Droplet Interface Bilayers
Using microfabrication and 3D-printing we develop new artificial lipid bilayers that give us control over membrane properties.
An Artificial Plasma Membrane
We build mimics of cell membranes from their component parts. This helps us understand precisely how these components work together. It also lets us build artificial protocells with new emergent properties.
Nanopore Sensing
We develop new optical methods that exploit the flow of ions through protein nanopores for sensing and sequencing.
Label-free Optical Imaging
We apply a new generation of label-free single-molecule methods to go beyond the current sensitivity and speed limits of single-molecule methods.
Linking Conformation to Function in Individual Ion Channels
By combining single-molecule sensitive measurements of shape change and ionic flux in an ion channel we are able to shed new light onto the mechanism of these important proteins.
Assembly of Membrane Protein Complexes
We are interested in precisely how large macromolecular protein complexes can assemble in a membrane. What drives this assembly, and how can we control it?