Identifying the mechanisms behind antigen exposure and B cell receptor signalling in B cell leukaemia and lymphoma
Chronic lymphocytic Leukaemia (CLL) cells display constitutive B cell receptor (BCR) signalling. In this project, we aim to elucidate the mechanisms underlying BCR signalling in CLL, focussing on how, where and when it is induced using high content imaging and novel in vivo mouse models.