MOBILE MEN

Technology & ScienceHealth

MOBILE MEN

Primary Objective

To assess implementation effectiveness of LA-CAB and oral FTC-TDF (daily and coitally dependent) on retention in care, coital coverage, and PrEP choice in men who are mobile for work

Secondary objectives:

To describe adoption (acceptability, feasibility, attitudes towards and preferences) of on-demand and injectable PrEP
To understand the reach of PrEP amongst mobile men and understand the barriers to uptake
To understand patterns of use of daily, on-demand, and LA-CAB PrEP amongst different groups of mobile men and how choices/preferences change over time.
To understand implementation of LA-CAB for men amongst service providers to inform scale-up
To understand the appropriateness, feasibility and fidelity of delivering on-demand and long-acting PrEP in different settings
To describe how on-demand and long-acting PrEP are delivered in practice
To describe the service-level needs to implement on-demand and long-acting PrEP
To evaluate antibody based monitoring HIV status for LA-CAB.
To assess maintenance (affordability), cost and cost effectiveness of oral PrEP, Cab-LA and of simultaneous provision of both types of PrEP in Uganda and South Africa.

This project is funded by the European Commission, under the Global Health EDCTP3 Joint Undertaking work programme.

Methods

Open-label study of 400 men from mobile groups in South Africa and Uganda randomised to oral TDF-FTC or CAB-LA over 9 months, then access to both to 18 months. Service level process data and qualitative interviews (in depth and group discussions) with service users and service providers will run alongside the trial to evaluate preference, choice and implementation in real time. We evaluate for the first time, the implementation (including cost-effectiveness and modelling) of both LA-CAB and on demand PrEP for vulnerable men in Africa. This data gap in men for both types of PrEP will inform the WHO HIV prevention modelling and allow men in Africa access to on demand PrREP and LA-CAB.