigeria comparing use in different regions of the State to include different occupations. The research looks at prescribing practices in the community and in hospital to establish the prevalence of use and those most commonly used against current local, national and international guidelines.

In a separate study work has been ongoing for several years looking at substance misuse in pregnant women. Research has taken place both in the UK and in Malta with consideration for parenting and the placement of offspring born to mothers who misuse substances. In Malta, the effect of prenatal opioid exposure on neurological milestone development and the influence of type of guardianship was investigated in a prospective longitudinal 3-year follow-up study of 69 new-borns with developmental milestones compared to standardised general population quotients. Whilst in the UK the identification of opioid dependence in pregnancy and outcomes of neonates exposed in utero to methadone has been explored.

Investigators

Dr Auyeung, Vivian

Senior Lecturer

Dr Jane Marshall

Honorary Senior Lecturer

Prof Atholl Johnstone

Visiting Professor

Dr Lewis Couchman

Visiting Lecturer

Dr Caroline Pollard

Researcher

Dr Anna Vella

Senior Lecturer

Joanne Thomas

PhD Student

Peter Owonaro

PhD Student

 

Aims

The use of self-report data alongside more objective tools to gain insight into drug use by different populations.

Trials Design

Cross sectional studies

Publications

  1. Wang M, Stapleton JA, Wolff K (2018) Methadone Dose as a Determinant of Infant Outcome during the Peri and Postnatal Period, Heroin Addict Related Clin Prob Published July 2018
  2. Wang M, Shen J, Liu X, Deng Y, Li J, Finch E, Wolff K. (2017) Reliability and Validity of the Treatment Outcome Profile among Patients Attending Methadone Maintenance Treatment Programs in Kunming, China. J Substance Abuse Treatment, 77: 89-94
  3. Ali K, Rosser T, Bhat R, Wolff K, Hannam S, Rafferty GF, Greenough A (2016) Antenatal smoking and substance-misuse, infant and new-born response to hypoxia. Pediatr Pulmonol. 2016 Oct 10. doi: 10.1002/ppul.23620. [Epub ahead of print]
  4. Ali K, Rosser T, Bhat R, Wolff K, Hannam S, Rafferty GF, Greenough A. (2016) Ventilatory responses to hypercarbia in infants of smoking and substance-misusing mothers. J Pediatrics (Clinical Laboratory Observation). May 20. doi: 10.1016/j.jpeds .2016.04.078. [Epub ahead of print]
  5. Ali K, Rossor T, Bhat R, Wolff K, Hannam S, Rafferty GF, Peacock JL, Greenough A (2016) Antenatal substance misuse and smoking and new-born hypoxic challenge response. Arch Dis Child Fetal Neonatal Ed. 101:F143-8 doi: 10.1136/archdischild-2015-308491.
  6. Vella A, Ventura CS, Wolff K (2015). A Demographic Overview of a 10-year Retrospective Study of Substance Misusing Pregnant Women. March 2015 Euro J Obstet & Gynae, 2015 Oct 14:1-5.
  7. Wolff K & Perez-Montejano R. (2014) Opioid Neonatal Abstinence Syndrome: controversies and implications for practice. Current Drug Abuse Rev. 2014;7(1):44-58.
  8. Ali K, Wolff K, Peakcock J, Hanam S, Rafferty GF, Bhat R, Greenough A. (2014) Ventilatory response to hypercarbia in newborns of smoking and substance misusing mothers. Annals Am Thorac Soc. 11:993-8 online 01 Jul 2014 as DOI: 10.1513/AnnalsATS. 2014 03-124OC.
  9. Wang M, Shen J, Deng Y, Liu X, Li J, Wolff K, Finch E. (2014) Association of higher-risk alcohol consumption with injecting paraphernalia sharing behaviours in intravenous drug users. Am J Drug Alcohol Abuse. 40:137-42. doi: 10.3109/00952990.2013.861844. Epub 2014 Feb 12.
  10. Wolff K & Perez-Montejano R. (2014) Opioid Neonatal Abstinence Syndrome: controversies and implications for practice. Current Drug Abuse Rev. 2014;7(1):44-58.
  11. Perez-Montejano R, Finch E, Wolff K. (2013) A national survey investigating methadone treatment for pregnant opioid dependent Internat J Mental Health & Addict. 2013 Online first (DOI) 10.1007/s11469-013-9447-0

Reports

  1. Thomas J., Wolff K. (2016). Diagnosis of neonatal abstinence syndrome: Substance use During Pregnancy. Heroin Addiction and Related Clinical Problems, 18(5), 43-48.
  2. Wolff K & Latt N, (2016) Chapter 24 Special Populations: Pregnancy and the neonate. Pp 505514 Editors Saunders JB, Conigrave KM, Latt NC, Nutt DJ, Marshall EJ, Ling W, Higuchi S, Addiction Medicine, 2nd Edition, Oxford University Press, London, ISBN 978-0-19-871475-0.

