Unravelling the role of fluoxetine in the regulation of beta-cell mass and function
Prof Shanta Persaud, Dr Bo Liu, Dr James Bowe, Dr Inma Ruz Maldonado, Dr Lorna Smith, Miss Klaudia Toczyska - Management of depression using Prozac®, which contains the active pharmaceutical ingredient fluoxetine, can lead to reductions in plasma glucose and glycated haemoglobin that are independent of changes in food intake and body weight. We have been investigating whether fluoxetine plays a direct role in regulating beta-cell function by quantifying its effects, at therapeutically relevant concentrations, on insulin secretion and beta-cell mass and its regulation of glucose homeostasis in vivo.