Myosin binding protein-C: a key regulator of cardiac output Cardiovascular diseases are one of the most common causes of death worldwide, with over 400 people dying each day in the UK alone. Recent discoveries have shown that cardiomyopathies (diseases of the heart muscle) are frequently involved in heart failure. We aim to understand how heart muscle function is controlled at the level of the smallest building block, the sarcomere, and how mutations in proteins important for heart function cause cardiomyopathies. A heartbeat is an orchestrated event, in which certain elements have to fulfil specific functions at a specific time. We want to understand how a protein called ‘Myosin Binding Protein-C’ (MyBP-C) helps coordinating heart muscle contraction at the molecular level.