Research & Innovation

This clinical trial will investigate if home High-Flow Therapy (HFT) improves 12-month admission-free survival (time to readmission or death) following a severe exacerbation of COPD requiring hospitalisation. This is an area of unmet need, given the demonstrable limitations to current interventions which are costly, have extensive side-effects, limited availability and variable efficacy. If this this clinical trial demonstrates clinical and cost effectiveness of HFT, this technology could be rapidly incorporated into routine NHS clinical practice.

Open sites: 

• Guy's and St. Thomas Hospital
• Leeds Teaching Hospital
• Royal Free Hospital/Barnet Hospital
• Northumbria Healthcare-North Tyneside
• Liverpool University Hospitals
• Queen Elizabeth Hospital-Glasgow
• University of Leicester
• University Hospitals Birmingham-Heartlands Hospital/Good Hope Hospital
• Nottingham University Hospital
• Manchester University Hospitals
• Mid-Yorkshire Teaching Hospitals
• Sheffield Teaching Hospitals
• King's College Hospital
• Taunton and Somerset NHS
• Newcastle University
• East Lancashire Hospitals

Recruitment to 10/06/2025: 181/502

Download the EPiC-HFT fact sheet (pdf, English)