Ellison-Hughes Group

Our research focuses on understanding the role of tissue-specific stem cells in the homeostasis and regeneration of striated (skeletal and cardiac) muscle, for repair and maintenance of muscle tissue, particularly preventing and treating a loss of muscle mass (i.e. with ageing and/or disease).

Our research has been at the forefront of pioneering research on adult-derived cardiac stem cells since its inception and has made a seminal contribution in the paradigm-shifting work to establish the adult heart as a self-renewing organ with regenerative capacity.

Current PhD student:
Tom Francis
Ben Grimsdell
Yu Han
Sarah Kendall
Punkita Lohiya

Members

Georgina Ellison-Hughes

Professor of Regenerative Muscle Physiology

Dimitris Tampakis

Research Assistant

Red and yellow visualisation of the novel coronavirus

Coronavirus Literature Review Task Force

This task force is researching the literature on COVID-19 and SARS-Cov2, and producing short reports on possible treatments.

Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells
Smith, A. J., Ruchaya, P., Walmsley, R., Wright, K. E., Lewis-McDougall, F. C., Bond, J. & Ellison-Hughes, G. M., Dec 2022, In: Scientific Reports. 12, 1, 10132. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41598-022-13203-3
Human primary skeletal muscle-derived myoblasts and fibroblasts reveal different senescent phenotypes
Francis, T., Jaka, O., Ellison, G., Lazarus, N. R. & Harridge, S., 14 Jun 2022, In: Wiley. Research output: Contribution to journal › Article. DOIs: https://doi.org/10.1002/rco2.67
Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age
Marino, F., Scalise, M., Salerno, N., Salerno, L., Molinaro, C., Cappetta, D., Torella, M., Greco, M., Foti, D., Sasso, F. C., Mastroroberto, P., De Angelis, A., Ellison-Hughes, G. M., Sampaolesi, M., Rota, M., Rossi, F., Urbanek, K., Nadal-Ginard, B., Torella, D. & Cianflone, E., 1 May 2022, In: Diabetes. 71, 5, p. 1081-1098 18 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.2337/db21-0536
A protocol for extracting immunolabeled murine cardiomyocytes of high-quality RNA by laser capture microdissection
Shaalan, A. K. & Ellison-Hughes, G. M., 18 Mar 2022, In: STAR Protocols. 3, 1, 101231. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.xpro.2022.101231
Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms
Zhu, R., Yan, T., Feng, Y., Liu, Y., Cao, H., Peng, G., Yang, Y., Xu, Z., Liu, J., Hou, W., Wang, X., Li, Z., Deng, L., Wang, S., Li, J., Han, Q., Li, H., Shan, G., Cao, Y., An, X. & 32 others, Yan, J., Zhang, Z., Li, H., Qu, X., Zhu, J., Zhou, S., Wang, J., Zhang, F., Gao, J., Jin, R., Xu, D., Ma, Y. Q., Huang, T., Peng, S., Zheng, Z., Stambler, I., Gilson, E., Lim, L. W., Moskalev, A., Cano, A., Chakrabarti, S., Ulfhake, B., Su, H., Xu, H., Xu, S., Wei, F., Brown-Borg, H. M., Min, K. J., Ellison-Hughes, G., Caruso, C., Jin, K. & Zhao, R. C., Dec 2021, In: CELL RESEARCH. 31, 12, p. 1244-1262 19 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41422-021-00573-y
Atrial Myxomas Arise From Multipotent Cardiac Stem Cells
Scalise, M., Torella, M., Marino, F., Ravo, M., Giurato, G., Vicinanza, C., Cianflone, E., Mancuso, T., Aquila, I., Salerno, L., Nassa, G., Agosti, V., De Angelis, A., Urbanek, K., Veltri, P., Paolino, D., Mastroroberto, P., De Feo, M., Viglietto, G., Weisz, A. & 3 others, Nadal-Ginard, B., Ellison-Hughes, G. M. & Torella, D., 1 Dec 2020, In: European Heart Journal. 41, 45, p. 4332-4345 14 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/eurheartj/ehaa156
Vascular Manifestations of COVID-19 – Thromboembolism and Microvascular Dysfunction
Roberts, K. A., Colley, L., Agbaedeng, T. A., Ellison-Hughes, G. M. & Ross, M. D., 26 Oct 2020, In: Frontiers in Cardiovascular Medicine. 7, 598400. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3389/fcvm.2020.598400
Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia
Ellison, G., 1 Feb 2020, In: Aging and Disease. 11, 2, p. 216-228 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.14336/AD.2020.0228
Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with particular focus on the heart
Ellison-Hughes, G. M., 2020, In: Expert Opinion on Therapeutic Targets. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1080/14728222.2020.1798403
Aged-senescent cells contribute to impaired heart regeneration
Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Teoh, T. S., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 2019, In: AGING CELL. 18, 3, e12931. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/acel.12931

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Our partners

Wellcome Trust

British Heart Foundation

Medical Research Council

Contact us

georgina.ellison@kcl.ac.uk

Ellison-Hughes Group

Members

Georgina Ellison-Hughes

Dimitris Tampakis

Coronavirus Literature Review Task Force

Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells

Human primary skeletal muscle-derived myoblasts and fibroblasts reveal different senescent phenotypes

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age

A protocol for extracting immunolabeled murine cardiomyocytes of high-quality RNA by laser capture microdissection

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Atrial Myxomas Arise From Multipotent Cardiac Stem Cells

Vascular Manifestations of COVID-19 – Thromboembolism and Microvascular Dysfunction

Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with particular focus on the heart

Aged-senescent cells contribute to impaired heart regeneration

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