Professor Sasi Conte Academics Professor of Structural Biology School Academic Lead (International). Director of the Centre for Biomolecular Spectroscopy. Contact details sasi.conte@kcl.ac.uk +44 (0) 20 7848 6194
Maternal Larp6 controls oocyte development, chorion formation and elevation Hau, H. T. A., Ogundele, O., Hibbert, A. H., Monfries, C. A. L., Exelby, K., Wood, N. J., Nevarez-Mejia, J., Carbajal, M. A., Fleck, R. A., Dermit, M., Mardakheh, F. K., Williams-Ward, V. C., Pipalia, T. G., Conte, M. R. & Hughes, S. M., 13 Feb 2020, In : Development (Cambridge, England). 147, 4, dev187385. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1242/dev.187385https://doi.org/10.1242/dev.187385 Structural dynamics in the La-module of La-related proteins Conte, M., Feb 2020, (Accepted/In press) In : Rna Biology. Research output: Contribution to journal - Article Isothermal Titration Calorimetry Enables Rapid Characterization of Enzyme Kinetics and Inhibition for the Human Soluble Epoxide Hydrolase Abis, G., Pacheco-Gómez, R., Bui, T. T. T. & Conte, M. R., 3 Dec 2019, In : Analytical Chemistry. 91, 23, p. 14865-14872 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1021/acs.analchem.9b01847 The La-related proteins: Structures and interactions of a versatile superfamily of RNA binding proteins Conte, M. R., 3 Dec 2019, In : Rna Biology. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1080/15476286.2019.1695712 PDXK mutations cause polyneuropathy responsive to pyridoxal 5′-phosphate supplementation Chelban, V., Wilson, M. P., Warman Chardon, J., Vandrovcova, J., Zanetti, M. N., Zamba-papanicolaou, E., Efthymiou, S., Pope, S., Conte, M. R., Abis, G., Liu, Y., Tribollet, E., Haridy, N. A., Botía, J. A., Ryten, M., Nicolaou, P., Minaidou, A., Christodoulou, K., Kernohan, K. D., Eaton, A. & 18 others, Osmond, M., Ito, Y., Bourque, P., Jepson, J. E. C., Bello, O., Bremner, F., Cordivari, C., Reilly, M. M., Foiani, M., Heslegrave, A., Zetterberg, H., Heales, S. J. R., Wood, N. W., Rothman, J. E., Boycott, K. M., Mills, P. B., Clayton, P. T. & Houlden, H., 1 Aug 2019, In : Annals of Neurology. 86, 2, p. 225-240 16 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/ana.25524 LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA Cruz-Gallardo, I., Martino, L., Kelly, G., Atkinson, R. A., Trotta, R., De Tito, S., Coleman, P., Ahdash, Z., Gu, Y., Bui, T. T. T. & Conte, M. R., 7 May 2019, In : Nucleic Acids Research. 47, 8, p. 4272-4291 20 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1093/nar/gkz144 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism Abis, G., Charles, R. L., Kopec, J., Yue, W. W., Atkinson, R. A., Bui, T. T. T., Lynham, S., Popova, S., Sun, Y-B., Fraternali, F., Eaton, P. & Conte, M. R., May 2019, In : Communications Biology. 2, 1, 188. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s42003-019-0426-2 Resonance assignment of human LARP4A La module Cruz-Gallardo, I., Martino, L., Trotta, R., De Tito, S., Kelly, G., Atkinson, R. A., Randazzo, A. & Conte, M. R., 1 Apr 2019, In : Biomolecular NMR Assignments. 13, 1, p. 169-172 4 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1007/s12104-019-09871-4https://doi.org/10.1007/s12104-019-09871-4 Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH), and of its functional C-terminal domain Abis, G., Charles, R. L., Eaton, P. & Conte, M. R., Jan 2019, In : Protein expression and purification. 153, p. 105-113 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.pep.2018.09.001 TAB1-induced autoactivation of p38α mitogen-activated protein kinase is crucially dependent on threonine 185 Thapa, D., Nichols, C., Bassi, R., Martin, E. D., Verma, S., Conte, M. R., De Santis, V., De Nicola, G. F. & Marber, M. S., 1 Mar 2018, In : Molecular and Cellular Biology. 38, 5, e00449-17. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1128/MCB.00409-17 View all publications