The Fear Lab is currently investigating molecular mechanisms regulating Human B cell germinal centre activities. In particular, identifying transcription factors, chromatin remodelling enzymes and microRNAs that regulate B cell fate and the regulation of class switching to IgE and behaviour of IgE+ B cells.
People
Senior Lecturer
Projects
Transcriptomic profiling of IgE producing B cells
We have previously shown that the isotype of antibody that B cells produce profound effects on their function, survival, longevity and differentiation potential. Critically, naïve B cells undergo Immunoglobulin class switching less readily than memory or germinal centre B cells and switchless frequently to IgE than to IgG6. But, IgE+ B cells show more rapid differentiation to plasma cells than IgG+ cells whilst retaining their proliferative capacity. We are now employing population level and single-cell transcriptomic profiling of different Naïve, IgE+ and IgG+ B cell populations to understand the mechanisms that regulate their different behaviour.
Identification of transcription factors and miRNAs that regulate B cell activities
We have identified many transcription factors and miRNAs that are differentially expressed at specific stages of B cell activation and differentiation. We are now using siRNA and CRISPR/Cas9 technologies to manipulate the expression of these factors to elucidate their role in B cell regulation.
Publications
Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function
George, M. S., Sanchez, J., Rollings, C., Fear, D., Irving, P., Sinclair, L. V. & Schurich, A., 18 Aug 2023, In: iScience. 26, 8, 107280.Research output: Contribution to journal › Article › peer-review
SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and Postvaccination
Moore, T., Hossain, R., Doores, K. J., Shankar-Hari, M. & Fear, D. J., 2 Aug 2022, In: Viral Immunology. 35, 6, p. 425-436 12 p.Research output: Contribution to journal › Article › peer-review
SARS-CoV-2-specific memory B cell responses are maintained after recovery from natural infection and post vaccination
Fear, D., 1 Jul 2022, (Accepted/In press) In: Viral Immunology.Research output: Contribution to journal › Article › peer-review
Quantitative assessment of NFκB transcription factor activity
Hunter, T. T. J., Fear, D., Lavender, P., Spencer, J., Peakman, M. & Ibrahim, M. A. A., May 2021, In: Journal of Immunological Methods. 492, 112954.Research output: Contribution to journal › Article › peer-review
Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy
Sharif, H., Acharya, S., Dhondalay, G. K. R., Varricchi, G., Krasner-Macleod, S., Laisuan, W., Switzer, A., Lenormand, M., Kashe, E., Parkin, R. V., Yi, Y., Koc, M., Fedina, O., Vilà-Nadal, G., Marone, G., Eifan, A., Scadding, G. W., Fear, D. J., Nadeau, K. C. & Durham, S. R. & 1 others, Shamji, M. H., 2020, (Accepted/In press) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Human marginal zone B cell development from early T2 progenitors
Spencer, J., Tull, T., Pitcher, M., Guesdon, W., Siu, J. H., Lebraro-Fernandez, C., Zhao, Y., Petrov, N., Heck, S., Ellis, R., Dhami, P., kadolsky, U., Kleeman, M., Kamra, Y., Fear, D., John, S., Jassem, W., Groves, R., Sanderson, J. D. & Robson, M. & 2 others, D’Cruz, D. & Bemark, M., 5 Apr 2021, In: Journal of Experimental Medicine. 218, 4, e20202001.Research output: Contribution to journal › Article › peer-review
Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment
Xu, L., Faruqu, F. N., Lim, Y. M., Lim, K. Y., Liam-Or, R., Walters, A. A., Lavender, P., Fear, D., Wells, C. M., Tzu-Wen Wang, J. & Al-Jamal, K. T., Jan 2021, In: Biomaterials. 264, 120369.Research output: Contribution to journal › Article › peer-review
Transcriptional analysis of the human IgE-expressing plasma cell differentiation pathway
Ramadani, F., Bowen, H., Gould, H. J. & Fear, D. J., 11 Mar 2019, In: Frontiers in Immunology. 10, MAR, 1 p., 402.Research output: Contribution to journal › Article › peer-review
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Zhao, Y., Uduman, M., Siu, J., Tull, T. J., Sanderson, J., Wu, Y.-C. B., Zhou, J. Q., Petrov, N., Ellis, R. J., Todd, S. K., Chavele, K.-M., Guesdon, W. W. J., Vossenkamper, A., Jassem, W., D’Cruz, D., Fear, D. J., John, S., Scheel-Toellner, D., hopkins, C. & Moreno, E. & 6 others, Woodman, N., Ciccarelli, F. D., Heck, S., Kleinstein, S., Bemark, M. & Spencer, J. M., 21 Sept 2018, In: Nature Communications. 9, 1, 15 p., 3857.Research output: Contribution to journal › Article › peer-review
miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in naïve B cells
Recaldin, T., Hobson, P. S., Mann, E. H., Ramadani, F., Cousins, D. J., Lavender, P. & Fear, D. J., Sept 2018, In: Molecular Immunology. 101, p. 419-428Research output: Contribution to journal › Article › peer-review
BET proteins are a key component of immunoglobulin gene expression
Shim, J. M., Lee, J. S., Russell, K. E., Wiegman, C. H., Barnes, P. J., Fear, D., Adcock, I. M. & Durham, A. L., 1 Apr 2017, In: Epigenomics. 9, 4, p. 393-406 14 p.Research output: Contribution to journal › Article › peer-review
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis
Shankar-Hari, M., Fear, D., Lavender, P., Mare, T., Beale, R., Swanson, C., Singer, M. & Spencer, J., May 2017, In: Critical Care Medicine. 45, 5, p. 875-882 8 p.Research output: Contribution to journal › Article › peer-review
Global gene regulation during activation of immunoglobulin class switching in human B cells
Zhang, Y., Fear, D. J., Willis-Owen, S. A. G., Cookson, W. O. & Moffatt, M. F., 29 Nov 2016, In: Scientific Reports. 6, 37988.Research output: Contribution to journal › Article › peer-review
IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin
Saul, L., Ilieva, K. M., Bax, H. J., Karagiannis, P., Correa, I., Rodriguez-Hernandez, I., Josephs, D. H., Tosi, I., Egbuniwe, I. U., Lombardi, S., Crescioli, S., Hobbs, C., Villanova, F., Cheung, A., Geh, J. L. C., Healy, C., Harries, M., Sanz-Moreno, V., Fear, D. J. & Spicer, J. F. & 3 others, Lacy, K. E., Nestle, F. O. & Karagiannis, S. N., 14 Jul 2016, In: Scientific Reports. 6, 29736.Research output: Contribution to journal › Article › peer-review
Ontogeny of Human IgE-expressing B Cells and Plasma Cells
Ramadani, F., Bowen, H., Upton, N., Hobson, P. S., Chan, Y.-C., Chen, J.-B., Chang, T. W., McDonnell, J. M., Sutton, B. J., Fear, D. J. & Gould, H. J., 1 Jan 2017, In: Allergy. 72, 1, p. 66-76 10 p.Research output: Contribution to journal › Article › peer-review
Transcription factors regulating B cell fate in the germinal centre
Recaldin, T. & Fear, D. J., Jan 2016, In: Clinical and Experimental Immunology. 183, 1, p. 65-75 11 p.Research output: Contribution to journal › Article › peer-review