Publications

  1. Wang M, Stapleton JA, Wolff K (2018) Methadone Dose as a Determinant of Infant Outcome during the Peri and Postnatal Period, Heroin Addict Related Clin Prob Published July 2018
  2. Wang M, Shen J, Liu X, Deng Y, Li J, Finch E, Wolff K. (2017) Reliability and Validity of the Treatment Outcome Profile among Patients Attending Methadone Maintenance Treatment Programs in Kunming, China. J Substance Abuse Treatment, 77: 89-94
  3. Ali K, Rosser T, Bhat R, Wolff K, Hannam S, Rafferty GF, Greenough A (2016) Antenatal smoking and substance-misuse, infant and new-born response to hypoxia. Pediatr Pulmonol. 2016 Oct 10. doi: 10.1002/ppul.23620. [Epub ahead of print]
  4. Ali K, Rosser T, Bhat R, Wolff K, Hannam S, Rafferty GF, Greenough A. (2016) Ventilatory responses to hypercarbia in infants of smoking and substance-misusing mothers. J Pediatrics (Clinical Laboratory Observation). May 20. doi: 10.1016/j.jpeds .2016.04.078. [Epub ahead of print]
  5. Ali K, Rossor T, Bhat R, Wolff K, Hannam S, Rafferty GF, Peacock JL, Greenough A (2016) Antenatal substance misuse and smoking and new-born hypoxic challenge response. Arch Dis Child Fetal Neonatal Ed. 101:F143-8 doi: 10.1136/archdischild-2015-308491.
  6. Vella A, Ventura CS, Wolff K (2015). A Demographic Overview of a 10-year Retrospective Study of Substance Misusing Pregnant Women. March 2015 Euro J Obstet & Gynae, 2015 Oct 14:1-5.
  7. Wolff K & Perez-Montejano R. (2014) Opioid Neonatal Abstinence Syndrome: controversies and implications for practice. Current Drug Abuse Rev. 2014;7(1):44-58.
  8. Ali K, Wolff K, Peakcock J, Hanam S, Rafferty GF, Bhat R, Greenough A. (2014) Ventilatory response to hypercarbia in newborns of smoking and substance misusing mothers. Annals Am Thorac Soc. 11:993-8 online 01 Jul 2014 as DOI: 10.1513/AnnalsATS. 2014 03-124OC.
  9. Wang M, Shen J, Deng Y, Liu X, Li J, Wolff K, Finch E. (2014) Association of higher-risk alcohol consumption with injecting paraphernalia sharing behaviours in intravenous drug users. Am J Drug Alcohol Abuse. 40:137-42. doi: 10.3109/00952990.2013.861844. Epub 2014 Feb 12.
  10. Wolff K & Perez-Montejano R. (2014) Opioid Neonatal Abstinence Syndrome: controversies and implications for practice. Current Drug Abuse Rev. 2014;7(1):44-58.
  11. Perez-Montejano R, Finch E, Wolff K. (2013) A national survey investigating methadone treatment for pregnant opioid dependent Internat J Mental Health & Addict. 2013 Online first (DOI) 10.1007/s11469-013-9447-0

Reports

  1. Thomas J., Wolff K. (2016). Diagnosis of neonatal abstinence syndrome: Substance use During Pregnancy. Heroin Addiction and Related Clinical Problems, 18(5), 43-48.
  2. Wolff K & Latt N, (2016) Chapter 24 Special Populations: Pregnancy and the neonate. Pp 505514 Editors Saunders JB, Conigrave KM, Latt NC, Nutt DJ, Marshall EJ, Ling W, Higuchi S, Addiction Medicine, 2nd Edition, Oxford University Press, London, ISBN 978-0-19-871475-0.
Project status: Ongoing

Principal Investigator

Contact us

kim.wolff@kcl.ac.uk

Keywords

FORENSICS