Skeletal Development: Making and Shaping Bones The aim is to understand the role of the Fat4-Dchs1 signalling pathway during mammalian development. This is an essential pathway for human development as mutations in Fat4 and Dchs1 result in Van Maldergem’s syndrome characterized by a number of developmental defects including altered craniofacial development. Fat4 and Dchs1 act together to coordinate cell polarity and growth via the Hippo pathway. Fat4 and Dchs1 mouse mutants have alterations in cell organization and proliferation which alter the development, size and shape of bones. The bones in mutants can be shorter and wider (e.g. sternum) or smaller (e.g. cranial bones). This project will investigate how Fat4 and Dchs1 control skeletal development by analysing cell shapes and organization within developing bones and the identification of transcriptional targets of Fat4-Dchs1 signalling.