Postdoctoral Research Associate
Academic Clinical Lecturer and Periodontology Registrar
Dickinson Professor of Craniofacial Biology
Postdoctoral Research Associate
Molecular dissection of dental pulp stem cell microenvironments
Cell transitions that lead to differentiation of specific tooth cell types during growth and repair are being investigated at the single cell level. The aim is to understand how stem cell behaviour is controlled.
Development of biological approaches for human tooth regeneration and repair
Discovery research directed towards understanding dental stem cells is being used as the basis to develop novel biologically-based approaches to treat dental caries and periodontal disease by stimulating resident stem cells.
ReDent 1 is a product we have developed to treat deep caries lesions by activating dental pulp stem cells to make regenerative dentine an produce a natural repair. Clinical trials of ReDent 1 are planned for 2020.
ReDent 2 is bioactivate glass that stimulates odontoblast activity during tooth repair.
Similar products are being developed to treat periodontal disease.
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Sordi, M. B., Fredel, M. C., da Cruz, A. C. C., Sharpe, P. T. & de Souza Magini, R., 2022, (Accepted/In press) In: CLINICAL ORAL INVESTIGATIONS. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1007/s00784-022-04696-3
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Kudo, T., Kawasaki, M., Kawasaki, K., Meguro, F., Nihara, J., Honda, I., Kitamura, M., Fujita, A., Osawa, K., Ichikawa, K., Nagai, T., Ishida, Y., Sharpe, P. T., Maeda, T., Saito, I. & Ohazama, A., 2022, (Accepted/In press) In: Oral Diseases. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/odi.14162
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Yianni, V. & Sharpe, P. T., 2022, Methods in Molecular Biology. Humana Press Inc, p. 81-89 9 p. (Methods in Molecular Biology; vol. 2403). Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review. DOIs: https://doi.org/10.1007/978-1-0716-1847-9_7
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Ozgencil, M., Barwell, J., Tischkowitz, M., Izatt, L., Kesterton, I., Simpson, M., Sharpe, P., de Sepulveda, P. & Solomon, E. V. E., Dec 2021, In: PLoS ONE. 16, 12, e0260852. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0260852
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Zhao, J., Volponi, A. A., Caetano, A. & Sharpe, P. T., 26 Jun 2020, Encyclopedia of Bone Biology. Elsevier, p. 109-118 10 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Zhao, J. & Sharpe, P., 20 Aug 2021, In: Bio-protocol. 11, 16, e4120. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.21769/BioProtoc.4120
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Contessi Negrini, N., Angelova Volponi, A., Sharpe, P. T. & Celiz, A. D., 13 Sep 2021, In: ACS Biomaterials Science and Engineering. 7, 9, p. 4330-4346 17 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acsbiomaterials.1c00136
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Alaohali, A., Brauer, D. S., Gentleman, E. & Sharpe, P. T., Aug 2021, In: Dental Materials. 37, 8, p. 1307-1315 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.dental.2021.05.003
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Alaohali, A., Salzlechner, C., Zaugg, L. K., Suzano, F., Martinez, A., Gentleman, E. & Sharpe, P. T., Jan 2022, In: Journal of Dental Research. 101, 1, p. 46-53 8 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1177/00220345211020652
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Birjandi, A. A., Neves, V. C. M. & Sharpe, P., Apr 2021, In: Regenerative medicine. 16, 4, p. 343-345 3 p. Research output: Contribution to journal › Editorial › peer-review. DOIs: https://doi.org/10.2217/rme-2021-0003
The Sharpe Group were awarded the 2017 King's Award for Research Project of the Year.
The research project described a new method of stimulating the natural process of renewal of dental tissues and was developed by research group members including PhD students Vitor Neves and Rebecca Babb, and lab technician Dhivya Chandrasekaran, led by Centre Director, Professor Paul Sharpe.
The winning project demonstrated a way to stimulate the stem cells contained in the pulp of teeth to generate new dentine – a significant mineralised component of the tooth - in large cavities. This proof of principle research potentially paves the way for alternative clinical procedures to restore damaged teeth and thereby reduce the need for fillings. This novel, biological approach to repair might be expected to be an improvement of current procedures which can be prone to infections and frequently require replacement.