Postdoctoral Research Associate
Academic Clinical Lecturer and Periodontology Registrar
Head of the Centre for Craniofacial & Regenerative Biology
Postdoctoral Research Associate
Molecular dissection of dental pulp stem cell microenvironments
Cell transitions that lead to differentiation of specific tooth cell types during growth and repair are being investigated at the single cell level. The aim is to understand how stem cell behaviour is controlled.
Development of biological approaches for human tooth regeneration and repair
Discovery research directed towards understanding dental stem cells is being used as the basis to develop novel biologically-based approaches to treat dental caries and periodontal disease by stimulating resident stem cells.
ReDent 1 is a product we have developed to treat deep caries lesions by activating dental pulp stem cells to make regenerative dentine an produce a natural repair. Clinical trials of ReDent 1 are planned for 2020.
ReDent 2 is bioactivate glass that stimulates odontoblast activity during tooth repair.
Similar products are being developed to treat periodontal disease.
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Zhao, J., Faure, L., Adameyko, I. & Sharpe, P. T., 2020, (Accepted/In press) In : Stem Cells. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/stem.3288
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Hamline, M. Y., Corcoran, C. M., Wamstad, J. A., Miletich, I., Feng, J., Lohr, J. L., Hemberger, M., Sharpe, P. T., Gearhart, M. D. & Bardwell, V. J., 1 Jan 2020, (Accepted/In press) In : Developmental Biology. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.ydbio.2020.06.013
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Krivanek, J., Soldatov, R. A., Kastriti, M. E., Chontorotzea, T., Herdina, A. N., Petersen, J., Szarowska, B., Landova, M., Matejova, V. K., Holla, L. I., Kuchler, U., Zdrilic, I. V., Vijaykumar, A., Balic, A., Marangoni, P., Klein, O. D., Neves, V. C. M., Yianni, V., Sharpe, P. T., Harkany, T. & 6 others, Metscher, B. D., Bajénoff, M., Mina, M., Fried, K., Kharchenko, P. V. & Adameyko, I., 23 Sep 2020, In : Nature Communications. 11, 1, 4816. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41467-020-18512-7
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Yianni, V. & Sharpe, P. T., 25 Aug 2020, In : Frontiers in Dental Medicine. 1 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fdmed.2020.00006
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Ahmadi Birjandi, A., Suzano, F. & Sharpe, P., 29 Aug 2020, (Accepted/In press) In : International Journal of Molecular Sciences. Research output: Contribution to journal - Article
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Yamada, A., Kawasaki, M., Miake, Y., Yamada, Y., Blackburn, J., Kawasaki, K., Trakanant, S., Nagai, T., Nihara, J., Kudo, T., Meguro, F., Schmidt-Ullrich, R., Liu, B., Hu, Y., Page, A., Ramírez, Ã., Sharpe, P. T., Maeda, T., Takagi, R. & Ohazama, A., 1 Oct 2020, In : Oral Diseases. 26, 7, p. 1513-1522 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/odi.13384
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Daltoe, F. P., de Oliveira, N. A. J., Peron, C. N., Sharpe, P. T. & Mantesso, A., 1 Jan 2020, In : Brazilian oral research. 34, e033. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1590/1807-3107BOR-2020.VOL34.0033
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Yianni, V. & Sharpe, P. T., May 2020, In : Bone. 134, 115309. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.bone.2020.115309
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Zaugg, L. K., Banu, A., Walther, A. R., Chandrasekaran, D., Babb, R. C., Salzlechner, C., Hedegaard, M. A. B., Gentleman, E. & Sharpe, P. T., 1 Jan 2020, (Accepted/In press) In : Journal of Dental Research. 99, 5, p. 544-551 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1177/0022034520908593
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Babb, R. C., Chandrasekaran, D., Zaugg, L. K. & Sharpe, P. T., 1 Jan 2019, Methods in Molecular Biology. Humana Press Inc, p. 111-119 9 p. (Methods in Molecular Biology; vol. 1922). Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-1-4939-9012-2_11
The Sharpe Group were awarded the 2017 King's Award for Research Project of the Year.
The research project described a new method of stimulating the natural process of renewal of dental tissues and was developed by research group members including PhD students Vitor Neves and Rebecca Babb, and lab technician Dhivya Chandrasekaran, led by Centre Director, Professor Paul Sharpe.
The winning project demonstrated a way to stimulate the stem cells contained in the pulp of teeth to generate new dentine – a significant mineralised component of the tooth - in large cavities. This proof of principle research potentially paves the way for alternative clinical procedures to restore damaged teeth and thereby reduce the need for fillings. This novel, biological approach to repair might be expected to be an improvement of current procedures which can be prone to infections and frequently require replacement.