Intrinsic Properties of Germinal Centre-derived B cells Promote their Enhanced Class Switching to IgE
Ramadani, F., Upton, N. E. G., Hobson, P. S., Chan, Y.-C., Mzinza, D., Bowen, H., Kerridge, C., Sutton, B. J., Fear, D. J. & Gould, H. J., 25 Oct 2015, In: Allergy. 70, 10, p. 1269-1277 9 p.Research output: Contribution to journal › Article › peer-review
Mechanisms regulating the targeting and activity of Activation Induced cytidine Deaminase
Fear, D., Oct 2013, In: Current Opinion in Immunology. 25, 5, p. 619–628 10 p., N/A.Research output: Contribution to journal › Article › peer-review
Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination
Nedbal, J., Hobson, P. S., Fear, D. J., Heintzmann, R. & Gould, H., 14 Dec 2012, In: PLoS ONE. 7, 12, p. N/A 7 p., e51675.Research output: Contribution to journal › Article › peer-review
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Gevaert, P., Nouri-Aria, K. T., Wu, H., Harper, C. E., Takhar, P., Fear, D. J., Acke, F., De Ruyck, N., Banfield, G., Kariyawasam, H. H., Bachert, C., Durham, S. R. & Gould, H., Jan 2013, In: Allergy. 68, 1, p. 55-63 9 p.Research output: Contribution to journal › Article › peer-review
IgG4 subclass antibodies impair antitumor immunity in melanoma
Karagiannis, P., Gilbert, A. E., Josephs, D. H., Ali, N., Dodev, T., Saul, L., Correa, I., Roberts, L., Beddowes, E., Koers, A., Hobbs, C., Ferreira, S., Geh, J., Healy, C., Harries, M., Acland, K. M., Blower, P. J., Mitchell, T., Fear, D. J. & Spicer, J. F. & 3 others, Lacy, K. E., Nestle, F. O. & Karagiannis, S. N., 1 Apr 2013, In: Journal of Clinical Investigation. 123, 4, p. 1457–1474 18 p.Research output: Contribution to journal › Article › peer-review
Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells
Cooper, A. M., Hobson, P. S., Jutton, M. R., Kao, M. W., Drung, B., Schmidt, B., Fear, D. J., Beavil, A. J., McDonnell, J. M., Sutton, B. J. & Gould, H. J., 1 Apr 2012, In: Journal of Immunology. 188, 7, p. 3199 - 3207 9 p.Research output: Contribution to journal › Article › peer-review
High Resolution Analysis of the Chromatin Landscape of the IgE Switch Region in Human B Cells
Dayal, S., Nedbal, J., Hobson, P., Cooper, A. M., Gould, H. J., Gellert, M., Felsenfeld, G. & Fear, D. J., 20 Sept 2011, In: PL o S One . 6, 9, e24571.Research output: Contribution to journal › Article › peer-review
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus
Chowdhury, M., Forouhi, O., Dayal, S., McCloskey, N., Gould, H. J., Felsenfeld, G. & Fear, D. J., 14 Oct 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15872 - 15877 6 p.Research output: Contribution to journal › Article › peer-review
Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
Kerr, J. R., Burke, B., Petty, R., Gough, J., Fear, D., Mattey, D. L., Axford, J. S., Dalgleish, A. G. & Nutt, D. J., Jun 2008, In: Journal of Clinical Pathology. 61, 6, p. 730 - 739 10 p.Research output: Contribution to journal › Article › peer-review
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
Kerr, J. R., Petty, R., Burke, B., Gough, J., Fear, D., Sinclair, L. I., Mattey, D. L., Richards, S. C. M., Montgomery, J., Baldwin, D. A., Kellam, P., Harrison, T. J., Griffin, G. E., Main, J., Enlander, D., Nutt, D. J. & Holgate, S. T., 15 Apr 2008, In: Journal of Infectious Diseases. 197, 8, p. 1171 - 1184 14 p.Research output: Contribution to journal › Article › peer-review
