Our group is focused on developing chimeric antigen receptor T cells for haematological malignancies with a particular interest in gene edited allogeneic CAR T cells. We are exploring the mechanisms of resistance of myeloma, lymphoma and CLL towards CAR T cells using multi-OMICS assays and by evaluating primary samples from patients treated with CD19 and BCMA targeted CAR T cells.
Projects
Evaluating the use of 'off the shelf' CAR-T cells for B-cell haematological malignancies
Investigating mechanisms of resistance of multiple myeloma to anti-BCMA CAR T cells
Exploring the immunobiology of extramedullary myeloma
Publications
News
New CAR T-cell immunotherapy shows promising results for treating blood cancer patients
The CALM clinical trial has highlighted the therapeutic potential of UCART19 and other ‘off-the-shelf’ CAR T-cell products in their treatment of blood cancer.

Researchers publish study showcasing breakthrough treatment of CAR T cells for patients with blood cancer
A multidisciplinary collaboration involving researchers from the School of Cancer & Pharmaceutical Sciences provides evidence for the benefits of...

Alumni
Alumni:
- Dr Ana Martins Metelo
- Dr Charlotte Graham (Clinical Senior Lecturer)
- Dr Agnieszka Jozwik
- Dr Ieuan Walker
- Delaney Dominey-Foy
- Eniola Etti
Projects
Evaluating the use of 'off the shelf' CAR-T cells for B-cell haematological malignancies
Investigating mechanisms of resistance of multiple myeloma to anti-BCMA CAR T cells
Exploring the immunobiology of extramedullary myeloma
Publications
News
New CAR T-cell immunotherapy shows promising results for treating blood cancer patients
The CALM clinical trial has highlighted the therapeutic potential of UCART19 and other ‘off-the-shelf’ CAR T-cell products in their treatment of blood cancer.

Researchers publish study showcasing breakthrough treatment of CAR T cells for patients with blood cancer
A multidisciplinary collaboration involving researchers from the School of Cancer & Pharmaceutical Sciences provides evidence for the benefits of...

Alumni
Alumni:
- Dr Ana Martins Metelo
- Dr Charlotte Graham (Clinical Senior Lecturer)
- Dr Agnieszka Jozwik
- Dr Ieuan Walker
- Delaney Dominey-Foy
- Eniola Etti