The Wanford group studies the molecular pathogenesis of diseases caused by the major antimicrobial-resistant bacterial pathogens Klebsiella pneumoniae and Escherichia coli.

Using in vitro and in vivo infection models and integrating approaches from molecular microbiology, genomics, and immunology, we work to understand how these pathogens regulate expression of virulence factors during transition between host compartments, and the functions of these factors during host-pathogen interactions. By defining the complex interplay between pathogen genetics and host response, we aim to improve pathogen genomic surveillance and identify targets for novel therapeutics against infection.

A current focus of the lab is understanding regulation of capsular polysaccharide (capsule) expression in the WHO priority pathogen Klebsiella pneumoniae. We have recently identified that stretches of repetitive DNA in genes encoding regulators of capsule expression drive a high-frequency, reversible switch in gene expression termed 'phase variation'. We are now working to understand the factors dictating the frequency of phase variation in the host, the impact of capsule switching on interaction with host cells, and its role in the spread of antimicrobial resistance.

We are always keen to hear from prospective group members, and are happy to discuss and support applications for external postdoctoral fellowships (e.g. Wellcome Early Career Awards, Marie Skłodowska-Curie Fellowships).