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Our group is focused on developing chimeric antigen receptor T cells for haematological malignancies with a particular interest in gene edited allogeneic CAR T cells. We are exploring the mechanisms of resistance of myeloma, lymphoma and CLL towards CAR T cells using multi-OMICS assays and by evaluating primary samples from patients treated with CD19 and BCMA targeted CAR T cells.

People

Reuben Benjamin

Clinical Senior Lecturer

Molly George

PhD Student

Arief Gunawan

Honorary Senior Lecturer

Senior Research Assistant

Visiting Research Fellow

Projects

Evaluating the use of 'off the shelf' CAR-T cells for B-cell haematological malignancies

    Investigating mechanisms of resistance of multiple myeloma to anti-BCMA CAR T cells

      Exploring the immunobiology of extramedullary myeloma

        Publications

          News

          New CAR T-cell immunotherapy shows promising results for treating blood cancer patients

          The CALM clinical trial has highlighted the therapeutic potential of UCART19 and other ‘off-the-shelf’ CAR T-cell products in their treatment of blood cancer.

          Blood cells web image

          Researchers publish study showcasing breakthrough treatment of CAR T cells for patients with blood cancer

          A multidisciplinary collaboration involving researchers from the School of Cancer & Pharmaceutical Sciences provides evidence for the benefits of...

          blood cancer

          Alumni

          Alumni:

          • Dr Ana Martins Metelo
          • Dr Charlotte Graham (Clinical Senior Lecturer)
          • Dr Agnieszka Jozwik
          • Dr Ieuan Walker
          • Delaney Dominey-Foy
          • Eniola Etti

          People

          Reuben Benjamin

          Clinical Senior Lecturer

          Molly George

          PhD Student

          Arief Gunawan

          Honorary Senior Lecturer

          Senior Research Assistant

          Visiting Research Fellow

          Projects

          Evaluating the use of 'off the shelf' CAR-T cells for B-cell haematological malignancies

            Investigating mechanisms of resistance of multiple myeloma to anti-BCMA CAR T cells

              Exploring the immunobiology of extramedullary myeloma

                Publications

                  News

                  New CAR T-cell immunotherapy shows promising results for treating blood cancer patients

                  The CALM clinical trial has highlighted the therapeutic potential of UCART19 and other ‘off-the-shelf’ CAR T-cell products in their treatment of blood cancer.

                  Blood cells web image

                  Researchers publish study showcasing breakthrough treatment of CAR T cells for patients with blood cancer

                  A multidisciplinary collaboration involving researchers from the School of Cancer & Pharmaceutical Sciences provides evidence for the benefits of...

                  blood cancer

                  Alumni

                  Alumni:

                  • Dr Ana Martins Metelo
                  • Dr Charlotte Graham (Clinical Senior Lecturer)
                  • Dr Agnieszka Jozwik
                  • Dr Ieuan Walker
                  • Delaney Dominey-Foy
                  • Eniola Etti