The Thermo Scientific Orbitrap Eclipse Tribrid Mass Spectrometer is a high‑performance platform widely adopted in proteomics for its sensitivity, resolution, and experimental flexibility. Built on Thermo Scientific Tribrid architecture, combining a quadrupole mass filter, an Orbitrap mass analyser, and a linear ion trap, the Eclipse delivers information‑rich data ideal for complex proteomic workflows.

The Eclipse is suited for diverse applications - global proteomics, PTM mapping, protein–protein interaction analyses, immunopeptidomes, and structural proteomics, offering the versatility required for cutting‑edge biological and translational research.

For quantitative proteomics, features such as Real‑Time Search (RTS) and TurboTMT enhance TMT‑based workflows by increasing specificity, acquisition speed, and depth of peptide identification. Electron Transfer Dissociation (ETD) capabilities allow robust characterisation of post translational modifications in complex biological samples.

The mass spectrometer is connected in line with Thermo Scientific Vanquish Neo nanoLC system to allow high resolution chromatographic separation of trace amounts of biological materials to improve the sensitivity of detection.

King's Proteomics Facility also accesses state-of-the-art mass spectrometers housed within King's Smart Trails Hub - Orbitrap Astral mass spectrometer and Orbitrap Ascend Multiomics mass spectrometer for advanced high throughput proteomics applications.