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Research & Innovation

Ellison-Hughes Group

Our research focuses on understanding the role of tissue-specific stem cells in the homeostasis and regeneration of striated (skeletal and cardiac) muscle, for repair and maintenance of muscle tissue, particularly preventing and treating a loss of muscle mass (i.e. with ageing and/or disease).

Our research has been at the forefront of pioneering research on adult-derived cardiac stem cells since its inception and has made a seminal contribution in the paradigm-shifting work to establish the adult heart as a self-renewing organ with regenerative capacity.

Current PhD student:
Tom Francis
Ben Grimsdell
Yu Han
Sarah Kendall
Punkita Lohiya

Members

Georgina Ellison-Hughes

Professor of Regenerative Muscle Physiology

Dimitris Tampakis

Research Assistant

Red and yellow visualisation of the novel coronavirus

Coronavirus Literature Review Task Force

This task force is researching the literature on COVID-19 and SARS-Cov2, and producing short reports on possible treatments.

Atrial Myxomas Arise From Multipotent Cardiac Stem Cells
Scalise, M., Torella, M., Marino, F., Ravo, M., Giurato, G., Vicinanza, C., Cianflone, E., Mancuso, T., Aquila, I., Salerno, L., Nassa, G., Agosti, V., De Angelis, A., Urbanek, K., Veltri, P., Paolino, D., Mastroroberto, P., De Feo, M., Viglietto, G., Weisz, A. & 3 others, Nadal-Ginard, B., Ellison-Hughes, G. M. & Torella, D., 24 Apr 2020, In : European Heart Journal. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1093/eurheartj/ehaa156https://doi.org/10.1093/eurheartj/ehaa156
Aged-senescent cells contribute to impaired heart regeneration
Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Teoh, T. S., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 2019, In : AGING CELL. 18, 3, e12931. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/acel.12931
c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration
Aquila, I., Cianflone, E., Scalise, M., Marino, F., Mancuso, T., Filardo, A., Smith, A. J., Cappetta, D., De Angelis, A., Urbanek, K., Isidori, A. M., Torella, M., Agosti, V., Viglietto, G., Nadal-Ginard, B., Ellison-Hughes, G. M. & Torella, D., 2019, In : Cell Death and Disease. 10, 19 p., 436. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41419-019-1655-5
Adult cardiac stem cells are multipotent and robustly myogenic: C-kit expression is necessary but not sufficient for their identification
Vicinanza, C., Aquila, I., Scalise, M., Cristiano, F., Marino, F., Cianflone, E., Mancuso, T., Marotta, P., Sacco, W., Lewis, F. C., Couch, L., Shone, V., Gritti, G., Torella, A., Smith, A. J., Terracciano, C. M., Britti, D., Veltri, P., Indolfi, C., Nadal-Ginard, B. & 2 others, Ellison-Hughes, G. & Torella, D., Dec 2017, In : CELL DEATH AND DIFFERENTIATION. 24, 12, p. 2101-2116 16 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/cdd.2017.130
Non-invasive strategies for stimulating endogenous repair and regenerative mechanisms in the damaged heart
Lewis, F. C., Ellison-Hughes, G. M. & Deva Kumar, S., 2 Sep 2017, In : Pharmacological Research. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.phrs.2017.08.016
Skeletal muscle-derived interstitialprogenitor cells (PICs) display stem cellproperties, being clonogenic, self-renewing,and multi-potent in vitro and in vivo
Cottle, B. J., Lewis, F. C., Shone, V. L. & Ellison, G. M., 4 Jul 2017, In : Stem cell research & therapy. 8, 158. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1186/s13287-017-0612-4
Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
Lewis, F. C., Cottle, B. J., Shone, V., Marazzi, G., Sassoon, D., Tseng, C. C. S., Dankers, P. Y. W., Chamuleau, S. A. J., Nadal-Ginard, B. & Ellison-Hughes, G. M., 2017, In : JACC: Basic to Translational Science. 2, 6, p. 717-736 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.jacbts.2017.08.002
Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery
Ellison-Hughes, G. M. & Madeddu, P., 1 Dec 2016, (Accepted/In press) In : Pharmacology and Therapeutics. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.pharmthera.2016.11.007
Basic science behind the cardiovascular benefits of exercise
Wilson, M. G., Ellison, G. M. & Cable, N. T., 1 Jan 2016, In : British Journal of Sports Medicine. 50, 2, p. 93-99 7 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1136/bjsports-2014-306596rep
Basic science behind the cardiovascular benefits of exercise
Wilson, M. G., Ellison, G. M. & Cable, N. T., Dec 2015, In : Postgraduate Medical Journal. 91, 1082, p. 704-11 8 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1136/postgradmedj-2014-306596rep

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Our partners

Wellcome Trust

British Heart Foundation

Medical Research Council

Contact us

georgina.ellison@kcl.ac.uk