Peptide - enhanced scaffolds for tissue regeneration Bone tissue engineering has attracted considerable attention as a promising treatment modality for damaged or diseased tissues. Vascularization and integration with host tissue remains a major challenge in large defect bone tissue reconstruction. Peptides have demonstrated unique biological and self-assembly characteristics that are increasingly being exploited as bioactive molecules combined with biomaterials. The uniqueness of self-assembly proteins (SAPs) is the ability to recapitulate the environmental niche by providing cues such as nano-topography guidance, binding to extracellular matrix and transduction of mechanical force. The long-term goal of this project is to develop bespoke 3D printed scaffolds functionalized with SAP’s to promote angiogenesis and bone ingrowth in challenging critical size defects. To date, we have demonstrated pro-angiogenic properties of a self-assembly peptide enhanced scaffold, which by virtue of its structure at the nanometres level primes endothelial cells (EC) for angiogenesis, and in vivo, has demonstrated a reduction in fibrotic tissue formation.