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RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. It is also an essential structural and enzymatic component of many cellular machines and phase-separated compartments. Dysregulated RNA metabolism leads to many diseases including metabolic and neurodegenerative disorders as well as cancer. RNA viruses, such as SARS-CoV-2, HIV-1, and influenza virus, cause a large disease burden worldwide. RNA-based therapeutics and biosensors have a wide range of clinical applications. Understanding of the mechanisms of RNA biology will promote fundamental discoveries to allow the development of new therapies and diagnostic technologies.

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