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Computational models of ribosome movement reveal a translation elongation controlled RNA regulon in yeast

Speaker: Dr Tobias von der Haar, School of Biosciences, University of Kent

Host: Professor Sasi Conte

Abstract:

The regulation of protein levels at the protein synthesis stage, or translational control, occurs frequently in cells and is essential for adapting the proteome regulation during development and adaptation to stresses. Historically, translational control has been thought to be exerted exclusively at the level of translation initiation. Recent findings challenge this view, and contributions to translational control that arise from the elongation stage have now been clearly documented.

A salient parameter by which translation elongation can modulate proteins synthesis rates is via the speed with which the ribosome decodes the mRNA. I will present work from my lab which interprets ribosome movement on different sequences through cycles of computational modelling, experimentation, and genomic data analyses. Our most recent results suggest that translation elongation limits protein synthesis rates on a sizeable minority of transcripts in baker’s yeast and that initiation and elongation controlled transcripts form two pools that can be separately addressed for regulation.

Event details

Classroom G8, New Hunt’s House
Guy’s Campus
Great Maze Pond, London SE1 1UL