Bone Marrow Failure & Myelodisplastic Syndromes

The Bone Marrow Failure (BMF) Team specialises in comprising acquired aplastic anaemia (AA), myelodysplastic syndromes (MDS) and paroxysmal nocturnal haemoglobinuria (PNH). Collectively these disorders are chronic, associated with considerable morbidity and mortality and more likely to transform to MDS/acute myeloid leukaemia (AML).

Our group consists of a dedicated team of scientists and clinicians with access to state of the art equipment which enables us to study wide-spectrum of aspects of bone marrow failure syndromes including; karyotyping by SNP analysis, expression profiling of mRNA and microRNA, mutation analysis by next generation sequencing, DNA damage repair and immunoregulation.

King’s College Hospital (KCH) is unique in the UK and the rest of Europe in providing national and international clinical and research expertise in these disorders. Our clinical partners, the adult haemopoietic stem cell/bone marrow transplant unit at King’s College Hospital are the largest in the UK and the only one to provide a specialist service for AA.