The Zampetaki Lab investigates the molecular and cellular basis of vascular remodelling. An active area of research is focused on understanding the role of metabolic rewiring in vascular dysfunction. We employ a human blood vessel organoid model, a system that can faithfully recapitulate the human microvasculature and responds rapidly to metabolic changes. The prompt structural remodelling that is observed, makes this model extremely attractive for mechanistic studies and the identification of potential targets for novel therapeutic approaches. Importantly, this short timeframe of response is also useful and desirable for high throughput drug and small compound screening applications. Furthermore, the use of patient derived induced pluripotent stem cells and human blood vessel organoids that can capture the interpatient variation and predict drug responses more accurately may facilitate the development of precision medicine strategies.