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Technology & ScienceHealth


Primary Objective

To assess implementation effectiveness of LA-CAB and oral FTC-TDF (daily and coitally dependent) on retention in care, coital coverage, and PrEP choice in men who are mobile for work

Secondary objectives:

  1. To describe adoption (acceptability, feasibility, attitudes towards and preferences) of on-demand and injectable PrEP
  2. To understand the reach of PrEP amongst mobile men and understand the barriers to uptake
  3. To understand patterns of use of daily, on-demand, and LA-CAB PrEP amongst different groups of mobile men and how choices/preferences change over time.
  4. To understand implementation of LA-CAB for men amongst service providers to inform scale-up
  5. To understand the appropriateness, feasibility and fidelity of delivering on-demand and long-acting PrEP in different settings
  6. To describe how on-demand and long-acting PrEP are delivered in practice
  7. To describe the service-level needs to implement on-demand and long-acting PrEP
  8. To evaluate antibody based monitoring HIV status for LA-CAB.
  9. To assess maintenance (affordability), cost and cost effectiveness of oral PrEP, Cab-LA and of simultaneous provision of both types of PrEP in Uganda and South Africa.

This project is funded by the European Commission, under the Global Health EDCTP3 Joint Undertaking work programme.

MOBILE MEN project graph


Open-label study of 400 men from mobile groups in South Africa and Uganda randomised to oral TDF-FTC or CAB-LA over 9 months, then access to both to 18 months. Service level process data and qualitative interviews (in depth and group discussions) with service users and service providers will run alongside the trial to evaluate preference, choice and implementation in real time. We evaluate for the first time, the implementation (including cost-effectiveness and modelling) of both LA-CAB and on demand PrEP for vulnerable men in Africa. This data gap in men for both types of PrEP will inform the WHO HIV prevention modelling and allow men in Africa access to on demand PrREP and LA-CAB.

    Our Partners

     London School of Hygiene & Tropical Medicine

    London School of Hygiene & Tropical Medicine

    Desmond Tutu HIV Foundation

    Desmond Tutu Health Foundation

    UKRI Log

    MRC/UVRI and LSHTM Uganda Research Unit

    Assistance Publique - Hopitaux de Paris

    Assistance Publique – Hôpitaux de Paris

    University College London

    University College London

    HE2RO logo



    Africa Health Research Institute

    European Union logo accompanied by text 'Funded by the European Union'

    European Commission

    Project status: Starting
    Mobile Men

    Principal Investigator


    Funding Body: European Commission

    Amount: € 4,665,192.50

    Period: July 2023 - July 2026