IgE-antibody-dependent immunotherapy of solid tumors: Cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells
Karagiannis, S., Bracher, M. G., Hunt, J., McCloskey, N., Beavil, R. L., Beavil, A. J., Fear, D. J., Thompson, R. G., East, N., Burke, F., Moore, R. J., Dombrowicz, D. D., Balkwill, F. R. & Gould, H. J., 1 Sept 2007, In: Journal of Immunology. 179, 5, p. 2832 - 2843 12 p.Research output: Contribution to journal › Article › peer-review
Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells
McCloskey, N., Hunt, J., Beavil, R. L., Jutton, M. R., Grundy, G. J., Girardi, E., Fabiane, S. M., Fear, D. J., Conrad, D. H., Sutton, B. J. & Gould, H. J., 17 Aug 2007, In: Journal of Biological Chemistry. 282, 33, p. 24083 - 24091 9 p.Research output: Contribution to journal › Article › peer-review
Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
Takhar, P., Smurthwaite, L., Coker, H. A., Fear, D. J., Banfield, G. K., Carr, V. A., Durham, S. R. & Gould, H. J., 15 Apr 2005, In: Journal of Immunology. 174, 8, p. 5024 - 5032 9 p.Research output: Contribution to journal › Article › peer-review
The biology of IgE and the basis of allergic disease
Gould, H. J., Sutton, B. J., Beavil, A. J., Beavil, R. L., McCloskey, N., Coker, H. A., Fear, D. & Smurthwaite, L., 2003, In: Annual Review of Immunology. 21, p. 579 - 628 50 p.Research output: Contribution to journal › Literature review › peer-review
Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination
Fear, D. J., McCloskey, N., O'Connor, B., Felsenfeld, G. & Gould, H. J., 1 Oct 2004, In: Journal of Immunology. 173, 7, p. 4529 - 4538 10 p.Research output: Contribution to journal › Article › peer-review
Characterization of antibody responses in malignant melanoma
Karagiannis, P., Beddowes, E., Gilbert, A. E., Abu-Nab, Z., Fear, D., Gould, H. J., Lacy, K., Nestle, F. O. & Karagiannis, S., 2010, In: British Journal of Dermatology. 162, 4, p. 935 - 935 1 p.Research output: Contribution to journal › Meeting abstract
Immunoglobulin Gene Organization and Expression and Regulation of IgE
Gould, H. & Fear, D., 2008, Allergy and Allergic Diseases . Blackwell Scientific, p. 119 - 140 22 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
PhD students
People
Senior Lecturer
Projects
Transcriptomic profiling of IgE producing B cells
We have previously shown that the isotype of antibody that B cells produce profound effects on their function, survival, longevity and differentiation potential. Critically, naïve B cells undergo Immunoglobulin class switching less readily than memory or germinal centre B cells and switchless frequently to IgE than to IgG6. But, IgE+ B cells show more rapid differentiation to plasma cells than IgG+ cells whilst retaining their proliferative capacity. We are now employing population level and single-cell transcriptomic profiling of different Naïve, IgE+ and IgG+ B cell populations to understand the mechanisms that regulate their different behaviour.
Identification of transcription factors and miRNAs that regulate B cell activities
We have identified many transcription factors and miRNAs that are differentially expressed at specific stages of B cell activation and differentiation. We are now using siRNA and CRISPR/Cas9 technologies to manipulate the expression of these factors to elucidate their role in B cell regulation.
