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KCL Frost Eye Research Department

The KCL Frost Research Department at St Thomas’ Hospital, led by Professor Sheng Lim, is one of the largest ophthalmic research units in the UK in terms of patient recruitment. The Department has the only human aqueous dynamic research set-up in the UK, and is the global leader in this area of research. The department is fully equipped with all the latest research tools and is supported by a team of administrative and technical staff to ensure efficient running of trials. The Department has been involved in many large, multicentre, international randomised controlled trials, in particular, many landmarked glaucoma studies.

Members

K. Sheng Lim

K. Sheng Lim

Professor of Glaucoma Studies

COmparing the effectiveness of phacoemulsificatioN + ECP lasEr and Phacoemulsification alone for the treatment of primary open angle glaucoma in patients with cataract – a randomized controlled Trial (CONCEPT)

Prospective single blinded randomised controlled trial comparing the effectiveness of Phacoemulsification + ECP laser versus Phacoemulsification alone for the treatment of early or moderate primary open angle glaucoma in patients with comorbid visually significant cataract. Sponsor: Guy’s and St Thomas’ NHS Foundation Trust and King’s College London

The Effect of Glaucoma Surgery on Aqueous Dynamics in Patients with Glaucoma or Ocular Hypertension: An Observational Study

This is an observational study that looks at the effects of a range of surgical techniques for treating uncontrolled glaucoma and Ocular Hypertension (OHT) on aqueous dynamics. Sponsor: Guy’s and St Thomas’ NHS Foundation Trust

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients with Open-Angle Glaucoma or Ocular Hypertension

Multi-centre, randomised, masked trial to evaluate the intraocular pressure (IOP)-lowering effect and safety of Bimatoprost SR compared with selective laser trabeculoplasty (SLT) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) who are not adequately managed with topical IOP-lowering medication for reasons other than medication efficacy (e.g. due to intolerance or nonadherence). Sponsor: Allergan

Comparing surgical approaches to treat black African and African-Caribbean patients with uncontrolled primary open angle glaucoma: A randomised feasibility study (PEACE study)

Feasibility study for a proposed prospective randomised controlled trial (post-marketing comparative study) to compare the clinical and cost-effectiveness of Baerveldt tube surgery with or without Mitomycin C (MMC) with standard care (trabeculectomy with MMC) in black African/African-Caribbean patients with POAG. Sponsor: Guy’s and St Thomas’ NHS Foundation Trust + King’s College London

Treatment of Advanced Glaucoma Study (TAGS): A multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma

A multicentre RCT of current best medical care in the NHS (a stepped approach of medications) versus primary surgery. Sponsor: Nottingham University Hospitals NHS Foundation Trust

Longitudinal study of long term corneal endothelial cell density change in patients attending the glaucoma clinic.

Observational study of corneal endothelial density in patients with glaucoma or ocular hypertension and glaucoma suspects requiring ongoing monitoring. Sponsor: Guy’s and St Thomas’ NHS Foundation Trust

View all publications

Professor K. Sheng Lim - Professor of Glaucoma Studies KCL, Consultant Ophthalmic Surgeon GSTT, R&D Lead for Ophthalmology and Pain Department GSTT

Tom Sherman - Glaucoma Research Fellow

Andrew Swampillai - Glaucoma Research Fellow

Alan Duncan - Research Coordinator

Abigail Orr - Research Coordinator

Jeff Brazel - Research Performance Manager

Andrew Amon - Assistant Clinical Research Practitioner

Liz Galvis - Clinical Research Practitioner I

Isabelle Chow - Assistant Clinical Research Practitioner

Diana Kolev - Clinical Research Practitioner II

Angela Bramananthan - Research Optometrist

Sandip Patel - Research Optometrist

Irfan Versi - Research Optometrist

Shireen Ognjenovic - Research Optometrist

Emily Dowse - Research Optometrist

Our partners

BVI, Fight for sight, Eyehope, GSTT Charity, NIHR, Iridex

Fight for Sight logo

Fight for Sight
NIHR Logo

National Institute for Health Research (NIHR)

Group lead

Sheng Lim

K. Sheng Lim

Professor of Glaucoma Studies

Contact us

020 7188 4885