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Persistent Physical Symptoms Research and Treatment Unit

The Persistent Physical Symptoms Research and Treatment Unit is a national specialist service undertaking assessment, treatment and research regarding chronic fatigue syndrome (CFS, sometimes known as ‘ME’). 

The unit is a partnership between King's College London, South London and Maudsley NHS Trust and NIHR Biomedical Research Centre

Our routine treatment is cognitive behaviour therapy (CBT), which has been shown in several randomised controlled trials to be an effective intervention for CFS/ME. We also provide Graded Exercise Therapy (GET) and are also now seeing patients with fatigue in relation to chronic diseases. 

Adults with CFS/ME who fulfil specific research criteria may be offered the opportunity to participate in research at this unit, and adolescents with CFS/ME may be eligible to take part in our research. 


BRC BioResource for mental and neurological health: a national project to build up a central library of information or 'biobank' of biological samples in order to better understand different psychiatric and neurological illnesses as well as to help researchers to develop new and better treatments more quickly. 

A study investigating attention and concentration issues in chronic fatigue syndrome 

A study investigating the role of the immune system in the development of persistent fatigue 

A study investigating the cortisol levels in bipolar, atypical and non-atypical depression and chronic fatigue syndrome. 

A study of factors influencing nervous system activity in chronic fatigue syndrome 

Contact us

Mapother House, 1st Floor 

De Crespigny Park 

Denmark Hill 

London SE5 8AZ 

0203 228 5075