Professor of Immune Regulation in Allergic Diseases
Vitamin D status in pregnancy and the impact on immune function and health of the newborn
These immune studies are linked to two clinical trials (USA & India) of comparatively high dose vitamin D supplementation from the end of the 1st trimester of pregnancy to term. They are investigating how maternal vitamin D status in early and late pregnancy influences the immune response of the newborn, including neonatal specific mechanisms and effector cells. The focus is on mechanisms linked to risk factors for the development of asthma (allergy, infection) as well as infections of importance in LMIC.
The impact of particulate matter air pollution on immune function relevant to respiratory health and protective effects of vitamin D
Particulate matter (PM) is heterogenous making it difficult to investigate molecular mechanisms underlying PM-induced respiratory inflammation. The majority of studies to date have utilised standard reference PM samples, that are unrepresentative of modern-day PM samples derived from diverse geographical locations. This heterogeneity underlines the importance of chemical characterisation when investigating cellular effects of real-world PM. Individuals with chronic respiratory disease, including treatment refractory asthmatics who often exhibit Th17 airway inflammation, are particularly susceptible to periods of poor air quality. In order to gain insight into potential signalling pathways involved in immune activation by PM, a range of real-word samples from London (PM10 and PM2.5) and Thailand (PM2.5; urban and rural) are being compositionally characterised, and their capacit¬¬¬y to mature dendritic cells (DC) and activate memory CD4 T cells from healthy donors and asthma patients is being compared The capacity of vitamin D treatment to ameliorate PM-induced inflammation is being assessed.
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Scichilone, N., Barnes, P. J., Battaglia, S., Benfante, A., Brown, R., Canonica, G. W., Caramori, G., Cazzola, M., Centanni, S., Cianferoni, A., Corsico, A., De Carlo, G., Di Marco, F., Gaga, M., Hawrylowicz, C., Heffler, E., Matera, M. G., Matucci, A., Paggiaro, P., Papi, A., & 6 othersPopov, T., Rogliani, P., Santus, P., Solidoro, P., Togias, A. & Boulet, L. P., 1 Aug 2020, In: Journal of Clinical Medicine. 9, 8, p. 1-27 27 p., 2397. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/jcm9082397
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Zhang, G. Q., Chen, J. L., Luo, Y., Mathur, M. B., Anagnostis, P., Nurmatov, U., Talibov, M., Zhang, J., Hawrylowicz, C. M., Lumsden, M. A., Critchley, H., Sheikh, A., Lundbäck, B., Lässer, C., Kankaanranta, H., Lee, S. H. & Nwaru, B. I., Aug 2021, In: PLoS Medicine. 18, 8, e1003731. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1371/journal.pmed.1003731
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Hawrylowicz, C. M., Chen, Y-H., Cheadle, C. E., Rice, L. V., Pfeffer, P. E., Dimeloe, S., Gupta, A. & Bush, A., 12 Aug 2021, In: Frontiers in Nutrition. 8, 667203. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fnut.2021.667203
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Nwaru, B. I., Shah, S. A., Tibble, H., Pillinger, R., McLean, S., Ryan, D., Critchley, H., Hawrylowicz, C. M., Simpson, C. R., Soyiri, I. N., Appiagyei, F., Price, D. & Sheikh, A., Jul 2021, In: Journal of Allergy and Clinical Immunology: In Practice. 9, 7, p. 2751-2760.e1 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jaip.2021.02.052
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Shah, S. A., Tibble, H., Pillinger, R., McLean, S., Ryan, D., Critchley, H., Price, D., Hawrylowicz, C. M., Simpson, C. R., Soyiri, I. N., Appiagyei, F., Sheikh, A. & Nwaru, B. I., May 2021, In: Journal of Allergy and Clinical Immunology. 147, 5, p. 1662-1670 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jaci.2020.11.024
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Nwaru, B. I., Tibble, H., Shah, S. A., Pillinger, R., McLean, S., Ryan, D. P., Critchley, H., Price, D. B., Hawrylowicz, C. M., Simpson, C. R., Soyiri, I. N., Appiagyei, F. & Sheikh, A., 2020, (Accepted/In press) In: Thorax. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1136/thoraxjnl-2020-215540
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Cheadle, C. E., Glencross, D. A. & Hawrylowicz, C. M., 17 Nov 2020, In: Immunity. 53, 5, p. 900-902 3 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.immuni.2020.10.019
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Khatiwada, A., Wolf, B. J., Mulligan, J. K., Shary, J. R., Hewison, M., Baatz, J. E., Newton, D. A., Hawrylowicz, C., Hollis, B. W. & Wagner, C. L., 1 Jan 2020, (Accepted/In press) In: Pediatric Research. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41390-020-0885-7
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Nwaru, B. I., Pillinger, R., Tibble, H., Shah, S. A., Ryan, D., Critchley, H., Price, D., Hawrylowicz, C. M., Simpson, C. R., Soyiri, I. N., Appiagyei, F. & Sheikh, A., Aug 2020, In: Journal of Allergy and Clinical Immunology. 146, 2, p. 438-446 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jaci.2020.02.027
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Mann, E. H., Pfeffer, P. E. & Hawrylowicz, C. M., 14 Dec 2017, Health, Disease and Therapeutics. Elsevier Inc., Vol. 2. p. 937-949 13 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review. DOIs: https://doi.org/10.1016/B978-0-12-809963-6.00104-8