Imaging cancer and immune cell activity at nanoscale We apply Optical Imaging/Biophysics at a nanoscopic scale (by deploying fluorescence lifetime imaging) to interrogate Cancer biological events including the Immunological synapse protein interactions (Ng T, et al. Imaging protein kinase C activation in cells. Science (1999) 283: 2085-2089 & Carlin LM, et al. Cdc42 activity oscillates during NK cell immune surveillance. Science Signalling 2011 doi 2001729). These techniques are also adapted for use in clinical patient samples.