Publications
Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function
George, M. S., Sanchez, J., Rollings, C., Fear, D., Irving, P., Sinclair, L. V. & Schurich, A., 18 Aug 2023, In: iScience. 26, 8, 107280.Research output: Contribution to journal › Article › peer-review
SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and Postvaccination
Moore, T., Hossain, R., Doores, K. J., Shankar-Hari, M. & Fear, D. J., 2 Aug 2022, In: Viral Immunology. 35, 6, p. 425-436 12 p.Research output: Contribution to journal › Article › peer-review
SARS-CoV-2-specific memory B cell responses are maintained after recovery from natural infection and post vaccination
Fear, D., 1 Jul 2022, (Accepted/In press) In: Viral Immunology.Research output: Contribution to journal › Article › peer-review
Quantitative assessment of NFκB transcription factor activity
Hunter, T. T. J., Fear, D., Lavender, P., Spencer, J., Peakman, M. & Ibrahim, M. A. A., May 2021, In: Journal of Immunological Methods. 492, 112954.Research output: Contribution to journal › Article › peer-review
Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy
Sharif, H., Acharya, S., Dhondalay, G. K. R., Varricchi, G., Krasner-Macleod, S., Laisuan, W., Switzer, A., Lenormand, M., Kashe, E., Parkin, R. V., Yi, Y., Koc, M., Fedina, O., Vilà-Nadal, G., Marone, G., Eifan, A., Scadding, G. W., Fear, D. J., Nadeau, K. C. & Durham, S. R. & 1 others, Shamji, M. H., 2020, (Accepted/In press) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Human marginal zone B cell development from early T2 progenitors
Spencer, J., Tull, T., Pitcher, M., Guesdon, W., Siu, J. H., Lebraro-Fernandez, C., Zhao, Y., Petrov, N., Heck, S., Ellis, R., Dhami, P., kadolsky, U., Kleeman, M., Kamra, Y., Fear, D., John, S., Jassem, W., Groves, R., Sanderson, J. D. & Robson, M. & 2 others, D’Cruz, D. & Bemark, M., 5 Apr 2021, In: Journal of Experimental Medicine. 218, 4, e20202001.Research output: Contribution to journal › Article › peer-review
Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment
Xu, L., Faruqu, F. N., Lim, Y. M., Lim, K. Y., Liam-Or, R., Walters, A. A., Lavender, P., Fear, D., Wells, C. M., Tzu-Wen Wang, J. & Al-Jamal, K. T., Jan 2021, In: Biomaterials. 264, 120369.Research output: Contribution to journal › Article › peer-review
Transcriptional analysis of the human IgE-expressing plasma cell differentiation pathway
Ramadani, F., Bowen, H., Gould, H. J. & Fear, D. J., 11 Mar 2019, In: Frontiers in Immunology. 10, MAR, 1 p., 402.Research output: Contribution to journal › Article › peer-review
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Zhao, Y., Uduman, M., Siu, J., Tull, T. J., Sanderson, J., Wu, Y.-C. B., Zhou, J. Q., Petrov, N., Ellis, R. J., Todd, S. K., Chavele, K.-M., Guesdon, W. W. J., Vossenkamper, A., Jassem, W., D’Cruz, D., Fear, D. J., John, S., Scheel-Toellner, D., hopkins, C. & Moreno, E. & 6 others, Woodman, N., Ciccarelli, F. D., Heck, S., Kleinstein, S., Bemark, M. & Spencer, J. M., 21 Sept 2018, In: Nature Communications. 9, 1, 15 p., 3857.Research output: Contribution to journal › Article › peer-review
miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in naïve B cells
Recaldin, T., Hobson, P. S., Mann, E. H., Ramadani, F., Cousins, D. J., Lavender, P. & Fear, D. J., Sept 2018, In: Molecular Immunology. 101, p. 419-428Research output: Contribution to journal › Article › peer-review
BET proteins are a key component of immunoglobulin gene expression
Shim, J. M., Lee, J. S., Russell, K. E., Wiegman, C. H., Barnes, P. J., Fear, D., Adcock, I. M. & Durham, A. L., 1 Apr 2017, In: Epigenomics. 9, 4, p. 393-406 14 p.Research output: Contribution to journal › Article › peer-review
