The Digital Liver Group is a pioneering research team at King’s College Hospital dedicated to advancing the field of translational systems medicine with a specialised focus on liver diseases. Our group leverages state‐of‐the‐art computational tools—ranging from genome-scale metabolic modelling to deep learning techniques—to construct digital representations of liver cells and tissues. These “digital liver” models enable us to simulate intricate hepatic functions, predict disease progression, and evaluate therapeutic responses with unprecedented precision.

Our Research Vision

At the core of our mission is the belief that a detailed, systems-level understanding of liver biology can unlock transformative insights into complex hepatic disorders. By integrating multi-omics data with robust systems biology approaches, we aim to:

• Map the Digital Liver: Develop comprehensive digital models that capture the dynamic behaviour of liver cells and their microenvironment.
• Innovate Therapeutics: Identify novel drug targets and reposition existing therapies through in-depth simulations and predictive analyses.
• Personalise Treatment: Tailor therapeutic strategies by simulating patient-specific liver functions, thereby enhancing treatment outcomes.
• Bridge Bench and Bedside: Foster strong translational links between computational discoveries and clinical applications, ensuring our research yields tangible benefits for patient care.