CLEM is an imaging technique that combines fluorescence light microscopy (FM) and electron microscopy (EM) to analyse the same region of a biological sample. It merges the molecular specificity of FM with the high-resolution structural details of EM, allowing researchers to visualise, locate, and track specific molecules within their cellular context.

CLEM is crucial for understanding the relationship between structure and function at a subcellular level.

Equipment available

• JEOL JEM 1400Flash
• JEOL JEM F200.