Krause Group

Tight regulation of cell motility and cell proliferation is essential during embryonic development for example during neural crest cell migration. Aberrant regulation of these processes can lead to cancer and metastasis.

We aim to elucidate the fundamental mechanisms controlling cell migration and proliferation. We are particularly interested in uncovering signal transduction pathways from growth factor receptors controlling the actin cytoskeleton, which drives plasma membrane protrusion at the leading edge of migrating cells. We are also exploring novel routes of endocytosis of receptors as signalling from endosomes and vesicle trafficking routes may control directed cell migration. We utilize a combination of biochemical and live cell advanced imaging approaches (FRET-FLIM, super-resolution, TIRF) to quantitatively analyse the effects of genetically altered levels of key signalling molecules thereby allowing us to discover fundamental mechanism of cytoskeletal dynamics and endocytic vesicle trafficking controlling cell proliferation, polarity and cell migration. This detailed analysis may allow us to define novel biomarkers and drug targets which could be utilised in developing targeted cancer therapies.

For more details see our dedicated page.

Members

William Barrell

Postdoctoral Research Associate

Noor Shamsinar Binti Abd Jalal

PhD Student

Matthias Krause

Senior Lecturer

Cell migration and metastasis

Role of novel endocytosis mechanisms in cell migration

In vivo neural crest migration

Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR
Moritz, S., Krause, M., Schlatter, J., Cordes, N. & Vehlow, A., 24 Oct 2021, In: Cancers. 13, 21, 5337. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3390/cancers13215337
Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
Krause, M., Stramer, B., Ameer-Beg, S., Poland, S., Levitt, J., Marcotti, S., Köchl, R., Pallett, T., Law, A-L., Binti Abd Jalal, S. & Mosis, F., 28 Sep 2021, In: Nature Communications. 12, 1, 1 p., 5687. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-25916-6
Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation
Brazzo, J. A., Biber, J. C., Nimmer, E., Heo, Y., Ying, L., Zhao, R., Lee, K., Krause, M. & Bae, Y., Jun 2021, In: Journal of Cell Science. 134, 12, jcs257709. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1242/jcs.257709
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation
Dimchev, G., Amiri, B., Humphries, A. C., Schaks, M., Dimchev, V., Stradal, T. E. B., Faix, J., Krause, M., Way, M., Falcke, M. & Rottner, K., 1 Apr 2020, In: Journal of Cell Science. 133, 7, jcs239020. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1242/jcs.239020
Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration: explants for the study of neural crest cell delamination and migration
Gonzalez Malagon, S. G., Dobson, L., Lopez Munoz, A. M., Dawson, M., Barrell, W., Marangos, P., Krause, M. & Liu, K. J., 3 Oct 2019, In: Journal of Visualized Experiments. 152, e60051. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3791/60051
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis
Chan Wah Hak, L., Khan, S., Di Meglio, I., Law, A., Lucken-ardjomande Häsler, S., Quintaneiro, L. M., Ferreira, A. P. A., Krause, M., Mcmahon, H. T. & Boucrot, E., Sep 2018, In: Nature Cell Biology. 20, 9, p. 1023-1031 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41556-018-0146-8
Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
Gonzalez Malagon, S. G., Lopez Muñoz, A. M., Doro, D., Bolger, T. G., Poon, E., Tucker, E. R., Adel Al-Lami, H., Krause, M., Phiel, C. J., Chesler, L. & Liu, K. J., 19 Mar 2018, (E-pub ahead of print) In: Nature Communications. 9, 1, 15 p., 1126. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-018-03512-5
Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
Bodo, C., Fernandes, C. & Krause, M., 1 Dec 2017, In: Scientific Reports. 7, 1, 5365. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41598-017-05043-3
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Carmona, G., Perera, U., Gillett, C., Naba, A., Law, A-L., P Sharma, V., Wang, J., Wyckoff, J., Balsamo, M., Mosis, F., De Piano, M., Monypenny, J., Woodman, N., E McConnell, R., Mouneimne, G., Van Hemelrijck, M., Cao, Y., Condeelis, J., O Hynes, R., Gertler, F. B. & 1 others, Krause, M., 29 Sep 2016, In: Oncogene. 35, p. 5155–5169 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/onc.2016.47
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Krause, M. & Gautreau, A., 1 Sep 2014, In: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 15, p. 577-590 14 p. Research output: Contribution to journal › Literature review › peer-review. DOIs: https://doi.org/10.1038/nrm3861

View all publications

GSK3 and lamellipodial dynamics in migrating neural crest cells

Funder: BBSRC - Biotechnology and Biological Sciences Research Council
Amount: £460,810
Dates: 1/06/2018 → 31/05/2021

Member of The Francis Crick Institute internal Cell Biology and Signalling Interest Group

The CRICK Cell Biology and Signalling Interest Group will bring together scientists working on diverse biological systems, with many different complementary expertise who not only want to understand how these processes are regulated in normal healthy cells, but also the numerous pathological consequences that result when they are misregulated.

Cell Biology and Signalling Interest Group

Co-organiser of The CRICK-London Cell Motility Club

More than 50 years ago, the Cell Motility Club was initiated by Michael Abercrombie, the then Professor of Zoology at University College London. His pioneering work in the 1950s developed the classic model of contact inhibition of cell locomotion and also made significant contributions to other aspects of cell migration. As a consequence, during the early 1960s the Abercrombie laboratory became a Mecca for all aspiring cell biologists and it was inevitable that a meeting group of interested “London” laboratories be established at UCL. The Cell Motility Club has continued until this day. The CRICK-London Cell Motility Club organises now a mini symposia series with two mini symposia a year in a very open and interactive format. This novel network aims to foster interactions and collaborations to promote research in cell motility, which is at the interface of developmental biology, cell biology, the cross-disciplinary mechanobiology field and require state-of-the-art computer modelling and microscopy techniques. Each mini-symposium comprises a talk of an invited speaker and 4 short talks by PhD students and Postdocs followed by a drinks reception.

The CRICK-London Cell Motility Club

The European Cytoskeletal Forum

The European Cytoskeletal Forum (ECF) has been the academic forum for cytoskeleton research in Europe for the last 34 years. The European Cytoskeletal Forum (ECF) is an international association with pure scientific goals. The specific aim of the Forum is the promotion and dissemination of scientific knowledge concerning the structure and function of cytoskeletal elements. The ECF carries out actions directly or indirectly pertaining to its objective, primarily via the organization of or participation in congresses, conferences, workshops and presentations. The ECF promotes research, collaboration, training, and education in the field of cytoskeleton research. Annual meetings of the ECF continuously provide a structured insight into the current status of the field, in an open and interdisciplinary fashion that encourages the participation of researchers from diverse fields.

European Cytoskeletal Forum

Tommy Pallett

Noor Shamsinar Binti Abd Jalal

BBSRC LIDO Rotations PhD student:

Samina Juma

Our partners

Biotechnology and Biological Sciences Research Council (UKRI)

The Engineering and Physical Sciences Research Council (EPSRC)

Contact us

matthias.krause@kcl.ac.uk

02078486959

Krause Group