The Euro BioImaging UK Node offers open-access to a wide range of advanced biological imaging techniques including correlative, multi-modal, high-content and super-resolution. It is a multi-sited national infrastructure hosted by the following seven leading institutions spread across the UK:
- Edinburgh Super-Resolution Imaging Consortium (ESRIC)
- The Francis Crick Institute
- King’s College London
- Liverpool University
- Octopus at Harwell
- Oxford Brookes University
- York University
They all offer state-of-the-art imaging equipment, expertise, training and image data services. These technologies can be applied to a wide range of research projects, from molecular to cellular resolution, single cells to 3D models, and whole organisms.
The UK Node welcomes applications from all biological and biomedical research disciplines. Projects are prioritised based on technical feasibility and scientific merit. Support is available throughout the experimental pipeline, including initial consultation, experimental planning, hands-on training, sample preparation, high-quality imaging and data analysis.
King’s College London offer: STORM ,SIM, Lightsheet, FLIM, CLEM, Volume EM, LA-ICP-MS and Raman Imaging.
At atomic and nano scales, King’s supports volume EM and CLEM workflows, cryo SEM and cryo TEM, and freeze fracture techniques. Cryo-focused ion beam SEM is available, and a pipeline is being developed from live cell to cryo ET for sub-tomographic averaging of proteins in situ.
For super-resolution and live-cell imaging, the N-STORM 5.0, SoRa, and single/multi-photon lightsheet is available, as well as high-content and throughput spinning disc (Opera Phenix).
Beyond optical imaging, multi-modal analytical imaging, including 2D and 3D spatial quantitative elemental and molecular imaging is available. This includes LA-ICP-MS integrated with DESI-MS and Raman spectroscopy in a unique correlative workflow, plus IR integration for high-resolution mapping of lipids, nucleic acids and protein phosphorylation.
Applications are made through the Euro-BioImaging web portal. Creating a user account is quick and easy.
Funding opportunities are available on the Euro-BioImaging webpage and visits to research infrastructures can be included on many grant applications.
The Euro-BioImaging UK Node Manager, acts as the single point of contact and can direct users to the right technology and site for their experiments.