Structure and function of cardiac myosin binding protein C (cMyBP-C)
In collaboration with the Gautel & Kampourakis groups we are investigating the conformation, dynamics and interactins of several portions of the enigmatic cMyBP-C. This protein interacts with several parts of the myosin heavy and light chains. Some of these interactions are regulated by phosphorylation and we are investigating the conformational changes in the protein induced by phosphorylation.