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis
Shankar-Hari, M., Fear, D., Lavender, P., Mare, T., Beale, R., Swanson, C., Singer, M. & Spencer, J., May 2017, In: Critical Care Medicine. 45, 5, p. 875-882 8 p.Research output: Contribution to journal › Article › peer-review
Global gene regulation during activation of immunoglobulin class switching in human B cells
Zhang, Y., Fear, D. J., Willis-Owen, S. A. G., Cookson, W. O. & Moffatt, M. F., 29 Nov 2016, In: Scientific Reports. 6, 37988.Research output: Contribution to journal › Article › peer-review
IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin
Saul, L., Ilieva, K. M., Bax, H. J., Karagiannis, P., Correa, I., Rodriguez-Hernandez, I., Josephs, D. H., Tosi, I., Egbuniwe, I. U., Lombardi, S., Crescioli, S., Hobbs, C., Villanova, F., Cheung, A., Geh, J. L. C., Healy, C., Harries, M., Sanz-Moreno, V., Fear, D. J. & Spicer, J. F. & 3 others, Lacy, K. E., Nestle, F. O. & Karagiannis, S. N., 14 Jul 2016, In: Scientific Reports. 6, 29736.Research output: Contribution to journal › Article › peer-review
Ontogeny of Human IgE-expressing B Cells and Plasma Cells
Ramadani, F., Bowen, H., Upton, N., Hobson, P. S., Chan, Y.-C., Chen, J.-B., Chang, T. W., McDonnell, J. M., Sutton, B. J., Fear, D. J. & Gould, H. J., 1 Jan 2017, In: Allergy. 72, 1, p. 66-76 10 p.Research output: Contribution to journal › Article › peer-review
Transcription factors regulating B cell fate in the germinal centre
Recaldin, T. & Fear, D. J., Jan 2016, In: Clinical and Experimental Immunology. 183, 1, p. 65-75 11 p.Research output: Contribution to journal › Article › peer-review
Intrinsic Properties of Germinal Centre-derived B cells Promote their Enhanced Class Switching to IgE
Ramadani, F., Upton, N. E. G., Hobson, P. S., Chan, Y.-C., Mzinza, D., Bowen, H., Kerridge, C., Sutton, B. J., Fear, D. J. & Gould, H. J., 25 Oct 2015, In: Allergy. 70, 10, p. 1269-1277 9 p.Research output: Contribution to journal › Article › peer-review
Mechanisms regulating the targeting and activity of Activation Induced cytidine Deaminase
Fear, D., Oct 2013, In: Current Opinion in Immunology. 25, 5, p. 619–628 10 p., N/A.Research output: Contribution to journal › Article › peer-review
Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination
Nedbal, J., Hobson, P. S., Fear, D. J., Heintzmann, R. & Gould, H., 14 Dec 2012, In: PLoS ONE. 7, 12, p. N/A 7 p., e51675.Research output: Contribution to journal › Article › peer-review
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Gevaert, P., Nouri-Aria, K. T., Wu, H., Harper, C. E., Takhar, P., Fear, D. J., Acke, F., De Ruyck, N., Banfield, G., Kariyawasam, H. H., Bachert, C., Durham, S. R. & Gould, H., Jan 2013, In: Allergy. 68, 1, p. 55-63 9 p.Research output: Contribution to journal › Article › peer-review
IgG4 subclass antibodies impair antitumor immunity in melanoma
Karagiannis, P., Gilbert, A. E., Josephs, D. H., Ali, N., Dodev, T., Saul, L., Correa, I., Roberts, L., Beddowes, E., Koers, A., Hobbs, C., Ferreira, S., Geh, J., Healy, C., Harries, M., Acland, K. M., Blower, P. J., Mitchell, T., Fear, D. J. & Spicer, J. F. & 3 others, Lacy, K. E., Nestle, F. O. & Karagiannis, S. N., 1 Apr 2013, In: Journal of Clinical Investigation. 123, 4, p. 1457–1474 18 p.Research output: Contribution to journal › Article › peer-review
Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells
Cooper, A. M., Hobson, P. S., Jutton, M. R., Kao, M. W., Drung, B., Schmidt, B., Fear, D. J., Beavil, A. J., McDonnell, J. M., Sutton, B. J. & Gould, H. J., 1 Apr 2012, In: Journal of Immunology. 188, 7, p. 3199 - 3207 9 p.Research output: Contribution to journal › Article › peer-review
