The CAR Mechanics Group originated in 2004 and has sought to develop and translate novel CAR T-cell strategies for the treatment of patients with refractory solid tumours. We have developed several experimental CAR approaches in addition to ancillary technologies that enable improved CAR T-cell expansion and homing to sites of disease. The CAR Mechanics Group has advanced one candidate named T4 immunotherapy to Phase 1 clinical trial evaluation with funding from the Jon Moulton Charitable Foundation, Wellcome Trust and the Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust.
People
Research Assistant
Research Associate
PhD Student
Consultant and Senior Lecturer in Immunology
Research Associate
Projects
CAR T-cell immunotherapy of solid tumours
The CAR Mechanics group has a number of projects focused on the development of novel CAR-T solutions for patients with solid tumours. Please contact the PI if you are interested in working or studying in the group.
Publications
Awards
Wellcome Trust (£773,419; 2014-2023) “T4 immunotherapy – phase 1 clinical trial in patients with head and neck cancer”.
Principal Supervisor - Medical Research Council Clinical Research Studentship (£281,214; 2017-2021). Combination immunotherapy for solid tumours with oncolytic virus & cognate CAR T-cells
Breast Cancer Now (£229,844; 2019-2022) CAR T cell mediated co-targeting of MUC1 and HER2 to achieve precision immunotherapy of breast cancer.
British Lung Foundation (£149,977; 2019-2021) Immunotherapy for malignant mesothelioma using IL-6 neutralising CAR T cells.
The Moulton Charitable Foundation (£689,269; 2020-2022). Immunotherapy of Head and Neck Cancer using T4 CAR T-cells potentiated by lymphodepletion and nivolumab.
People
Research Assistant
Research Associate
PhD Student
Consultant and Senior Lecturer in Immunology
Research Associate
Projects
CAR T-cell immunotherapy of solid tumours
The CAR Mechanics group has a number of projects focused on the development of novel CAR-T solutions for patients with solid tumours. Please contact the PI if you are interested in working or studying in the group.
Publications
Awards
Wellcome Trust (£773,419; 2014-2023) “T4 immunotherapy – phase 1 clinical trial in patients with head and neck cancer”.
Principal Supervisor - Medical Research Council Clinical Research Studentship (£281,214; 2017-2021). Combination immunotherapy for solid tumours with oncolytic virus & cognate CAR T-cells
Breast Cancer Now (£229,844; 2019-2022) CAR T cell mediated co-targeting of MUC1 and HER2 to achieve precision immunotherapy of breast cancer.
British Lung Foundation (£149,977; 2019-2021) Immunotherapy for malignant mesothelioma using IL-6 neutralising CAR T cells.
The Moulton Charitable Foundation (£689,269; 2020-2022). Immunotherapy of Head and Neck Cancer using T4 CAR T-cells potentiated by lymphodepletion and nivolumab.
PhD students
Our Partners
Group lead
Consultant and Senior Lecturer in Immunology