Middle ear development Since 2003 the Tucker Laboratory has been researching how the middle ear forms during normal development and what goes wrong in cases of conductive hearing loss. This work is currently funded by The Medical Research Council (MRC) & Wellcome Trust (Senior Investigator Award). In addition, the laboratory has been investigating the evolution of the unique mammalian middle ear using a comparison of placental, marsupial and monotreme mammals. Most recently, we have been studying problems associated with cavitation of the middle ear and the genetics behind middle ear inflammation (Otitis Media). The Tucker Laboratory has been investigating mice that have a genetic disposition to OM, to stimulate novel treatments and preventative methods. In addition we have been investigating how structures in the middle ear repair after injury. Our interest in the middle ear has led to collaborations with the ear surgeons and radiologists at St Thomas’ Hospital to understand the key clinically driven questions, funded by a grant from Action on Hearing Loss.