High Resolution Analysis of the Chromatin Landscape of the IgE Switch Region in Human B Cells
Dayal, S., Nedbal, J., Hobson, P., Cooper, A. M., Gould, H. J., Gellert, M., Felsenfeld, G. & Fear, D. J., 20 Sept 2011, In: PL o S One . 6, 9, e24571.Research output: Contribution to journal › Article › peer-review
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus
Chowdhury, M., Forouhi, O., Dayal, S., McCloskey, N., Gould, H. J., Felsenfeld, G. & Fear, D. J., 14 Oct 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15872 - 15877 6 p.Research output: Contribution to journal › Article › peer-review
Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
Kerr, J. R., Burke, B., Petty, R., Gough, J., Fear, D., Mattey, D. L., Axford, J. S., Dalgleish, A. G. & Nutt, D. J., Jun 2008, In: Journal of Clinical Pathology. 61, 6, p. 730 - 739 10 p.Research output: Contribution to journal › Article › peer-review
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
Kerr, J. R., Petty, R., Burke, B., Gough, J., Fear, D., Sinclair, L. I., Mattey, D. L., Richards, S. C. M., Montgomery, J., Baldwin, D. A., Kellam, P., Harrison, T. J., Griffin, G. E., Main, J., Enlander, D., Nutt, D. J. & Holgate, S. T., 15 Apr 2008, In: Journal of Infectious Diseases. 197, 8, p. 1171 - 1184 14 p.Research output: Contribution to journal › Article › peer-review
IgE-antibody-dependent immunotherapy of solid tumors: Cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells
Karagiannis, S., Bracher, M. G., Hunt, J., McCloskey, N., Beavil, R. L., Beavil, A. J., Fear, D. J., Thompson, R. G., East, N., Burke, F., Moore, R. J., Dombrowicz, D. D., Balkwill, F. R. & Gould, H. J., 1 Sept 2007, In: Journal of Immunology. 179, 5, p. 2832 - 2843 12 p.Research output: Contribution to journal › Article › peer-review
Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells
McCloskey, N., Hunt, J., Beavil, R. L., Jutton, M. R., Grundy, G. J., Girardi, E., Fabiane, S. M., Fear, D. J., Conrad, D. H., Sutton, B. J. & Gould, H. J., 17 Aug 2007, In: Journal of Biological Chemistry. 282, 33, p. 24083 - 24091 9 p.Research output: Contribution to journal › Article › peer-review
Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
Takhar, P., Smurthwaite, L., Coker, H. A., Fear, D. J., Banfield, G. K., Carr, V. A., Durham, S. R. & Gould, H. J., 15 Apr 2005, In: Journal of Immunology. 174, 8, p. 5024 - 5032 9 p.Research output: Contribution to journal › Article › peer-review
The biology of IgE and the basis of allergic disease
Gould, H. J., Sutton, B. J., Beavil, A. J., Beavil, R. L., McCloskey, N., Coker, H. A., Fear, D. & Smurthwaite, L., 2003, In: Annual Review of Immunology. 21, p. 579 - 628 50 p.Research output: Contribution to journal › Literature review › peer-review
Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination
Fear, D. J., McCloskey, N., O'Connor, B., Felsenfeld, G. & Gould, H. J., 1 Oct 2004, In: Journal of Immunology. 173, 7, p. 4529 - 4538 10 p.Research output: Contribution to journal › Article › peer-review
Characterization of antibody responses in malignant melanoma
Karagiannis, P., Beddowes, E., Gilbert, A. E., Abu-Nab, Z., Fear, D., Gould, H. J., Lacy, K., Nestle, F. O. & Karagiannis, S., 2010, In: British Journal of Dermatology. 162, 4, p. 935 - 935 1 p.Research output: Contribution to journal › Meeting abstract
Immunoglobulin Gene Organization and Expression and Regulation of IgE
Gould, H. & Fear, D., 2008, Allergy and Allergic Diseases . Blackwell Scientific, p. 119 - 140 22 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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