Dental Tissue Regeneration and Repair
People
Postdoctoral Research Associate
PhD Student
Emeritus Professor of Craniofacial Biology
Postdoctoral Research Associate
Projects
Molecular dissection of dental pulp stem cell microenvironments
Cell transitions that lead to differentiation of specific tooth cell types during growth and repair are being investigated at the single cell level. The aim is to understand how stem cell behaviour is controlled.
Development of biological approaches for human tooth regeneration and repair
Discovery research directed towards understanding dental stem cells is being used as the basis to develop novel biologically-based approaches to treat dental caries and periodontal disease by stimulating resident stem cells. ReDent 1 is a product we have developed to treat deep caries lesions by activating dental pulp stem cells to make regenerative dentine an produce a natural repair. Clinical trials of ReDent 1 are planned for 2020. ReDent 2 is bioactivate glass that stimulates odontoblast activity during tooth repair. Similar products are being developed to treat periodontal disease.
Publications
Awards
The Sharpe Group were awarded the 2017 King's Award for Research Project of the Year.
The research project described a new method of stimulating the natural process of renewal of dental tissues and was developed by research group members including PhD students Vitor Neves and Rebecca Babb, and lab technician Dhivya Chandrasekaran, led by Centre Director, Professor Paul Sharpe.
The winning project demonstrated a way to stimulate the stem cells contained in the pulp of teeth to generate new dentine – a significant mineralised component of the tooth - in large cavities. This proof of principle research potentially paves the way for alternative clinical procedures to restore damaged teeth and thereby reduce the need for fillings. This novel, biological approach to repair might be expected to be an improvement of current procedures which can be prone to infections and frequently require replacement.
Activities
13th Tooth Morphogenesis and Differentiation Conference
1st September – 6th September 2019 Worcester College Oxford University Oxford
News
New research identifies potential treatment to manage effects of periodontitis
A study from King's researchers has identified use of a cell type known as a telocyte as a route for therapeutic interventions to limit inflammation and bone...
People
Postdoctoral Research Associate
PhD Student
Emeritus Professor of Craniofacial Biology
Postdoctoral Research Associate
Projects
Molecular dissection of dental pulp stem cell microenvironments
Cell transitions that lead to differentiation of specific tooth cell types during growth and repair are being investigated at the single cell level. The aim is to understand how stem cell behaviour is controlled.
Development of biological approaches for human tooth regeneration and repair
Discovery research directed towards understanding dental stem cells is being used as the basis to develop novel biologically-based approaches to treat dental caries and periodontal disease by stimulating resident stem cells. ReDent 1 is a product we have developed to treat deep caries lesions by activating dental pulp stem cells to make regenerative dentine an produce a natural repair. Clinical trials of ReDent 1 are planned for 2020. ReDent 2 is bioactivate glass that stimulates odontoblast activity during tooth repair. Similar products are being developed to treat periodontal disease.
Publications
Awards
The Sharpe Group were awarded the 2017 King's Award for Research Project of the Year.
The research project described a new method of stimulating the natural process of renewal of dental tissues and was developed by research group members including PhD students Vitor Neves and Rebecca Babb, and lab technician Dhivya Chandrasekaran, led by Centre Director, Professor Paul Sharpe.
The winning project demonstrated a way to stimulate the stem cells contained in the pulp of teeth to generate new dentine – a significant mineralised component of the tooth - in large cavities. This proof of principle research potentially paves the way for alternative clinical procedures to restore damaged teeth and thereby reduce the need for fillings. This novel, biological approach to repair might be expected to be an improvement of current procedures which can be prone to infections and frequently require replacement.
Activities
13th Tooth Morphogenesis and Differentiation Conference
1st September – 6th September 2019 Worcester College Oxford University Oxford
News
New research identifies potential treatment to manage effects of periodontitis
A study from King's researchers has identified use of a cell type known as a telocyte as a route for therapeutic interventions to limit inflammation and bone...
Our Partners
Georgia Tech
Group lead
Emeritus Professor of Craniofacial Biology
Contact us
Professor Paul Sharpe
Centre for Craniofacial & Regenerative Biology
Floor 27, Guy's Tower Wing
Guy's Hospital